Polarography as a technique of choice for the evaluation of total antioxidant activity: The case study of selected <i>Coprinus Comatus</i> extracts and quinic acid, their antidiabetic ingredient

Karaman, Maja; Tešanović, Kristina; Gorjanović, Stanislava; Pastor, Ferenc T.; Simonović, Mladen; Glumac, Miodrag; Pejin, Boris

doi:10.1080/14786419.2019.1628753

Cited by 30 publications

(21 citation statements)

References 23 publications

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“…Antioxidant activity (AO) is considered to be an important feature of edible mushrooms in the prevention of oxidative stress [1,2,3]. Their antioxidants may well contribute to maintaining their physiological balance by neutralisation of free radicals (with stress on reactive oxygen species), without toxic or mutagenic effects, as opposed to synthetic antioxidants [3,4]. Generally speaking, it is believed that phenolics are primarily responsible for AO [1,5,6].…”

Section: Introductionmentioning

confidence: 99%

Fatty Acids Predominantly Affect Anti-Hydroxyl Radical Activity and FRAP Value: The Case Study of Two Edible Mushrooms

Karaman

Atlagić

Novaković³

et al. 2019

Antioxidants

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Compared to plants, nowadays mushrooms attract more attention as functional foods, due to a number of advantages in manipulating them. This study aimed to screen the chemical composition (fatty acids and phenolics) and antioxidant potential (OH•, 2,2-diphenyl-1-picrylhydrazyl (DPPH•) and ferric reducing ability of plasma (FRAP)) of two edible mushrooms, Coprinus comatus and Coprinellus truncorum, collected from nature and submerged cultivation. Partial least square regression analysis has pointed out the importance of some fatty acids—more precisely, unsaturated fatty acids (UFAs) followed by fatty acids possessing both short (C6:0 and C8:0) and long (C23:0 and C24:0) saturated chains—and phenolic compounds (such as protocatechuic acid, daidzein, p-hydroxybenzoic acid, genistein and vanillic acid) for promising anti-OH•, FRAP and anti-DPPH• activities, respectively. However, other fatty acids (C16:0, C18:0 and C18:3n3) along with the flavonol isorhamnetin are actually suspected to negatively affect (by acting pro-oxidative) the aforementioned parameters, respectively. Taken together, design of new food supplements targeting oxidative stress might be predominantly based on the various UFAs combinations (C18:2n6, C20:1, C20:2, C20:4n6, C22:2, C22:1n9, etc.), particularly if OH• is suspected to play an important role.

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Section: Introductionmentioning

confidence: 99%

Fatty Acids Predominantly Affect Anti-Hydroxyl Radical Activity and FRAP Value: The Case Study of Two Edible Mushrooms

Karaman

Atlagić

Novaković³

et al. 2019

Antioxidants

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“…However, a recent study that determined the total antioxidant activity of the selected extracts of the mushroom C. comatus using a polarographic hydroxoperhydroxomercury (II) complex (HPMC) formation assay found that quinic acid exhibited the most promising antioxidant potential. This compound belongs to the class of cyclic polyols, an under-appreciated class of organic compounds, compared with aromatic (poly) phenolics [ 48 ]. Two main polysaccharide components (Ccp-I-A, Ccp-I-B) from the fruit bodies of C. comatus also have a strong antioxidant effect, whose scavenging activity on superoxide anions could reach 95% that of ascorbic acid [ 49 ].…”

Section: Resultsmentioning

confidence: 99%

Chemical composition, nutritional profile and in vivo antioxidant properties of the cultivated mushroom Coprinus comatus

et al. 2020

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This study investigated the chemical and nutritional profile and antioxidative properties of cultivated Coprinus comatus . Proximate analysis revealed that C. comatus is rich in carbohydrates, dietary fibres and proteins, and could also be a valuable source of phenolics. Additionally, fat content is low, consisting mainly of polyunsaturated and omega-3 fatty acids. Furthermore, the safety profile of C. comatus is satisfactory, with all elements of toxicological importance within the proposed limits. Oral treatment with C. comatus for 42 days improved the antioxidant capabilities and ameliorated carbon tetrachloride-induced liver damage in rats, marked by decreased serum aminotransferase levels and lipid peroxidation intensity. Glutathione concentrations increased in a dose-dependent manner. Histological morphometric and immunohistochemical analysis confirmed antioxidative and hepatoprotective potential. These findings imply that cultivated C. comatus could be considered a nutraceutical, having beneficial nutrient and therapeutic properties.

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“…In accordance with our findings, C. bursa-pastoris extract obtained using 0.01N H 2 SO 4 -water has contained quinic acid (95.6 mg/g), malic acid (68.3 mg/g), citric acid (27.4 mg/g), and oxalic acid (2.4 mg/g) (Grosso et al, 2011). Plant-derived quinic acid are reported to have wide ranging biological activities (antidiabetic) and a high potential as antioxidants high scavenging DPPH activity) (Janjušević et al, 2017;Karaman et al, 2019).…”

Section: Re Sults and Discussionmentioning

confidence: 99%

Antihemorrhoidal activity of organic acids ofCapsella bursa‐pastorison croton oil‐induced hemorrhoid in rats

et al. 2020

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This study was aimed to investigate the antihemorrhoidal effects of ethanol (CBE) and water extracts (CBW) of Capsella bursa‐pastoris, an edible plant and a precipitant (CBW‐1) obtained from the CBW in croton oil (CO)‐induced hemorrhoid model in rats. CBW‐1 was contain three organic acids, citric acid (36.09%), malic acid (35.56%), and quinic acid (17.73%). Hemorrhoids were evaluated by histopathology of recto‐anal tissues and biochemical parameters in plasma and recto‐anal tissues of rats. CBW, CBE, and CBW‐1 significantly reduced hemorrhagic necrotic enteritis induced by CO. CO also increased the cytokines and lipid peroxidation (LPO) in serum, and myeloperoxidase (MPO) activity and LPO in recto‐anal tissues, and reduced the GSH, CAT, GPx, and SOD levels in serum and recto‐anal tissues. However, CBE, CBW, and CBW‐1 ameliorated the levels of the cytokines, LPO, MPO, and the antioxidants. Our results conclude that the curative effect of Capsella bursa‐pastoris is closely related with its organic acids constituents, citric, malic, and quinic acids. Practical applications The fresh leaves of Capsella bursa‐pastoris are edible, eaten raw or cooked, and also used in salad. It has a widespread traditional usage in the treatment of the hemorrhoids in the Anatolia and in the Middle East Countries. According to our literature survey, any scientific evidence has not been found in the literature that C. bursa‐pastoris could be used in the treatment of hemorrhoids. Therefore, in the current study, we aimed to investigate the antihemorrhoidal and antioxidant effects of ethanol and water extracts, and a precipitant (CBW‐1) obtained from the CBW of C. bursa‐pastoris in croton oil (CO)‐induced hemorrhoid model in rats. The current results showed that its water extract and CBW‐1 containing three organic acids, citric acid (36.09%), malic acid (35.56%), and quinic acid (17.73%) significantly reduced the hemorrhagic necrotic enteritis induced by CO ameliorating the levels of the cytokines, LPO, MPO, and the antioxidants. Our results conclude that the curative effect of C. bursa‐pastoris is closely related with its organic acids constituents, citric, malic, and quinic acids.

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Polarography as a technique of choice for the evaluation of total antioxidant activity: The case study of selected Coprinus Comatus extracts and quinic acid, their antidiabetic ingredient

Cited by 30 publications

References 23 publications

Fatty Acids Predominantly Affect Anti-Hydroxyl Radical Activity and FRAP Value: The Case Study of Two Edible Mushrooms

Fatty Acids Predominantly Affect Anti-Hydroxyl Radical Activity and FRAP Value: The Case Study of Two Edible Mushrooms

Chemical composition, nutritional profile and in vivo antioxidant properties of the cultivated mushroom Coprinus comatus

Antihemorrhoidal activity of organic acids ofCapsella bursa‐pastorison croton oil‐induced hemorrhoid in rats

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