Polarimetric Measurements of Surface Chirality Based on Linear and Nonlinear Light Scattering

Gogoi, Ankur; Konwer, Surajit; Zhuo, Guan‐Yu

doi:10.3389/fchem.2020.611833

Cited by 11 publications

(7 citation statements)

References 264 publications

(209 reference statements)

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“…Because chiral structures exhibit a polarization-dependent interaction with light, optical analytical techniques are well suited to sense and characterize chirality. ,− Chiral objects are optically active, meaning that their enantiomers respond differently to polarized light. The first type of optical activity is dichroism, in which a chiral object’s absorption of light is polarization-dependent .…”

Section: Overview Of Chirality Sensingmentioning

confidence: 99%

Nanophotonic Approaches for Chirality Sensing

Warning¹,

Miandashti²,

McCarthy³

et al. 2021

ACS Nano

177

154

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Chiral nanophotonic materials are promising candidates for biosensing applications because they focus light into nanometer dimensions, increasing their sensitivity to the molecular signatures of their surroundings. Recent advances in nanomaterial-enhanced chirality sensing provide detection limits as low as attomolar concentrations (10–18 M) for biomolecules and are relevant to the pharmaceutical industry, forensic drug testing, and medical applications that require high sensitivity. Here, we review the development of chiral nanomaterials and their application for detecting biomolecules, supramolecular structures, and other environmental stimuli. We discuss superchiral near-field generation in both dielectric and plasmonic metamaterials that are composed of chiral or achiral nanostructure arrays. These materials are also applicable for enhancing chiroptical signals from biomolecules. We review the plasmon-coupled circular dichroism mechanism observed for plasmonic nanoparticles and discuss how hotspot-enhanced plasmon-coupled circular dichroism applies to biosensing. We then review single-particle spectroscopic methods for achieving the ultimate goal of single-molecule chirality sensing. Finally, we discuss future outlooks of nanophotonic chiral systems.

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Section: Overview Of Chirality Sensingmentioning

confidence: 99%

Nanophotonic Approaches for Chirality Sensing

Warning¹,

Miandashti²,

McCarthy³

et al. 2021

ACS Nano

177

154

View full text Add to dashboard Cite

show abstract

“…To examine the chirality of molecules, the devices polarimeters and circular dichroism spectrometers are useful and sensitive (Gogoi et al, 2021). Homochirality (100% enantiomeric excess) is a strong indicator of a chemical system assembled in a delicate and organizational manner (Blackmond, 2010).…”

Section: Polarimetry and Circular Dichroism Spectroscopymentioning

confidence: 99%

Detection of biosignatures in terrestrial Mars analogs: Strategical and technical assessments

Shen¹,

Chen²,

Sun³

et al. 2022

Earth and Planetary Physics

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The search for potential signs of Martian life has been planned and implemented by worldwide countries for decades. Due to the high expenditure on Mars exploration, more easily accessible Marslike regions on Earth are invaluable targets for astrobiology research to understand the detection of potential Martian biosignatures. In order to detect potential life signals beyond Earth, questions on how to define life and biosignatures need to be carefully inspected. This review summarizes scientific instrumental techniques, our "eyes" and "hands", that facilitate identifying and quantifying biosignatures on Mars. Scientific devices that can be applied in astrobiology include electromagnetic spectrum-based spectrometers, mass spectrometers, redox potential indicators, circular dichroism polarimeters, in situ nucleic acid sequencers, life isolation/cultivation systems, and imagers. These techniques should be first tested in Mars analog extreme environments on Earth to validate their practicality on Mars. To better understand the instrumental detectability of biosignatures on Mars through its evolutionary history, terrestrial Mars analogs are divided into four major categories according to their similarities to different geological ages of Mars (the Early-Middle Noachian Period, the Late Noachian-Early Hesperian Period, the Late Hesperian-Early Amazonian Period, and the Middle-Late Amazonian Period). Future missions are suggested to explore more on the early terrains in Mars' Southern Hemisphere once the landing issue is solved engineeringly, since these explorations permit investigating a continuum of the habitability shift through Mars geological history. Moreover, practical applications of scientific instruments listed above are briefly reviewed based on the four categories of Mars analogs, and instruments applied for autonomous robotic rover tests in Mars analogs are further discussed. For engineering efficiency, a Mars rover ought to be equipped with as few assemblable instruments as possible. Therefore, once candidate landing regions 1 Biosignatures in Mars analogson Mars are defined, the portable suites of instruments should be smartly devised on the basis of the geological, geochemical, geomorphological, and chronological characteristics of the landing regions. Laboratory-based experiments without engineering restrictions are further encouraging and appealing if Mars sample-return missions are successfully completed. To exclude false positive and false negative conclusions in life discovery, the combined use and replication studies of multiple analytical techniques must be performed to confirm the observational results.

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“…[ [99][100][101][102][103]. Therefore, protein-protein, protein-lipid and lipid-lipid interactions are important not only to understand the science behind the physiology of cells, but also for the validation and discovery of newer drugs.…”

Section: Analysis Of Lipid/protein Moleculesmentioning

confidence: 99%

Surface Plasmon Resonance Biosensors Based on Kretschmann Configuration: Basic Instrumentation and Applications

Shukla

Chetri²,

Boruah

et al. 2022

Lecture Notes in Nanoscale Science and Technology

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Surface Plasmon Resonance (SPR) offers a powerful tool for label-free and non-invasive characterization of biomolecular interactions. To date, several experimental configurations, based on two fundamental physical phenomena, e.g., attenuated total reflection and diffraction, have been developed to measure the SPR signal generated due to the resonant interactions between incident light and plasma waves on the metal surface. These configurations are divided into three categories: grating-based, prism-based, and waveguide-based coupling. Among such techniques, one of the prism-based SPR coupling schemes, popularly known as Kretschmann configuration, is most widely used due to its high sensitivity, operational simplicity, lower cost, and real-time detection. This chapter explains the basic instrumentation and reviews the recent trends in the development of Kretschmann configuration-based SPR biosensors with its applications.

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Polarimetric Measurements of Surface Chirality Based on Linear and Nonlinear Light Scattering

Cited by 11 publications

References 264 publications

Nanophotonic Approaches for Chirality Sensing

Nanophotonic Approaches for Chirality Sensing

Detection of biosignatures in terrestrial Mars analogs: Strategical and technical assessments

Surface Plasmon Resonance Biosensors Based on Kretschmann Configuration: Basic Instrumentation and Applications

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