Pold4 subunit of replicative polymerase δ promotes fork slowing at broken templates

Kojima, Kota; Ohkubo, Hiromori; Kawasumi, Ryotaro; Hirota, Kouji

doi:10.1016/j.dnarep.2024.103688

DNA Repair

2024

DOI: 10.1016/j.dnarep.2024.103688

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Pold4 subunit of replicative polymerase δ promotes fork slowing at broken templates

Kota Kojima,

Hiromori Ohkubo,

Ryotaro Kawasumi

et al.

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2024

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Cited by 2 publications

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p12 isoform‐2 is a regulatory subunit of human DNA polymerase delta and is dysregulated in various cancers

Sahu,

Thakur,

Subhadarsini

et al. 2024

FEBS Letters

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Dysregulation of human DNA polymerase delta (Polδ) subunits is associated with genome instability and pathological disorders. Genome databases suggest the expression of several spliced variants of subunits which may alter Polδ function. Here, we analyzed the protein‐encoding variants of the Polδ subunit p12 and their association with cancer. p12 isoform‐2 (p12*) encodes a 79 aa protein with a C‐terminal tail distinct from the previously characterized p12. Like p12, p12* dimerizes and interacts with p125 and p50 subunits and is thus an integral component of Polδ. Further, we observed dysregulated p12* expression in low‐grade glioma, renal, thyroid, and pancreatic carcinomas. This study identifies a previously unrecognized Polδ complex and highlights a possible regulatory role of p12 variants in cellular phenotypes.

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p12 isoform‐2 is a regulatory subunit of human DNA polymerase delta and is dysregulated in various cancers

Sahu,

Thakur,

Subhadarsini

et al. 2024

FEBS Letters

View full text Add to dashboard Cite

show abstract

Molecular mechanisms of avian immunoglobulin gene diversification and prospect for industrial applications

Seo,

Hirota,

Ohta

2024

Front. Immunol.

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Poultry immunoglobulin genes undergo diversification through homologous recombination (HR) and somatic hypermutation (SHM). Most animals share a similar system in immunoglobulin diversification, with the rare exception that human and murine immunoglobulin genes diversify through V(D)J recombination. Poultry possesses only one functional variable gene for each immunoglobulin heavy (HC) and light chains (LC), with clusters of non-productive pseudogenes upstream. During the B cell development, the functional variable gene is overwritten by sequences from the pseudo-variable genes via a process known as gene conversion (GC), a kind of HR. Point mutations caused in the functional variable gene also contribute to immunoglobulin diversification. This review discusses the latest findings on the molecular mechanisms of antibody gene diversification in poultry, using chickens as a model. Additionally, it will outline how these basic research findings have recently been applied especially in the medical field.

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Pold4 subunit of replicative polymerase δ promotes fork slowing at broken templates

Cited by 2 publications

References 40 publications

p12 isoform‐2 is a regulatory subunit of human DNA polymerase delta and is dysregulated in various cancers

p12 isoform‐2 is a regulatory subunit of human DNA polymerase delta and is dysregulated in various cancers

Molecular mechanisms of avian immunoglobulin gene diversification and prospect for industrial applications

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