The Hamiltonian formulation of guiding-center Vlasov–Maxwell equations, which contain dipole contributions to the guiding-center polarization and magnetization, is presented in terms of a guiding-center Hamiltonian functional that is derived from the exact guiding-center Vlasov–Maxwell energy conservation law, and an antisymmetric functional bracket that satisfies the Jacobi property. Exact energy-momentum and angular momentum conservation laws are expressed in the Hamiltonian form, and the guiding-center Vlasov–Maxwell entropy functional is shown to be a Casimir functional.