Polivariant change of step-test under the influence of natural adaptogens and their accompaniments

et al. 2021

PPS

Self Cite

Background. Earlier, we found the multivariant nature of the Popovych's step test change in children after a course of adaptogenic balneotherapy. In particular, the step test improved in 53,7% of children, remained unchanged in 28,8%, and worsened in 17,5%. The purpose of this study is to identify predictors that allow us to forecast each variation of the step test. Material and methods. Object of observation was 80 children of both sexes, ages 10-17, arriving at the clinical sanatorium "Dzherelo" of Truskavets' spa from radionuclide contaminated territories. The main parameter of the study was the Popovych's step test. State of autonomous nervous, endocrine and immune systems was assessed as well as others functional and metabolic tests. Results. Discriminant analysis was subsequently applied to identify constellations of parameters-predictors of each variant of change in step test. The program selected 16 initial parameters as predictors (primarily level of step test, next sex, body mass and temperature, levels of Gench's and Teslenko's tests, vagal tone, erythrocytes sedimentation rate, trombocytes level as well as 7 immune parameters). The correctly of forecasting of the positive actotropic effect is 90,7%; of neutral is 78,3%; of negative is 92,9%, and total correctness is 87,5%. Conclusion. Balneotherapy causes multivariate changes in Popopvych's step test, which determined by constellation of 16 initial parameters.

Section: Discussionmentioning

confidence: 99%

“…The main subject of the study was the Popovych's step test [30,32,34]. State of autonomous nervous system was assessed by the method of HRV [1] using the "Cardio" device (Kyiv).…”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Forecasting of multivariant changes in Step test under the influence of natural adaptogens

Zukow

Flyunt

et al. 2021

PPS

Self Cite

“…There are age-and sexspecific norm values [37] that can be used to judge whether differences or changes are within the normal range or can be considered significant. In addition, cardiorespiratory fitness is considered an attribute of health in general and non-specific resistance in particular [2,9,12,15], and is also an important target of adaptogenic agents [21,27,30,[48][49][50].…”

Section: Introductionmentioning

confidence: 99%

Sexual dimorphism in the neuro-endocrine regulation of bicycle ergometric test parameters in untrained individuals with dysfunction of the neuro-endocrine-immune complex

Zakalyak

et al. 2022

J Educ Health Sport

Background. Ergometric physical working capacity (PWC) testing has a long tradition in occupational medicine. PWC can be tested, using performance indicators like VO2max or the mechanical power. However, the calculated by bicycle ergometry PWC in reality reflects the reaction of the autonomic nervous system to muscle load, which, in turn, is strong, but still not absolutely complete, correlates with VO2max as a real indicator of cardiorespiratory fitness. The purpose of this study is to clarify the relationship between PWC, calculated based on the result of two-stage bicycle ergometry, and the parameters of neuro-endocrine regulation as well as sexual differences in such relationships. Materials and Methods. The object of observation were 30 women 29-76 (49,4±11,0) years and 30 men 24-69 (47,4±12,0) years without a clinical diagnosis, but with the deviations from the norm in a number of parameters of the neuro-endocrine-immune complex as a manifestation of maladaptation. For estimation of PWC a two-stage bicycle ergometry used. Parameters of EEG, HRV and adaptation hormones levels registered twice with an interval of 4 or 7 days. Results. In men, PWC correlates negatively with plasma levels of cortisol (r=-0,52) and triiodothyronine (r=-0,47), but positively with levels of calcitonin (r=0,25) and testosterone (r=0,22). The coefficient of multiple correlation R=0,705. In women, the correlation of the twice lower PWC with cortisol and calcitonin is weaker (r=-0,31 and 0,18, respectively), and is absent with testosterone and triiodothyronine, instead it was found in relation to aldosterone (r=-0,24); R=0,394. The PWC regression model for men includes 6 HRV and 11 EEG parameters (R=0,846), while for women only the mode HRV (r=-0,56) and two EEG parameters (R=0,608). Conclusion. PWC levels in men are generally downregulated by cortisol, triiodothyronine, sympathetic tone, and θ-rhythm generating neurons, but upregulated by testosterone, calcitonin, vagal tone, and related α-rhythm generating neurons. In women, PWC levels are borderline downregulated by cortisol and aldosterone, but significantly upregulated by circulating catecholamines and β-rhythm generating neurons.

“…However, in contrast to the beneficial effect of the latter on stress resistance and the neuro-endocrine-immune complex, the effect on the physical performance of both rats and resort patients is ambiguous [46][47][48]56,57,60], which prompted the additional use of aerobic training [42,[46][47][48][50][51][52][53] and phytoadaptogens, both well-known (ginseng, Bittner's balsam), and the Ukrainian phytocomposition "Balm Kryms'kyi" [1,10,11,16,17,24], the adaptogenic properties of which first discovered by representatives of the Truskavetsian Scientific School of Balneology [1,28,31,33].…”

Section: Introductionmentioning

confidence: 99%

Phytoadaptogen reverses the adverse effects of Naftussya bioactive water on dynamic muscle performance in healthy rats

Zakalyak

2022

Background.. Muscular performance is considered one of the attributes of health and non-specific resistance. Phytoadaptogens occupy an important place in the arsenal of means of increasing non-specific resistance and stress resistance. Many years of research of the Truskavetsian Scientific School of Balneology have demonstrated the adaptogenic properties of the main therapeutic factor of the resort, Naftussya bioactive water, as well as ozokerite and mineral baths. However, in contrast to the beneficial effect of the latter on stress resistance and the neuro-endocrine-immune complex, the effect on the physical performance is ambiguous. The purpose of this study is to test the ability of phytocomposition to prevent the adverse actotropic effect of Naftussya bioactive water at rats. Material and methods. The experimentt have been carried out at 42 female rats. Rats of the control group for 7 days loaded through a tube with tap daily water (2 mL once), while the animals of the other groups received according to a similar scheme daily water with the addition of 0,1 mL of Balm; bioactive Naftussya water per se or with the addition of 0,1 mL of Balm. The day after completion the course of water loads in the animal determined the urinary excretion of 17-ketosteroids, assessed the mineralocorticoid activity (MCA) by the urine K/Na ratio as well as the state of neutrophil phagocytosis by the number of absorbed latex particles. Results. It was found that the weekly use of Naftyssya bioactive water reduces the duration of swimming of rats to exhaustion by 30% compared to the daily water control. Addition of phytoadaptogen to Naftyssya softens its negative actotropic effect by up to -9%, and adding Balsam to daily water prolongs the maximum duration of swimming compared to the control by 11%. A positive correlation of the swimming test with 17-KS excretion and water diuresis was revealed, but a negative correlation with MCA, spontaneous diuresis and neutrophils phagocytosis. Conclusion. Phytoadaptogen reverses the adverse effects of Naftussya bioactive water on dynamic muscle performance in healthy rats by mitigating the decrease in the excretion of 17-ketosteroids and increased mineralocorticoid activity.