We study the $\Lambda(1405)$ resonance with $I(J^{P})=0(1/2^{-}) $ in the context of the pentaquark hypothesis in the nuclear medium. To explore the influence of the nuclear medium on the physical parameters of $\Lambda(1405)$, we propose a molecular-type structure involving admixtures of $K^{-}p$ and $\bar{K}^{0}n$, correlated with the nuclear matter density. Our analysis reveals a substantial shift in mass and residue, approximately $20\%$ and $38\%$, respectively. These findings have significant implications for experimental researchers aiming to identify in-medium characteristics of hyperon resonances.