Polarized spatial frequency domain imaging of heart valve fiber structure

Goth, Will; Yang, Bin; Lesicko, John; Allen, Alicia C.B.; Sacks, Michael S.; Tunnell, James W.

doi:10.1117/12.2212812

Cited by 10 publications

(7 citation statements)

References 25 publications

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“…It would also be useful to better understand the contributions of the elastin sheath to the chordae's overall mechanical behaviors through testing the same tissues before and after sheath removal. Other useful information could be found through new microstructural quantification technologies, such as polarized spatial frequency domain imaging, allowing for an understanding of the load-dependent collagen fiber architecture, especially at the insertion regions [66,67,69].…”

Section: Closing Remarks and Future Prospectsmentioning

confidence: 99%

Mechanics and Microstructure of the Atrioventricular Heart Valve Chordae Tendineae: A Review

Ross

Zheng

et al. 2020

Bioengineering

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The atrioventricular heart valves (AHVs) are responsible for directing unidirectional blood flow through the heart by properly opening and closing the valve leaflets, which are supported in their function by the chordae tendineae and the papillary muscles. Specifically, the chordae tendineae are critical to distributing forces during systolic closure from the leaflets to the papillary muscles, preventing leaflet prolapse and consequent regurgitation. Current therapies for chordae failure have issues of disease recurrence or suboptimal treatment outcomes. To improve those therapies, researchers have sought to better understand the mechanics and microstructure of the chordae tendineae of the AHVs. The intricate structures of the chordae tendineae have become of increasing interest in recent literature, and there are several key findings that have not been comprehensively summarized in one review. Therefore, in this review paper, we will provide a summary of the current state of biomechanical and microstructural characterizations of the chordae tendineae, and also discuss perspectives for future studies that will aid in a better understanding of the tissue mechanics–microstructure linking of the AHVs’ chordae tendineae, and thereby improve the therapeutics for heart valve diseases caused by chordae failures.

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Section: Closing Remarks and Future Prospectsmentioning

confidence: 99%

Mechanics and Microstructure of the Atrioventricular Heart Valve Chordae Tendineae: A Review

Ross

Zheng

et al. 2020

Bioengineering

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“…Tissue collagen fiber orientations were determined following the methods described in our previous work (Jett et al 2020), and the theory outlined in (Goth et al 2016). In pSFDI, as is rotated from 0° to 180° the intensity of the reflected polarized light I returns a bimodal response due to the birefringent response of the collagen fibers (Fig.…”

Section: Analysis Of Psfdi-based Collagen Microstructural Datamentioning

confidence: 99%

“…This is achieved by utilizing an integrated instrument (Fig. 1c) that facilitates uniaxial mechanical testing and collagen fiber microstructural quantification based on polarized spatial frequency domain imaging (pSFDI) (Goth et al 2016). Through this pSFDI method, the load-dependent changes in the CFA, including the collagen fiber orientation and the degree of optical anisotropy, of the CT-leaflet insertion are quantified by using the same specimen without the use of chemical fixatives, offering an advantage compared to the previous histological or in vitro flow loop study (Chen et al 2004;Padala et al 2010).…”

Section: Introductionmentioning

confidence: 99%

Quantification of load-dependent changes in the collagen fiber architecture for the strut chordae tendineae-leaflet insertion of porcine atrioventricular heart valves

Ross

Hsu

Baumwart

et al. 2020

Biomech Model Mechanobiol

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Atrioventricular heart valves (AHVs) regulate the unidirectional flow of blood through the heart by opening and closing of the leaflets, which are supported in their functions by the chordae tendineae (CT).The leaflets and CT are primarily composed of collagen fibers that act as the load-bearing component of the tissue microstructures. At the CT-leaflet insertion, the collagen fiber architecture is complex, and has been of increasing focus in the previous literature. However, these previous studies have not been able to quantify the load-dependent changes in the tissue's collagen fiber orientations and alignments. In the present study, we address this gap in knowledge by quantifying the changes in the collagen fiber architecture of the mitral and tricuspid valve's strut CT-leaflet insertions in response to the applied loading by using a unique approach, which combines polarized spatial frequency domain imaging with uniaxial mechanical testing. Additionally, we characterized these microstructural changes across the same specimen without the need for tissue fixatives. We observed increases in the collagen fiber alignments in the CT-leaflet insertion with increased loading, as described through the degree of optical anisotropy.Furthermore, we used a leaflet-CT-papillary muscle entity method during uniaxial testing to quantify the chordae tendineae mechanics, including the derivation of the Ogden-type constitutive modeling parameters. Results from this study provide a valuable insight into the load-dependent behaviors of the strut CT-leaflet insertion, offering a research venue to better understand the relationship between tissue mechanics and the microstructure, which will contribute to a deeper understanding of AHV biomechanics.

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“…There have been many previous studies using PLI phantoms, reviewed in detail by Chue-Sang et al 18 In some cases their main objective is to assess whether the system is able to accurately resolve polarization properties and anisotropy; [19][20][21] similarly groups have used phantoms to characterize an imaging system's responses to structural features; 22 alternatively phantoms have been used to validate the mathematical formalism of decomposition methods and simulate light-tissue interactions. [23][24][25] In this proceeding, we aim to probe several outstanding challenges in interpreting reflectance PLI results by investigating potential PLI phantoms for these effects.…”

Section: Introductionmentioning

confidence: 99%

Reflectance full Mueller matrix polarimetry for microstructural validation of diffusion magnetic resonance imaging

Bonaventura

Morara²,

Carlson³

et al. 2023

Polarized Light and Optical Angular Momentum for Biomedical Diagnostics 2023

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Knowledge of fiber microstructure and orientation in the brain is critical for understanding the pathogenesis and progression of neurodegenerative diseases such as Alzheimer’s disease. Diffusion magnetic resonance imaging (dMRI) is a noninvasive imaging modality that can generate mappings of nerve fiber orientation. Due to rigorous levels of mathematical modeling involved in reconstructing dMRI data; and limited spatial resolution, there arises a need to validate the biological accuracy of collected dMRI data. Polarized light imaging (PLI) has been shown to have potential for microstructural validation due to the anisotropy in many biological tissues, particularly in myelin sheaths surrounding nerve fibers in the brain. Using PLI for this purpose is appealing because it is directly sensitive to tissue structure and can be done at high resolution. While several studies have had success using PLI for fiber mapping, continuing to advance this modality, particularly reflectance based PLI systems, could provide a valuable avenue for in vivo neural imaging. In order to reach the full potential of reflectance PLI systems, some key questions remain such as the ability of PLI to resolve crossing fibers, and the sensitivity of reflectance PLI to fiber inclination. Tissue phantoms are one potential method to isolate these issues in order to investigate them. In this proceeding, a five-wavelength reflectance Mueller matrix polarimeter is used for imaging of promising PLI tissue phantoms as well as regions of interest in fixed ferret brain samples. The retardance, diattenuation and depolarization mappings are derived from the Mueller matrix and studied in order to assess the sensitivity of this polarimeter configuration to different fiber orientations.

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Polarized spatial frequency domain imaging of heart valve fiber structure

Cited by 10 publications

References 25 publications

Mechanics and Microstructure of the Atrioventricular Heart Valve Chordae Tendineae: A Review

Mechanics and Microstructure of the Atrioventricular Heart Valve Chordae Tendineae: A Review

Quantification of load-dependent changes in the collagen fiber architecture for the strut chordae tendineae-leaflet insertion of porcine atrioventricular heart valves

Reflectance full Mueller matrix polarimetry for microstructural validation of diffusion magnetic resonance imaging

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