Policosanol composition, antioxidant and anti-arthritic activities of milk thistle (Silybium marianum L.) oil at different seed maturity stages

Harrabi, Saoussem; Ferchichi, A.; Bacheli, Asma; Fellah, Hayet

doi:10.1186/s12944-018-0682-z

Cited by 48 publications

(31 citation statements)

References 37 publications

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“…Greater SOD and GPx levels, as seen in the OCT group, would be beneficial, as SOD eliminates harmful free oxygen radicals 25 and GPx reduces the damaging effects of lipid peroxidation. 26 These improvements are believed to be due to the antioxidant effects of octacosanol, as one study found strong antiradical properties of octacosanol (96.42% and 90.35% antiradical activity from the DPPH and ABTS radical scavenging assays, respectively), 27 while another study demonstrated the ability of octacosanol to decrease oxidative stress markers in an animal model. 28 This form of sports training may also lead to an increase in systemic inflammation, as inflammatory markers, such as C-reactive protein and interleukin-6, have been shown to be correlated with elevated lipid profiles and oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

Improvement of Lipids and Reduction of Oxidative Stress With Octacosanol After Taekwondo Training

Lee¹,

Scott²,

Pekas³

et al. 2019

International Journal of Sports Physiology and Performance

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Purpose: Athletes in combat sports undergo rapid changes in body weight prior to competition in order to gain a size advantage over their opponent. However, these large weight changes with concomitant high-intensity exercise training create poor lipid profiles and high levels of oxidative stress, which can be detrimental to health and sport performance. Therefore, the purpose of this study was to investigate the ability of the nutritional supplement octacosanol to combat the physiological detriments that occur in taekwondo players during rapid weight loss with high-intensity exercise training. Methods: A total of 26 male taekwondo players were randomly divided into 2 groups: An experimental group performed a 5% weight-loss and taekwondo training program with 40-mg octacosanol intake (OCT; n = 13) for 6 d, and a control group performed the same weight-loss and taekwondo training program with a placebo (CON; n = 13). Results: There were significant (P < .05) group × time interactions for low-density lipoprotein and triglycerides, which significantly decreased (Δ18 [5] mg/dL and Δ80 [7] mg/dL, respectively), and high-density lipoprotein, which significantly increased (Δ10 [7] mg/dL), in the OCT group compared with the CON group. There were also significant (P < .05) group × time interactions for superoxide dismutase (SOD), glutathione peroxidase (GPx), and malondialdehyde (MDA), with SOD increasing (Δ226 [121] U/gHb) in the OCT group, while GPx decreased (Δ20 [13] U/gHb) and MDA increased (Δ72 [0.04] nmol/mL) in the CON group. Conclusion: These results suggest that octacosanol may be a beneficial supplement to protect against the poor cholesterol levels and oxidative stress that occurs during taekwondo training.

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Section: Discussionmentioning

confidence: 99%

Improvement of Lipids and Reduction of Oxidative Stress With Octacosanol After Taekwondo Training

Lee¹,

Scott²,

Pekas³

et al. 2019

International Journal of Sports Physiology and Performance

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“…Argan oil, which contains tocopherols, polyphenols, squalene, triterpene alcohols, and sterols, has been used in skin care products and the treatment of skin infections [20]. A previous study further showed the protective effects of vitamin E on keratinocyte damage in a cell culture experiment [21], while Harrabi et al [22] reported that the policosanol level in seed oils may contribute to their antioxidant. Phytosterols have also shown positive effects on skin barrier recovery [23].…”

Section: Phytochemical Contents Of Usmmentioning

confidence: 99%

Protective Effects of Unsaponifiable Matter from Perilla Seed Meal on UVB-induced Damages and the Underlying Mechanisms in Human Skin Fibroblasts

et al. 2019

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Unsaponifiable matter (USM) from perilla seed meal contains numerous phytochemicals, including tocopherols, phytosterols, squalene, and policosanols, that exhibit antioxidant and health-promoting properties. In this study, the protective effects of USM on UVB-induced skin aging were investigated in Hs68 cells. UVB irradiation decreased cell viability by 26% compared to the control. However, USM blocked UVB-induced cytotoxicity. Moreover, USM treatment significantly decreased the UVB-induced production of reactive oxygen species and attenuated the UVB-induced production and mRNA expression of matrix metalloproteinases (MMPs) by inhibiting the phosphorylation of mitogen-activated protein kinases and activator protein 1 (AP-1). Furthermore, UVB exposure led to a 49.4% reduction in collagen synthesis. However, USM treatment restored collagen synthesis through upregulation of the transforming growth factor beta (TGF-β)/Smad2/3 pathways. These data indicate that USM regulates the production of MMPs and collagen by modulation of the TGF-β/Smad pathway and AP-1 activity, suggesting that USM may be a useful anti-photoaging ingredient.

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“…S. marianum can therefore also be used in human nutrition [ 12 ]. A recent study demonstrated the antatritic and antioxidant effects of milk thistle oil proving the potential to utilize these effects in the food and pharmaceuctical industries [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Influence of Milk Thistle (Silybum marianum) Seed Cakes on Biochemical Values of Equine Plasma Subjected to Physical Exertion

Dočkalová

Zeman

Horký

2021

Animals

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Veterinarians can recommend milk thistle for the treatment of equine liver disease and laminitis. Milk thistle seed cakes were fed in the range of normal feed doses in this study. The milk thistle seed cakes were fed (twice a day) to the experimental group of the horses (n = 5) and biochemical blood markers (TP, Albumin, ALT (alanine transaminase), AST (aspartate transaminase), ALP (alkaline phosphatase), GGT (gamma-glutamyltransferase), Bilirubin, Cholesterol, HDL (high-density lipoprotein), LDL (low-density lipoprotein), TAG (triacylglycerol), BHB (beta-hydroxybutyric acid), NEFA (non-esterified fatty acids), creatine kinase, creatinine, Urea, GSH-Px (glutathione peroxidase), TAS (total antioxidant status), lactate, glucose, cortisol, Ca, Pi) were monitored. The control group of horses (n = 5), bred and trained in the same conditions, was used for comparison. The control group received the entire feed dose as accepted by the horses in the experimental group before the beginning of the experiment. The aim was to find out whether the preparation of milk thistle seed cakes could have positive effects on the health of the horses. All ten horses received one feeding form before the beginning of the experimental monitoring. All horses were exposed to heavy physical exercise (regular combined driving training) after 56 days of milk thistle seed cakes feeding (up to 400 g/day). Three blood samples were taken (before physical exercise; about 15 min and 60 min after physical exercise). Significant differences (p < 0.05) were detected in the values of AST, NEFA, cortisol and Pi in the experimental group. The exercise effect was detected in the values of albumin, lactate, cortisol, NEFA, and calcium. Our results suggest that the feeding of milk thistle seed cakes could have a positive effect on the health of the horses.

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Policosanol composition, antioxidant and anti-arthritic activities of milk thistle (Silybium marianum L.) oil at different seed maturity stages

Cited by 48 publications

References 37 publications

Improvement of Lipids and Reduction of Oxidative Stress With Octacosanol After Taekwondo Training

Improvement of Lipids and Reduction of Oxidative Stress With Octacosanol After Taekwondo Training

Protective Effects of Unsaponifiable Matter from Perilla Seed Meal on UVB-induced Damages and the Underlying Mechanisms in Human Skin Fibroblasts

Influence of Milk Thistle (Silybum marianum) Seed Cakes on Biochemical Values of Equine Plasma Subjected to Physical Exertion

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