Background. Previous experimental and clinical-physiological studies have shown that the Ukrainian phytocomposition “Balm Kryms’kyi” has adaptogenic properties, which are manifested in its vegetative, endocrine, immunotropic, coagulotropic, actotropic and metabolic effects. However, the neurotropic properties of the phytocomposition remain unclear, which is the purpose of this study. Materials and methods. The object of observation were 12 women (44±13 years) and 62 men (44±12 years) with dysfunction of neuro-endocrine-immune complex. HRV and EEG parameters were recorded in the morning in basal conditions. Then the members of the main group used 5 ml of phytocomposition dissolved in 45 ml of tap water, instead in the control group used 50 ml of the latter. After 1,5 hours, the test was repeated. Results. Discriminant analysis revealed 30 EEG parameters and 4 HRV parameters characteristic of the initial state and after consumption of phytocomposition or tap water. Conclusion. Ukrainian phytocomposition “Balm Truskavets” causes immediate neurotropic effects at patients with dysfunction of neuro-endocrine-immune complex.

Background. The immunoneuroendocrinology became the foundation of the Truskavetsian Scientific School of Balneology. The focus of research was on the relationships between EEG and HRV parameters, EEG&HRV and leukocytogram, phagocytosis, cellular and humoral immunity as well as between changes in these parameters under the influence of adaptogenic factors Truskavets’ spa. The purpose of this study is relationships between plasma levels of major adaptogene hormones and EEG&HRV parameters at human with dysadaptation. Materials and Methods. The object of observation were 10 women 33-76 y and 10 men 37-67 y without a clinical diagnosis, but with the deviations from the norm in a number of parameters of the neuro-endocrine-immune complex as a manifestation of dysadaptation. Parameters of EEG and HRV as well as hormones levels before and after a one-week course of drinking of Naftussya bioactive water registered. Results. Using the method of canonical correlation analysis, it was found that the level of triiodothyronine is determined by the constellation of 17 EEGs and 4 HRVs parameters by 87,5%. The rate of determination of the cortisol level by 14 EEGs and 3 HRVs parameters is 83,7%, and aldosterone by the other 14 EEGs and 3 HRVs parameters is 80,0%. Neuromodulation of testosterone and calcitonin levels is characterized by sexual dimorphism. With the same coefficients of determination (92,4%), the regression model for testosteroneemia in women included 15 EEGs parameters and no HRV parameters, instead testosteroneemia in men is modulated by other 11 EEGs parameters and one HRV parameter. The level of calcitonin in women is determined by 86,2% by the constellation of 9 EEGs and 2 HRVs parameters, while in men by 83,5% by the other 5 EEGs and 4 HRVs parameters. Conclusion. Plasma levels of the main adaptation hormones are accompanied by specific patterns of EEG and HRV parameters.

Background. Back in 2015, we registered short-term reactions to the Ukrainian phytocomposition of electroencephalogram and heart rate variability parameters. At the same time, we also recorded the reactions of biophotonics (GDV) parameters, but due to the skepticism of Ukrainian academic science regarding this method, we did not dare to include the results in the article. Materials and methods. The object of observation were 12 women (44±13 years) and 62 men (44±12 years) with dysfunction of neuro-endocrine-immune complex. GDV, HRV and EEG parameters were recorded in the morning in basal conditions. Then the members of the main group used 5 ml of phytocomposition dissolved in 45 ml of tap water, instead in the control group used 50 ml of the latter. After 1,5 hours, the test was repeated. Results. Discriminant analysis revealed 26 EEG, 6 HRV and 7 GDV parameters characteristic of the initial state and after consumption of phytocomposition or tap water. The use of balm causes the normalizing decrease of increased sympathotonic markers and the increase of decreased vagotonic markers. Physiologically favorable vegetotropic effects of the balm are accompanied by a further increase in the initially increased activity of β-rhythm-generating cortical and subcortical structures as well as activation of θ-rhythm-generating and inhibition of α- and δ-rhythm-generating nuclei whose initial activity was within normal limits. Neurotropic effects are accompanied by a decrease in fractality and entropy and an increase in the area of GDI, as well as the energy of the first, fourth, fifth and seventh chakras (virtual). Conclusion. Ukrainian phytocomposition “Balm Truskavets’” causes favorable immediate neurotropic and biophysic changes at patients with dysfunction of neuro-endocrine-immune complex.

Background. Ergometric physical working capacity (PWC) testing has a long tradition in occupational medicine. PWC can be tested, using performance indicators like VO2max or the mechanical power. However, the calculated by bicycle ergometry PWC in reality reflects the reaction of the autonomic nervous system to muscle load, which, in turn, is strong, but still not absolutely complete, correlates with VO2max as a real indicator of cardiorespiratory fitness. The purpose of this study is to clarify the relationship between PWC, calculated based on the result of two-stage bicycle ergometry, and the parameters of neuro-endocrine regulation as well as sexual differences in such relationships. Materials and Methods. The object of observation were 30 women 29-76 (49,4±11,0) years and 30 men 24-69 (47,4±12,0) years without a clinical diagnosis, but with the deviations from the norm in a number of parameters of the neuro-endocrine-immune complex as a manifestation of maladaptation. For estimation of PWC a two-stage bicycle ergometry used. Parameters of EEG, HRV and adaptation hormones levels registered twice with an interval of 4 or 7 days. Results. In men, PWC correlates negatively with plasma levels of cortisol (r=-0,52) and triiodothyronine (r=-0,47), but positively with levels of calcitonin (r=0,25) and testosterone (r=0,22). The coefficient of multiple correlation R=0,705. In women, the correlation of the twice lower PWC with cortisol and calcitonin is weaker (r=-0,31 and 0,18, respectively), and is absent with testosterone and triiodothyronine, instead it was found in relation to aldosterone (r=-0,24); R=0,394. The PWC regression model for men includes 6 HRV and 11 EEG parameters (R=0,846), while for women only the mode HRV (r=-0,56) and two EEG parameters (R=0,608). Conclusion. PWC levels in men are generally downregulated by cortisol, triiodothyronine, sympathetic tone, and θ-rhythm generating neurons, but upregulated by testosterone, calcitonin, vagal tone, and related α-rhythm generating neurons. In women, PWC levels are borderline downregulated by cortisol and aldosterone, but significantly upregulated by circulating catecholamines and β-rhythm generating neurons.

Background. Earlier, we found a close correlation between EEG and gas-discharge image (GDI) parameters. The aim of this study is to analyze the relationship of EEG parameters with the energy and asymmetry of virtual chakras, reconstructed on the basis of GDI parameters. Material and Methods. We observed twice 31 women and 29 men aged 26-76 years with dysfunction of neuroendocrine-immune complex. In the morning in basal conditions at first registered GDI by the method of GDV by the device “GDV Chamber” (“Biotechprogress”, SPb, RF). Than we registered EEG. Results processed by method of canonical analysis, using the software package “Statistica 64”. Results. The coefficients of canonical correlation between the EEG parameters and virtual Chakras Energy are in the interval 0,415÷0,564 and 0,358÷0,528 when registering without a filter and with a filter, respectively. Additional inclusion of HRV and endocrine parameters increases the strength of the canonical correlation to 0,768 and 0,772, respectively. The coefficients of canonical correlation between the EEG parameters and individual virtual Chakras Asymmetry are in the interval 0,284÷0,634 and 0,152÷0,458 when registering without a filter and with a filter, respectively. Integral coefficient of the canonical correlation is 0,820. Conclusion. The above data, taken together with the previous ones, state that between parameters of neuroendocrine-immune complex and GDV exist strong canonical correlation suggesting suitability of the latter method.