Poly [1,1'-bis(ethynyl)-4,4'-biphenyl(bis-tributylphosphine)Pt(II)] solutions used as low dose ionizing radiation dosimeter

Bronze‐Uhle, Erika S.; Batagin‐Neto, Augusto; Fernandes, David Moreira; Fratoddi, Ilaria; Russo, Maria Vittoria; Graeff, Carlos Frederico de Oliveira

doi:10.1063/1.4812186

Cited by 4 publications

(4 citation statements)

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“…Aer suitable functionalization, these particles can be engineered to accumulate preferentially at tumor sites, becoming a new agent in cancer treatment, and providing, moreover, a powerful tool for drug delivery systems or for sensing devices. [8][9][10][11][12][13] This has resulted in a broad array of studies in which gold nanoparticles have assumed a relevant importance in innovative ways to control the transport and subsequent release of drugs to specic tissues. These mechanisms are furthermore facilitated by the fact that the release can proceed via internal stimuli, such as pH, or via external stimuli, such as light or heat.…”

Section: Iole Venditti Work As Amentioning

confidence: 99%

Gold nanoparticles and gold nanoparticle-conjugates for delivery of therapeutic molecules. Progress and challenges

et al. 2014

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This article reviews the most recent literature data on the applications of gold nanoparticles and their various conjugates which make them suitable structures towards biomedical and clinical purposes, with an emphasis on their use as drug delivery vehicles for selective targeting of cancer cells. With the rapid surge in the development of nanomaterials, new methodologies and treatment strategies have been explored and these topics should be taken into consideration when a current scenario is required in the design of new experimental approaches or in a comprehensive data interpretation. We present here a summary of the main properties of gold nanoparticles and their conjugates and the state-of-the-art of non-conventional treatment in targeted drug delivery based on gold nanoparticles as carriers, with the aim to give the reader an overview of the most significant advances in this field

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Section: Iole Venditti Work As Amentioning

confidence: 99%

Gold nanoparticles and gold nanoparticle-conjugates for delivery of therapeutic molecules. Progress and challenges

et al. 2014

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“…Similar work was continued by Uhle et al on polymetallayne poly [1,1′‐bis (ethynyl)‐4,4′‐biphenyl (bis‐tributylphosphine) Pt(II)] (Pt‐DEBP) in chloroform solution. The ratio of the emission amplitude bands was proposed as the dosimetric parameter for the change of its optical properties upon radiation, which showed a linear dependency effect . Findings made by Uhle et al in both papers, however, conclude that γ‐radiation has induced polymer chain scission through the dissociation of the chlorine radicals from chloroform, which attack the polymer.…”

Section: Radiation Sensor Based On the Optical Properties Of Conjugatmentioning

confidence: 99%

Optical properties of conjugated polymer: review of its change mechanism for ionizing radiation sensor

Isa

Baharin

Majid

et al. 2017

Polymers for Advanced Techs

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A review on the change mechanism of conjugated polymer upon radiation exposure is presented. The change mechanism is mainly focused on the polymer's optical properties instead of its electrical properties. This research explores the effect of ionizing radiation on the optical change of conjugated polymer. This study also reviewed the possibility of using conjugated polymer as a radiation sensor vis‐à‐vis radiation type and the optical response. From material point of view, topochemical reaction, conjugation length and the degree of anisotropy of the conjugated polymer itself were identified as factors affecting the polymer's optical properties. These factors are tunable to meet a required optical degree, thus making the observation using the optical properties of a conjugated polymer possible for a radiation sensing tool. Based on the review, alteration of the factors and its mechanism of change occurs at macromolecular level. Therefore, a material at its smallest size down to a single molecule could be possible for the indication of radiation. Thus, radiation sensor made of nano or micro colloidal conjugated polymer deserves attention for future development. Copyright © 2017 John Wiley & Sons, Ltd.

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“…These scattered doses of magnitudes lower than 1 Gy can induce unintended secondary effects in patients . However, MEH‐PPV based dosimeters do not typically respond to doses lower than 1 Gy . Detection limits were improved by using an organometallic polymer 1,1′‐bis(ethynyl)‐4,4′‐biphenyl (DEBP) with a platinum metal center as a potential radiation dosimeter .…”

Section: Molecular Systemsmentioning

confidence: 99%

“…The presence of a transition metal (Pt) renders unique structural, optical and electronic properties to the polymer. An important feature is the presence of a delocalized π‐conjugated electron cloud which extends and reaches the metal center from the polymeric backbone . Chlorine incorporation reduces the spin density on Pt, thereby increasing the output fluorescence signal.…”

Section: Molecular Systemsmentioning

confidence: 99%

Molecular and Nanoscale Sensors for Detecting Ionizing Radiation in Radiotherapy

2016

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Ever since the discovery of radioactivity,b eneficial use of ionizing radiation has been pursued for the betterment of human health. In particular, fractionated radiotherapy is commonlyu sed in the clinic fora blation of malignant tumors. Use of higher radiation dose fractionsa nd complex dose trajectories necessitate measurements of radiation dose delivered to the target tissue and surrounding tissues in order to ensure patient safety.T raditional dosimeters including polymer gel dosimeters, radiochromic films and metal-oxide semiconductor field effect transistors (MOSFETs) suffer from limitations, whichc omplicate their day-to-day use in the clinic. Molecular and nanoscale systems offer great potentialf or the development of effective sensors of ionizingr adiation,w hich can lead to quantitative dosimeters in biological settings. Thisr eview discusses recent developments based on organic and inorganic molecular and nanoscale dosimeters including quantum dots,p olymers and plasmonic nanoparticles as platforms for radiation sensing. Potential advantages and challenges of translating these technologiestoc linical applicationsare also discussed.

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Poly [1,1'-bis(ethynyl)-4,4'-biphenyl(bis-tributylphosphine)Pt(II)] solutions used as low dose ionizing radiation dosimeter

Cited by 4 publications

References 28 publications

Gold nanoparticles and gold nanoparticle-conjugates for delivery of therapeutic molecules. Progress and challenges

Gold nanoparticles and gold nanoparticle-conjugates for delivery of therapeutic molecules. Progress and challenges

Optical properties of conjugated polymer: review of its change mechanism for ionizing radiation sensor

Molecular and Nanoscale Sensors for Detecting Ionizing Radiation in Radiotherapy

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