Poly(3-hydroxyoctanoate) containing pendant carboxylic groups for the preparation of nanoparticles aimed at drug transport and release

Kurth, N; Renard, Estelle; Brachet, Franck; Robic, Daniel; Guérin, Ph.; Bourbouze, Richard

doi:10.1016/s0032-3861(01)00692-9

Cited by 77 publications

(62 citation statements)

References 19 publications

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“…The unsaturated side chains containing double bonds offer potentials for functionalizing these mcl-PHAs with improved properties or extended applications through chemical modification, such as chlorination, 126,127 crosslinking, [128][129][130][131] carboxylation, 131,132 hydroxylation, 133,134 and epoxidation. [135][136][137][138][139][140][141] Such modifications for the pedant groups make these mcl-PHAs functional with unusual physicochemical and mechanical properties.…”

Section: Biosynthesis and Modification Of Mcl-phas From Glycerolmentioning

confidence: 99%

Bioplastics from waste glycerol derived from biodiesel industry

Zhu

Chiu

Nakas

et al. 2013

J of Applied Polymer Sci

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Polyhydroxyalkanoates (PHAs) are polyesters that can be biologically synthesized by many microorganisms and engineered plants that have been investigated by microbiologists, biochemists, polymer scientists, material engineers, and medical researchers for several decades. Research on microbial production of PHAs has been extensively focused on using pure carbon sources, such as sugars and fatty acids. Practical considerations of production costs of PHAs have resulted in research efforts to use alternative renewable and inexpensive feedstocks. One potential feedstock for the production of PHA polymers is the glycerol waste byproduct of biodiesel production. The major focus of this review is the production of PHA polymers from glycerol. A review of biosynthetic pathways for PHAs production from glycerol, current production of waste glycerol in biodiesel industry, physical and mechanical properties of PHAs, and applications of PHAs in the areas of packaging industry, implant materials, drug carrier, biofuels, are covered.

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Section: Biosynthesis and Modification Of Mcl-phas From Glycerolmentioning

confidence: 99%

Bioplastics from waste glycerol derived from biodiesel industry

Zhu

Chiu

Nakas

et al. 2013

J of Applied Polymer Sci

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“…Various mclPHAs with side chains containing functional groups, for example carboncarbon double (Lageveen et al, 1988) and triple bonds (Kim et al, 1998), acetoxy and ketone (Jung et al, 2000), or aromatic groups (Curley et al, 1996;Fritzsche et al, 1990;Kim et al, 1999) have been produced. The presence of unsaturated side chains provides sites for chemical modifications like crosslinking (de Koning et al, 1994;Dufresne et al, 2001;Hazer et al, 2001), epoxidation (Bear et al, 1997), conversion to carboxylic (Kurth et al, 2002;Stigers and Tew, 2003), and diol groups (Lee et al, 2000), or the synthesis of crystalline comb polymers . In this study, we investigated the production of olefinic mclPHAs from mixtures of octanoic acid and 10-undecenoic acid in batch and dual (C,N) nutrient limited chemostat cultures.…”

Section: Introductionmentioning

confidence: 99%

Tailor-made olefinic medium-chain-length poly[(R)-3-hydroxyalkanoates] byPseudomonas putida GPo1: Batch versus chemostat production

Hartmann

Hany

Pletscher

et al. 2006

Biotechnol. Bioeng.

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Functionalized medium-chain-length polyhydroxyalkanoates (mclPHAs) have gained much interest in research on biopolymers because of their ease of chemical modification. Tailored olefinic mclPHA production from mixtures of octanoic acid and 10-undecenoic acid was investigated in batch and dual (C,N) nutrient limited chemostat cultures of Pseudomonas putida GPo1 (ATCC 29347). In a batch culture, where P. putida GPo1 was grown on a mixture of octanoic acid (58 mol%) and 10-undecenoic acid (42 mol%), it was found that the fraction of aliphatic monomers was slightly lower in mclPHA produced during exponential growth than during late stationary phase. Thus, the total monomeric composition changed over time indicating different kinetics for the two carbon substrates. Chemostat experiments showed that the dual (C,N) nutrient limited growth regime (DNLGR) for 10-undecenoic acid coincided with the one for octanoic acid. Five different chemostats on equimolar mixtures of octanoic acid and 10-undecenoic acid within the DNLGR revealed that the monomeric composition of mclPHA was not a function of the carbon to nitrogen (C(0)/N(0)) ratio in the feed medium but rather of the dilution rate. The fraction of aliphatic monomers in the accumulated mclPHA was slightly lower at high dilution rates and increased towards low dilution rates, again indicating different kinetics for the two carbon substrates in P. putida GPo1.

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“…Novel chemical, chemoenzymatic, and biological routes have been established, leading to an extended family of poly(β-hydroxyacids). Thus, in addition to bacterial polyesters, new polymers obtained by copolymerization and chemical modification of poly(β-malic acid) (PMLA) were prepared (Figure 1) [55][56][57][58]. The poly(β-malic acid) has been the subject of several research themes for various temporary therapeutic applications thanks to its good properties.…”

Section: Historymentioning

confidence: 99%