Polar lipids from the marine macroalga Palmaria palmata inhibit lipopolysaccharide-induced nitric oxide production in RAW264.7 macrophage cells

The effect of consuming Palmaria palmata-enriched bread on inflammatory markers, antioxidant status, lipid profile and thyroid function in a randomised placebo-controlled intervention trial in healthy adults

“…To our knowledge, this is the first study to investigate the effect of consuming P. palmata on markers of inflammatory, oxidative and lipid status in humans. The observed immunostimulatory activity noted in this study is in contrast to previous studies that have shown red algae species to exert anti-inflammatory activity [13][14][15][16]. Research to date has implicated the high EPA content of the P. palmata to exert this anti-inflammatory effect [16,33].…”

“…The observed immunostimulatory activity noted in this study is in contrast to previous studies that have shown red algae species to exert anti-inflammatory activity [13][14][15][16]. Research to date has implicated the high EPA content of the P. palmata to exert this anti-inflammatory effect [16,33]. It is plausible that the high temperature of the baking process may result in thermally induced transformation and inactivation of the beneficial n-3 PUFAs [34,35].…”

“…Several in vivo animal studies have reported a range of red seaweed species to have anti-inflammatory activity [13][14][15][16]. Specifically for P. palmata, this anti-inflammatory activity has been attributed to its relatively high proportion of eicosapentaenoic acid (EPA) concentration and its favourably low ω6/ω3 ratio (0.13) [17].…”

Seaweeds as Source of New Bioactive Prototypes

“…The bioactive compounds 25 and 26 were demonstrated nitricoxide inhibitory activity in macrophage RAW264.7 cells Algae -Organisms for Imminent Biotechnologywith IC 50 values of 36.5 and 11.0 µM. Moreover, the compound 26 also has been shown to inhibit the production of nitric oxide synthase in a dose-dependent manner [62]. Other activities, such as antiviral (HSV-1 and HSV-2) and anticancer, have also been described for glycolipids [63,64].…”

Effect of Three-spot Seahorse Petroleum Ether Extract on Lipopolysaccharide Induced Macrophage RAW264.7 Inflammatory Cytokine Nitric Oxide and Composition Analysis

“…Valerie Boutar et al 35 found that fish oil supplementation and essential fatty acid deficiency reduce NO synthesis by rat macrophages. Fatty acid-derived modifications in membrane sequence and in the availability of substrates for eicosanoid synthesis are enduring mechanisms that are deemed important in explicating the effects observed 36 , and the differential effects of fractions upon iNOS indicates that iNOS may be regulated by unsaturated fatty acids or compounds derived from them 37 .…”