Polarographic Behavior of Gemfibrozil in the Presence of Dissolved Oxygen and Its Analytical Application

Xu, Minmin; Song, Junfeng; Guo, Wei; Li, Ning

doi:10.1002/elan.200302906

Cited by 5 publications

(3 citation statements)

References 17 publications

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“…Several analytical techniques such as Chromatography, [4][5][6][7][8][9][10][11] Spectrofluorimetry, [12] Polarography, [13] and Potentiometry [14] have been reported in the analysis of GEM. These methods have impediments like high duration for analysis, sample pretreatment, expensive instrumentations, and low selectivity and sensitivity in a few cases.…”

Section: Introductionmentioning

confidence: 99%

Rapid Electrochemical Investigation of Gemfibrozil Using NiONPs/Multiwalled Carbon Nanotube Modified Carbon Paste Electrode: Analysis of Human Urine Sample and Antimicrobial Activity

Kathrikenahalli Somashekarappa,

Basavaraju,

Nelligere Arakeshwaraiah

et al. 2023

ChemistrySelect

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In this study, nickel oxide nanoparticles (NiONPs) were produced by the co‐precipitation method and characterized by scanning electron microscopy, X‐ray diffraction (XRD), Fourier transform‐infrared and Ultraviolet‐visible spectroscopy. XRD analysis showed an average crystal size of 6 nm, while SEM analysis exemplified the oblong form with a particle size of 12 nm. As‐prepared NiONPs were combined with multiwalled carbon nanotubes (MWCNTs) and graphite powder to prepare NiONPs‐MWCNTs modified carbon paste electrode (MCPE). The fabricated NiONPs‐MWCNTsMCPE sensor was used to analyze Gemfibrozil (GEM) in pharmaceutical formulations. Electrochemical methods such as cyclic voltammetry, differential pulse voltammetry, and electrochemical impedance spectroscopy employed in sensor characterization and electroanalysis of GEM. The sensor exhibited excellent electrochemical behavior towards GEM. It showed a lower limit of detection (LOD, 2.7×10−8 M), the limit of quantification (LOQ, 9.07×10−8 M), higher sensitivity, higher linear range, and long‐term stability compared to the reported methods. The NiONPs‐MWCNTsMCPE sensor was evaluated for practical application by performing spiking tests in pharmaceutical formulations and human urine samples, demonstrating significant recovery, high effectiveness, and accuracy. Further, nanoparticles manifested promising antibacterial action against Staphylococcus aureus, E. coli, Klebsiella aerogenes, Pseudomonas aeruginosa, and Klebsiella aerogenes.

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Section: Introductionmentioning

confidence: 99%

Rapid Electrochemical Investigation of Gemfibrozil Using NiONPs/Multiwalled Carbon Nanotube Modified Carbon Paste Electrode: Analysis of Human Urine Sample and Antimicrobial Activity

Kathrikenahalli Somashekarappa,

Basavaraju,

Nelligere Arakeshwaraiah

et al. 2023

ChemistrySelect

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“…Thus an accurate and sensitive quantification of GEM in pharmaceutical formulations and biological fluids such as blood plasma is required for quality-control procedures in the pharmaceutical industry and physiological pharmaco-kinetics studies. Reviewing the articles published in journals shows that different methods such as high performance liquid chromatography [4][5][6], gas chromatography [7,8], spectrofluorimetry [9][10][11], thin-layer chromatography [12], and polarography [13] have been reported for GEM measurement in clinical and pharmaceutical samples. Although these methods have good sensitivities in the determination of GEM, they suffer from limitations such as expensive equipment, operation complexity, and high consumption of reagents.…”

Section: Introductionmentioning

confidence: 99%

Construction and characterization of GCE/MWCNT/Au-NP as a new impedimetric and voltammetric sensor for determination of gemfibrozil in pharmaceutical and biological samples

Chamjangali¹,

Reskety²,

Goudarzi³

et al. 2019

Biomed. Phys. Eng. Express

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A novel electrochemical sensor was constructed for the impedimetric and voltammetric determination of gemfibrozil (GEM) by modification of the glassy carbon electrode (GCE) using multi-walled carbon nanotubes (MWCNTs) and gold nanoparticles (Au-NPs). The inherent properties of MWCNTs such as their high surface area and high conductivity, and the capability of fast electron transfer of Au-NPs were taken into account in constructing the sensor. Scanning electron microscopy (SEM), energy dispersive x-ray (EDX), and electrochemical impedance spectroscopy (EIS) were used for the characterization of the MWCNTs/Au-NPs modified GCE (GCE/MWCNT/Au-NP) surface. The redox behavior of GEM on the surface of GCE/MWCNT/Au-NP was studied by voltammetric techniques. After optimizing the effective experimental parameters, the sensor's response toward increasing GEM concentration was studied by square wave voltammetry (SWV) and EIS. The results obtained showed linear responses in the GEM concentration ranges of 0.15-45.0 and 0.10-45.0 μmol L −1 for SWV and EIS, respectively. The experimental 3σ detection limits were 0.10 and 0.074 μmol L −1 for SWV and EIS, respectively. The repeatability of 1.07% and reproducibility of 5% were achieved for five replicate determinations of 15.0 μmol L −1 of GEM. The sensor efficiency was investigated by its application in the analysis of the real samples pharmaceutical and spiked human serum, and the results obtained were satisfactory.

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“…In this case, some sulfur- and nitrogen-containing organic compounds are protonated and adsorbed on the electrode surface to reduce overpotential and produce catalytic hydrogen waves. Using catalytic hydrogen waves, sensing determination of some platinum group metal ions and certain organic compounds containing lone pair electrons could be realized. − …”

mentioning

confidence: 99%

Detection of Phosphate in Human Blood Based on a Catalytic Hydrogen Wave at a Molybdenum Phosphide Modified Electrode

et al. 2019

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Detection of inorganic phosphate is very important in environmental and health care applications. In this work, we found that phenomenon similar to “catalytic hydrogen wave” occurred on a molybdenum phosphide (MoP) modified electrode in the presence of phosphate, that is, a new wave of catalytic hydrogen evolution appeared before the normal hydrogen evolution reaction. The catalytic hydrogen wave arose from a structure similar to phosphomolybdic acid (noted as MoPO), which was formed by the interaction between phosphate and molybdenum oxides on the surface of the MoP modified electrode, resulting in the altered surface structure and adjusted interface catalytic activity. A novel phosphate electrochemical sensor was constructed based on this phenomenon with a linear range from 0.10 to 20.0 mmol·L–1, an actually determined minimum concentration of 0.030 mmol·L–1, and recoveries of 94%–107%, and this sensor was successfully applied to the detection of phosphate in human blood. Furthermore, this work proposes a new sensing method based on catalytic hydrogen waves on the modified electrodes.

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Polarographic Behavior of Gemfibrozil in the Presence of Dissolved Oxygen and Its Analytical Application

Cited by 5 publications

References 17 publications

Rapid Electrochemical Investigation of Gemfibrozil Using NiONPs/Multiwalled Carbon Nanotube Modified Carbon Paste Electrode: Analysis of Human Urine Sample and Antimicrobial Activity

Rapid Electrochemical Investigation of Gemfibrozil Using NiONPs/Multiwalled Carbon Nanotube Modified Carbon Paste Electrode: Analysis of Human Urine Sample and Antimicrobial Activity

Construction and characterization of GCE/MWCNT/Au-NP as a new impedimetric and voltammetric sensor for determination of gemfibrozil in pharmaceutical and biological samples

Detection of Phosphate in Human Blood Based on a Catalytic Hydrogen Wave at a Molybdenum Phosphide Modified Electrode

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