Poisoning by the External Application of Belladonna

Morgan, Wendy

doi:10.1136/bmj.2.309.621

Cited by 3 publications

(2 citation statements)

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“…Our understanding of skin permeation has evolved from early observations of adverse systemic effects following skin exposure, such as systemic poisoning after belladonna plaster applications [5] and headaches after occupational exposure to nitroglycerin in explosives factories [6]. The observation that skin was relatively permeable to lipid-soluble substances but not to water and electrolytes [7] was explored in systematic in vitro studies conducted by Rein in the 1920s [8].…”

Section: Skin Delivery Pastmentioning

confidence: 99%

Topical and Transdermal Drug Delivery: From Simple Potions to Smart Technologies

Benson

Grice

Mohammed

et al. 2019

CDD

230

124

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This overview on skin delivery considers the evolution of the principles of percutaneous absorption and skin products from ancient times to today. Over the ages, it has been recognised that products may be applied to the skin for either local or systemic effects. As our understanding of the anatomy and physiology of the skin has improved, this has facilitated the development of technologies to effectively and quantitatively deliver solutes across this barrier to specific target sites in the skin and beyond. We focus on these technologies and their role in skin delivery today and in the future.

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Section: Skin Delivery Pastmentioning

confidence: 99%

Topical and Transdermal Drug Delivery: From Simple Potions to Smart Technologies

Benson

Grice

Mohammed

et al. 2019

CDD

230

124

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“…Nevertheless, in 1877, one review still suggested that intact human skin was totally impermeable to all substances (Fleischer, ) – even though several cases of systemic poisoning after external application of belladonna (e.g. plaster, liniment and lotion) were reported in the British Medical Journal in the 1860–1870s (Morgan, ; Harrison, ).…”

Section: Historymentioning

confidence: 99%

Transdermal patches: history, development and pharmacology

Pastore

Kalia

Horstmann³

et al. 2015

British J Pharmacology

434

279

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Transdermal patches are now widely used as cosmetic, topical and transdermal delivery systems. These patches represent a key outcome from the growth in skin science, technology and expertise developed through trial and error, clinical observation and evidence-based studies that date back to the first existing human records. This review begins with the earliest topical therapies and traces topical delivery to the present-day transdermal patches, describing along the way the initial trials, devices and drug delivery systems that underpin current transdermal patches and their actives. This is followed by consideration of the evolution in the various patch designs and their limitations as well as requirements for actives to be used for transdermal delivery. The properties of and issues associated with the use of currently marketed products, such as variability, safety and regulatory aspects, are then described. The review concludes by examining future prospects for transdermal patches and drug delivery systems, such as the combination of active delivery systems with patches, minimally invasive microneedle patches and cutaneous solutions, including metered-dose systems.

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Selection of Topically Applied Chemical Candidates: Transdermal Drug Delivery Systems

Pastore

Roberts

2017

Skin Permeation and Disposition of Therapeutic and Cosmeceutical Compounds

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Poisoning by the External Application of Belladonna

Cited by 3 publications

References 0 publications

Topical and Transdermal Drug Delivery: From Simple Potions to Smart Technologies

Topical and Transdermal Drug Delivery: From Simple Potions to Smart Technologies

Transdermal patches: history, development and pharmacology

Selection of Topically Applied Chemical Candidates: Transdermal Drug Delivery Systems

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