Polifenóis No Vinho: Resveratrol E Seus Benefícios

Martins, Pâmela Padovani; Nicoletti, María Aparecida

doi:10.14450/2318-9312.v28.e4.a2016.pp216-225

Cited by 3 publications

(2 citation statements)

References 25 publications

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“…Resveratrol is present in several plants, mainly in the skin of epidermal cells and the seeds of red grapes and their derivatives, but there is a low amount in the pulp. In animal and human pharmacokinetic studies, which are limited, resveratrol is absorbed in the gastrointestinal tract after ingestion [5] and undergoes rapid metabolism in the body [6] since the half-life of resveratrol is short and the effect is transient, so further clinical studies are needed to assess the effects of a high dose [7]. Its bioavailability after oral administration is very low, despite absorption reaching 70%.…”

Section: Resveratrolmentioning

confidence: 99%

“…There are also experimental studies highlighting the regulatory mechanisms and immunomodulatory role of resveratrol in vivo and in vitro. These data reveal the promising role of resveratrol in the prevention and therapy of a wide variety of chronic diseases and several infectious diseases, including Chagas disease [6]. The objective of this systematic review is to show how the compound resveratrol acts in different stages of the development of the parasite T. cruzi, and how it can be efficient in the combat of Chagas' disease.…”

Section: Introductionmentioning

confidence: 99%

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"Therapeutic Uses of Resveratrol Compound in Chagas Disease - A Literature Review"

Silva

2022

BJSTR

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Chagas disease is a parasitic disease caused by Trypanosoma cruzi and is also a highly neglected tropical disease. In chronic stages of the disease there may be brain and cardiac inflammation that can lead to death. The nitroxidative effect of cells in response to infection contributes to disease progression by inducing tissue damage. In this systematic review, experiments are presented and discussed that seek to understand the use of antioxidants to combat harmful ROS (reactive oxygen species), in order to reduce oxidative damage to tissue during disease progression. One of the viable forms of therapy to control the chronic form of Chagas Disease are sirtuins, molecules that are part of histone deacetylases (HDAC) of the class III family. The compound presented in this review is resveratrol, which is a natural polyphenol found in grape seeds that acts as a sirtuin 1 agonist (SIRT1), this compound activates SIRT1 during parasitic infections. Studies on SIRT1 are linked to its agonist resveratrol and present a good future perspective for new trypanocidal drugs, as they have a relationship with oxidative stress and an anti-inflammatory effect related to neuroinflammation and cardioprotective effects by preventing cardiac hypertrophy. However, there is a need for clinical tests and studies of Resveratrol in humans to further explore the anti-inflammatory effects that the compound has during the oxidative stress caused by T. cruzi infection. Consequently, this would enable the use of antioxidants, such as Resveratrol, in the treatment of Chagas disease. drugs to control this late inflammation have been researched, since

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Section: Resveratrolmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

"Therapeutic Uses of Resveratrol Compound in Chagas Disease - A Literature Review"

Silva

2022

BJSTR

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Effects of grape juice, red wine and resveratrol on liver parameters of rat submitted high-fat diet

Bedê

Jesuz

Souza

et al. 2020

An. Acad. Bras. Ciênc.

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This work evaluated the effect of grape juice, red wine and resveratrol in liver parameters of rats submitted to high-fat diet. Experimental model was conducted with groups of adult females Rattus norvegicus: control (CG); high-fat (HG); grape juice (JG); red wine (RW) and resveratrol solution (RG). The high-fat diet signifi cantly altered hepatocytes and Kupffer cells in all treated groups. HG group presented severe steatosis followed hepatocyte ballooning and tissue damages. JG group minimized hepatic histological lesion caused by high-fat diet and WG group also induced steatosis and infl ammation in hepatocytes, similar to HG. Still, resveratrol protected the tissue against fatty liver disease by reducing fat infi ltration and infl ammation, indicating possible therapeutic effects on the liver. Cell cycle analysis showed that HG promoted damage to the tissue, reducing the viable cell content and increasing apoptosis, even when associated with wine consumption or isolated resveratrol. However, JG protected the liver against cell damage generated by the diet. Consumption of grape juice, even associated with a high-fat diet, represents a promising protection of the liver against cellular damage, but red wine further affects the tissue, and resveratrol alone was able to reduce damage but did not minimize cellular damage to the liver.

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Prevalence of overweight/obesity and associated factors among basic education teachers in a city in the north of Minas Gerais, Brazil

et al. 2021

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Objective To estimate the prevalence of overweight/obesity and its associated factors among basic education teachers. Methods This is a cross-sectional study with probabilistic sampling by clustering. A questionnaire with socio-demographic, occupational, and psychosocial variables, as well as lifestyle, and health profiles was used. Results 707 teachers participated in the study. Associations with overweight / obesity were found for the variables: the male gender, age >40 years, three or more children, workload, contracted/designated employment relationship, fat intake through meat, abusive consumption of alcoholic beverages, presence of depressive episodes, endocrine problems, arterial hypertension, and negative self-perception of health with the prevalence ratio ranging from 1.16 to 1.52 in the associated variables. Conclusion Overweight / obesity affected approximately half of those surveyed. There is a relationship between sociodemographic, occupational, and psychosocial variables and lifestyles, on the one hand, and health factors and the presence of overweight / obesity in teachers, on the other. Measures must be implemented on modifiable factors, aiming to promote their quality of life.

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Polifenóis No Vinho: Resveratrol E Seus Benefícios

Cited by 3 publications

References 25 publications

"Therapeutic Uses of Resveratrol Compound in Chagas Disease - A Literature Review"

"Therapeutic Uses of Resveratrol Compound in Chagas Disease - A Literature Review"

Effects of grape juice, red wine and resveratrol on liver parameters of rat submitted high-fat diet

Prevalence of overweight/obesity and associated factors among basic education teachers in a city in the north of Minas Gerais, Brazil

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