In this paper, we are devoted to establishing the point-wise decay estimates for solution to the 5D defocusing energy-critical Hartree equation with an initial data in
H
2
(
R
5
)
∩
L
1
(
R
5
)
${H}^{2}\left({\mathbb{R}}^{5}\right)\cap {L}^{1}\left({\mathbb{R}}^{5}\right)$
. We show that the nonlinear solution has the same time decay rate as the linear one. The main new ingredient is that we used the theories of Lorentz spaces to overcome the low power of nonlinearity.