Poly(Acrylic Acid)–Poly(Ethylene Glycol) Nanoparticles Designed for Ophthalmic Drug Delivery

Vasi, Ana-Maria; Popa, Marcel; Tanase, Constantin Edi; Butnaru, Maria; Vereştiuc, Liliana

doi:10.1002/jps.23793

Cited by 23 publications

(28 citation statements)

References 39 publications

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“…The supernatant was separated by centrifugation (13.400 rpm; 12.927 RCF; 20 min) and measured by UV-Vis using a Perkin Elmer Lambda 35 spectrophotometer at 554 nm. The drug entrapment efficiency ( ) was calculated from a calibration curve of RhB using the following equation (Vasi et al, 2014):…”

Section: Rhb Loading and Release Studiesmentioning

confidence: 99%

Carboxymethyl guar gum nanoparticles for drug delivery applications: Preparation and preliminary in-vitro investigations

Dodi

Pala

Barbu

et al. 2016

Materials Science and Engineering: C

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Carboxymethyl guar gum (CMGG) synthesized from commercially available polysaccharide was formulated into nanoparticles via ionic gelation using trisodium trimetaphosphate (STMP) as cross-linking agent. Characterisation using a range of analytical techniques (FTIR, NMR, GPC, TGA and DLS) confirmed the CMGG structure and revealed the effect of the CMGG and STMP concentration on the main characteristics of the obtained nanoformulations. The average nanoparticle diameter was found to be around 208 nm, as determined by dynamic light scattering (DLS) and confirmed by scanning electron microscopy (SEM) and nanoparticle tracking analysis (NTA). Experiments using simulated gastric and intestinal fluids evidenced significant pH-dependent drug release behaviour of the nanoformulations loaded with Rhodamine B (RhB) as a model drug (loading capacity in excess of 83%), as monitored by UV-Vis. While dose-dependent cytotoxicity was observed, the nanoformulations appeared completely non-toxic at concentrations below 0.3 mg/mL. Results obtained so far suggest that carboxymethylated guar gum nanoparticles formulated with STMP warrant further investigations as polysaccharide based biocompatible drug nanocarriers.

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Section: Rhb Loading and Release Studiesmentioning

confidence: 99%

Carboxymethyl guar gum nanoparticles for drug delivery applications: Preparation and preliminary in-vitro investigations

Dodi

Pala

Barbu

et al. 2016

Materials Science and Engineering: C

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“…To measure the swelling ratio, the dried film was prepared by an 8 mm biopsy punch The MD/PAAc sample was prepared by using a 12 mm biopsy punch and then subjected to 18 compressive strength measurements using a texture analyzer (TA-XT2i, Stable Micro Systems…”

Section: Determination Of Swelling Ratio 10mentioning

confidence: 99%

“…In the case of radiation-induced cross-linking, cross links are formed at the carbon atom of 17 the C-C bond in the polyvinyl polymer, because one or more hydrogen atoms could be attached 18 to the carbon atom. The radiation cross-linking method has many advantages: cross-linking 19 agents are not required [9,10]; no residual toxic substances are found in the hydrogel; 20 hydrogels having diverse properties can be fabricated by simply controlling radiation dose,…”

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confidence: 99%

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Development and Characterization of Cross-Linked Poly(acrylic acid) Hydrogel Containing Drug by Radiation-Based Techniques

Jeong¹,

Baik²,

An³

et al. 2018

Preprint

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“…PAA hydrogels have been widely used as drug carriers because of their good bioadhesive properties and enhanced drug penetration. It is possible to localize the absorption site of a drug in the PAA hydrogel and to increase the drug residence time [27].…”

Section: Introductionmentioning

confidence: 99%

Preparation of Radiation Cross-Linked Poly(Acrylic Acid) Hydrogel Containing Metronidazole with Enhanced Antibacterial Activity

Jeong

Park

Kim

et al. 2019

IJMS

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Metronidazole (MD) is known as a periodontitis medicine and has been widely used in antibiotics for resistance to anaerobic bacteria, periodontal disease, and other threats. To treat diseases, drug delivery carriers are needed with a high bioadhesive property and enhanced drug penetration. Poly (acrylic acid) (PAA) hydrogel films have a good bioadhesive property and are able to localize the absorption site and increase the drug residence time. In this study, we fabricated a MD loaded PAA hydrogel with different MD content (0.1, 0.25, 0.5, and 1 wt%) using varying doses (25, 50, and 75 kGy) and the radiation doses (25, 50, or 75 kGy) in a one-step gamma-ray irradiation process. The chemical and physical structure were determined through a Fourier transformed infrared spectroscopy, X-ray photoelectron spectroscopy, gel content, and compressive strength. In addition, MD loaded PAA hydrogels were performed to MD release behaviors and cytotoxicity. Finally, we conducted antibacterial activity to demonstrate the prevention of growth of bacteria as a therapeutic dressing. The basic chemical structure analysis of MD was changed greatly at radiation doses of 50 and 75 kGy due to degradation by gamma-ray irradiation. However, when the absorbed dose was 25 kGy, the chemical structure analysis of MD did not change significantly, and the gel content and compressive strength of MD/PAA hydrogel were approximately 80% and 130 kPa, respectively. The MD/PAA hydrogels exhibited no cytotoxicity and good antibacterial activity against Escherichia coli, Staphylococcus aureus, and Streptococcus mutans. These results provide good evidence that MD/PAA hydrogel prepared by gamma-ray irradiation has potential as a competitive candidate for the therapeutic dressing.

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Poly(Acrylic Acid)–Poly(Ethylene Glycol) Nanoparticles Designed for Ophthalmic Drug Delivery

Cited by 23 publications

References 39 publications

Carboxymethyl guar gum nanoparticles for drug delivery applications: Preparation and preliminary in-vitro investigations

Carboxymethyl guar gum nanoparticles for drug delivery applications: Preparation and preliminary in-vitro investigations

Development and Characterization of Cross-Linked Poly(acrylic acid) Hydrogel Containing Drug by Radiation-Based Techniques

Preparation of Radiation Cross-Linked Poly(Acrylic Acid) Hydrogel Containing Metronidazole with Enhanced Antibacterial Activity

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