Poly(amidoamine), polypropylenimine, and related dendrimers and dendrons possessing different 1→2 branching motifs: An overview of the divergent procedures

Newkome, George R.; Shreiner, Carol D.

doi:10.1016/j.polymer.2007.10.021

Cited by 363 publications

(220 citation statements)

References 1,960 publications

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“…Uniform Au NPs with 2-4-nm diameters are obtainable by the loading of HAuCl 4 in the PAMAM dendrimers of various generations and by subsequent reduction with an appropriate reducing agent such as NaBH 4 . 84 Considering their applications to bionanomaterials, PEG-modified PAMAM dendrimers have been used for complex formation with Au NPs.…”

Section: Dendrimer-gold Np Hybridsmentioning

confidence: 99%

“…[1][2][3][4] Such a highly branched backbone gives dendrimers a globular shape that provides both a surface with certain properties and an interior that is capable of encapsulating guest materials. Furthermore, because molecular chains of dendrimers are grown stepwise by repeatedly introducing branch structures to their chain ends, their molecular size and structure can be controlled precisely.…”

Section: Introductionmentioning

confidence: 99%

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Dendrimer-based bionanomaterials produced by surface modification, assembly and hybrid formation

Kono

2012

Polym J

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Because of their highly defined chemical structure and globular shape, dendrimers are very attractive as base materials to be used in the production of nanomaterials for applications in various fields. Therefore, many attempts have been made to develop functional materials using dendrimers. This review specifically examines dendrimer-based nanomaterials intended for application to the biomedical field. The design, preparation and function of bionanomaterials, using various strategies such as surface modification, assembly and hybrid formation, are described briefly along with their potential applications.

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Section: Dendrimer-gold Np Hybridsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Dendrimer-based bionanomaterials produced by surface modification, assembly and hybrid formation

Kono

2012

Polym J

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“…Computational chemistry is a powerful tool to design, model, simulate, and visualize nanomaterials (Gao, 2001) and nanoparticles, such as dendrimers (Belting and Wittrup, 2009;Diekmann and Lindhorst, 2002;Newkome and Shreiner, 2007;Selim and Lee, 2009) Computer-assisted nanomolecule design has emerged from recent advances in computational chemistry and nanotechnology and is considered well suited for assisting the experimental community in the design of new nanostructures (Bewick et al, 2009). The major advantage of computational nano-design is that it provides a relatively inexpensive and rapid way to explore many structural designs, including the study of stability and prediction of properties (Shapiro et al, 2008).…”

Section: New Challenges For Bioinformatics and Computational Chemistrmentioning

confidence: 99%

Nanoinformatics: an emerging area of information technology at the intersection of bioinformatics, computational chemistry and nanobiotechnology

et al. 2011

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After the progress made during the genomics era, bioinformatics was tasked with supporting the fl ow of information generated by nanobiotechnology efforts. This challenge requires adapting classical bioinformatic and computational chemistry tools to store, standardize, analyze, and visualize nanobiotechnological information. Thus, old and new bioinformatic and computational chemistry tools have been merged into a new sub-discipline: nanoinformatics. This review takes a second look at the development of this new and exciting area as seen from the perspective of the evolution of nanobiotechnology applied to the life sciences. The knowledge obtained at the nano-scale level implies answers to new questions and the development of new concepts in different fi elds. The rapid convergence of technologies around nanobiotechnologies has spun off collaborative networks and web platforms created for sharing and discussing the knowledge generated in nanobiotechnology. The implementation of new database schemes suitable for storage, processing and integrating physical, chemical, and biological properties of nanoparticles will be a key element in achieving the promises in this convergent fi eld. In this work, we will review some applications of nanobiotechnology to life sciences in generating new requirements for diverse scientifi c fi elds, such as bioinformatics and computational chemistry.

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“…dendrons | ethylenediamine core | piperazine core | antimicrobials | nanomedicine A liphatic polyamide (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14) and peptide (15) dendrimers are complex monodisperse, functional compounds (16) synthesized by iterative divergent (1), convergent (17), and double-stage convergent-divergent (18) methods. Their nanoarchitecture emerges by increasing their generation number from ellipsoidal or disk-like 2D to 3D globular constructs (16,(19)(20)(21)(22)(23)(24)(25).…”

mentioning

confidence: 99%

Self-interrupted synthesis of sterically hindered aliphatic polyamide dendrimers

Jishkariani

MacDermaid

Timsina

et al. 2017

Proc. Natl. Acad. Sci. U.S.A.

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reviewed by Ezequiel Perez-Inestrosa and Donald A. Tomalia) 2,2-Bis(azidomethyl)propionic acid was prepared in four steps and 85% yield from the commercially available 2,2-bis(hydroxymethyl) propionic acid and used as the starting building block for the divergent, convergent, and double-stage convergent-divergent iterative methods for the synthesis of dendrimers and dendrons containing ethylenediamine (EDA), piperazine (PPZ), and methyl 2,2-bis(aminomethyl)propionate (COOMe) cores. These cores have the same multiplicity but different conformations. A diversity of synthetic methods were used for the synthesis of dendrimers and dendrons. Regardless of the method used, a self-interruption of the synthesis was observed at generation 4 for the dendrimer with an EDA core and at generation 5 for the one with a PPZ core, whereas for the COOMe core, self-interruption was observed at generation 6 dendron, which is equivalent to generation 5 dendrimer. Molecular modeling and molecular-dynamics simulations demonstrated that the observed self-interruption is determined by the backfolding of the azide groups at the periphery of the dendrimer. The latter conformation inhibits completely the heterogeneous hydrogenation of the azide groups catalyzed by 10% Pd/carbon as well as homogeneous hydrogenation by the Staudinger method. These self-terminated polyamide dendrimers are enzymatically and hydrolytically stable and also exhibit antimicrobial activity. Thus, these nanoscale constructs open avenues for biomedical applications.dendrons | ethylenediamine core | piperazine core | antimicrobials | nanomedicine

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Poly(amidoamine), polypropylenimine, and related dendrimers and dendrons possessing different 1→2 branching motifs: An overview of the divergent procedures

Cited by 363 publications

References 1,960 publications

Dendrimer-based bionanomaterials produced by surface modification, assembly and hybrid formation

Dendrimer-based bionanomaterials produced by surface modification, assembly and hybrid formation

Nanoinformatics: an emerging area of information technology at the intersection of bioinformatics, computational chemistry and nanobiotechnology

Self-interrupted synthesis of sterically hindered aliphatic polyamide dendrimers

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