Polimorfismos genéticos en la sepsis

Garnacho-Montero, José; Montero, Maisa; Leyba, C. Ortiz; Pallás, T. Aldabó

doi:10.1016/s0210-5691(05)74226-1

Cited by 5 publications

(2 citation statements)

References 15 publications

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“…As is witnessed by the recent decades, an explosion of research occurred to address the effect of genetic predisposition on the development and course of sepsis, and a single nucleotide polymorphism (SNP) in CD14 with a frequency higher than 1% in the population succeeded to draw global attention [6]. …”

Section: Introductionmentioning

confidence: 99%

Association between the -159C/T polymorphism in the promoter region of the CD14 gene and sepsis: a meta-analysis

Ren

et al. 2017

BMC Anesthesiol

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BackgroundThe association between CD14-159C/T polymorphism and sepsis has been assessed but results of current studies appeared conflicting and inconstant. This analysis was aimed to determine whether the CD14-159C/T polymorphism confers susceptibility to sepsis or is associated with increased risk of death from sepsis.MethodThe authors conducted a comprehensive search of PubMed, EMBASE, ISI Web of Science, Cochrane library, ScienceDirect, Wiley Online Library and CNKI databases according to a prespecified protocol. Language limits were restricted to English and Chinese. Two reviewers independently selected the articles and extracted relevant data onto standardized forms. Disagreements were settled by discussion and suggestions from senior consultants. The strength of association were evaluated by odds ratio (OR) and 95% confidence interval (CI). Studies failed to fit the Hardy-Weinberg-Equilibrium were excluded.ResultsThe research identified a total of 2317 full-text articles of which 14 articles met the predefined inclusion criteria. Meta-analysis was performed for allele frequency of C versus T, as well as genotypes CC + CT versus TT (dominant model), CC versus TT + CT (recessive model), CT versus TT and CC versus TT (additive model). All control samples were in Hardy-Weinberg proportion. No significant association between CD14-159C/T polymorphism and sepsis susceptibility or mortality were detected in the overall population. Nonetheless, subgroup analysis of Asian ethnicity revealed significant association between the CD14-159C/T polymorphism and susceptibility to sepsis in additive model (CC versus TT: OR = 0.52, 95% CI 0.29–0.92, p = 0.03) and recessive model (CC versus CT + TT: OR = 0.50, 95% CI 0.30–0.84, p = 0.009). Of note, three out of the five papers included in the subgroup focused exclusively on burn ICU patients.ConclusionsThis meta-analysis demonstrated that CD14-159C/T polymorphism is likely to be associated with susceptibility to sepsis in Asian population, especially for the TT genotype. However, bias may rise for etiologic reasons because the majority of subjects in the subgroup came from burn ICU. CD14-159C/T polymorphism is not relevant to sepsis mortality in any genetic models, regardless of the ethnicities. Due to the exploratory nature of the study, no adjustment for multiple testing was adopted, and therefore the results should be interpreted with precaution. Well-designed studies with larger sample size and more ethnic groups are required to further validate the results.Electronic supplementary materialThe online version of this article (doi:10.1186/s12871-017-0303-9) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%

Association between the -159C/T polymorphism in the promoter region of the CD14 gene and sepsis: a meta-analysis

Ren

et al. 2017

BMC Anesthesiol

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“…A limiting factor of this study is the sample number of 342 people which is small when it comes to analyzing polymorphisms, as a polymorphism is an allelic variation that appears in stable form in a population and must exhibit an incidence of at least 1%. 48 In addition, the sample may not have been sufficiently large to detect interactions among the variables. It is possible that, for more conclusive assertions about the genetic profile, one needs to consider a larger number of individuals and other variants of the miRNA-146a gene, which should be evaluated in combination through a study of the haplotype.…”

Section: Discussionmentioning

confidence: 99%

MicroRNA-146a polymorphism is not associated with cardiovascular disease in the elderly

et al. 2022

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Introduction: Cardiovascular diseases (CVD) figure among the most significant causes of morbidity and mortality in the world and, among genetic factors, the literature has demonstrated the crucial role of miRNAs and the relationship of physical activity with this pathology. Objective: To investigate the relationship between the functional capacity of exercise, the level of physical activity, and the polymorphism in the miRNA-146a gene in elderly individuals with and without CVD. Methods: This study, developed in a city in the southern region of Brazil, is characterized as cross-sectional. The sample for this study comprised 342 participants, aged 60 or over. The following aspects were analyzed: anthropometric characteristics, genetic profiles, diagnosis of CVD, functional capacity, and the level of physical activity. Results: A statistically significant association was observed between CVD and body mass index (BMI) (א² = 14.278; p = 0.0003), and 40.6% of elderly individuals with CVD were obese, while 31.5% of the normally developed elderly participants presented normal BMI. However, the genotype frequencies (p = 0.546; א² = 1.211) and 6MWT (p = 0.311; א² = 1.025) did not show a statistically signifi-cant association with CVD. Conclusion: Our results suggest that the polymorphism in the miRNA-146A (rs2910164) and functional capacity are not associated with CVD in the elderly. However, the BMI did demonstrate an association with this disease.

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Genetics and Sepsis

Alvarado¹

2023

The Sepsis Codex

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Polimorfismos genéticos en la sepsis

Cited by 5 publications

References 15 publications

Association between the -159C/T polymorphism in the promoter region of the CD14 gene and sepsis: a meta-analysis

Association between the -159C/T polymorphism in the promoter region of the CD14 gene and sepsis: a meta-analysis

MicroRNA-146a polymorphism is not associated with cardiovascular disease in the elderly

Genetics and Sepsis

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