Review of Policy Research (RPR) is a journal of public policy. An important tradition of the journal is its emphasis on multidisciplinary perspectives. Public policy can combine political science and other social science approaches with disciplines such as psychology, ecology, geography, and engineering. Multidisciplinarity is fruitful for all fields of public policy. It has a special tradition in the fields of science, technology, environment, energy and health, among others. What is often interesting here is the special relationship between technological, social, and political change.This sixth and last issue of the RPR volume 38 (2021) contains contributions dealing with different types of technologies and the associated policies and societal and political implications of technological change. New technologies and digitalization processes do not only affect different policy areas, such as labor market, health, agriculture, and environment. These processes also have transformative power for science and the way we research and teach them in public policy. This issue raises some of the challenges and opportunities that new technologies present for policy scholars. With a focus on technological change and the digital transformation, the issue represents one of RPR's main goals: to analyze the multiple interactions of technologies with the policy process.The emergence of Big Data analytics technologies offers public policy scholars new opportunities to integrate these sources into their research and teaching. El-Taliawi et al. (2021) examine the extent to which Big Data technologies are already being used in public policy. Using a large comparative study of research output and education policy, they find that only individual institutions are currently taking advantage of the opportunities offered by new technologies. They conclude that integrating Big Data techniques in both research and teaching is a critical task to increase the future relevance of political science.