2018
DOI: 10.20344/amp.9184
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Polimorfismos Genéticos Associados ao Aparecimento de Hipertensão Arterial Numa População Portuguesa

Abstract: Introduction: Arterial hypertension is a complex, multifactorial disease, controlled by genetic and environmental factors.Objective: Evaluate the genetic susceptibility for developing arterial hypertension and its association with the traditional risk factors in the outbreak of this pathology.Material and Methods: Case-control study with 1712 individuals, mean age of 51.0 ± 7.9 years (860 hypertensive patients and 852 controls). Biochemical and traditional risk factors, and genetic variants were evaluated: ACE… Show more

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Cited by 20 publications
(19 citation statements)
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“…I/D represents the insertion/deletion of a fragment of the ACE gene, which results in an increase in plasma ACE levels and activity. This genetic variation closely correlates with EHT (23, 24).…”
mentioning
confidence: 78%
See 1 more Smart Citation
“…I/D represents the insertion/deletion of a fragment of the ACE gene, which results in an increase in plasma ACE levels and activity. This genetic variation closely correlates with EHT (23, 24).…”
mentioning
confidence: 78%
“…It has been established that M235T-AGT and I/D-ACE gene variants play a role in the etiology of IHD and the development of MI in Caucasian and Japanese subjects (24,36,37). Ethnicity, geographical area, and environmental factors influence this association (21).…”
Section: Discussionmentioning
confidence: 99%
“…Рас пространенность данного полиморфизма среди европеоидной расы достаточно широка и составляет 27%. Исследования показали, что лица, страдающие АГ, достоверно чаще имели генотип А/С или С/С гена AGTR1 по сравнению со здоровыми людьми [38][39][40].…”
Section: клиническое значение полиморфизма A1166c A>с (Rs5186) гена рецептора 1 типа к ангиотензину-іі (Agtr1)unclassified
“…подтверждающих результатов получено не было [8][9][10][11][12][13]. В других же наблюдениях сообщалось о значимом влиянии I/D полиморфизма АСЕ на развитие заболевания, чаще у мужчин [14][15][16][17][18][19][20][21]. В популяционном Фрамингемском исследовании была выявлена взаимосвязь полиморфизма I/D гена АСЕ c АГ и повышенным уровнем диастолического АД (ДАД) у мужчин в отличие от женщин [22].…”
Section: Adherence To Ethical Standardsunclassified