Poly(butylene adipate-co-terephthalate) scaffolds: processing, structural characteristics and cellular responses

Abstract

The aliphatic-aromatic copolyester, poly(butylene adipate-co-terephthalate) (PBAT) combines good mechanical and thermal properties with biodegradation ability. However, until now, researches in its potential medical use remain limited. Only in a few studies blends of PBAT with routinely used biocompatible polymers had been prepared and investigated regarding tissue engineering applications. Therefore, in this study, we decided to determine processability of neat PBAT as a scaffold material for bone tissue by using different fabrication methods i.e. solvent evaporation, electrospinning, solvent casting-particulate leaching (SCPL) and melt molding-particulate leaching. The results of physicochemical characterizations and cell culture studies with MC3T3-E1 preosteoblasts confirmed that neat PBAT has favorable characteristics for bone tissue engineering, however, fabrication method strongly affects the cellular responses. Regarding to the characterizations and cell cultures, PBAT scaffolds produced by SCPL and electrospinning are proposed to be used for bone tissue engineering.

Enhanced osteogenic activity with boron-doped nanohydroxyapatite-loaded poly(butylene adipate-co-terephthalate) fibrous 3D matrix

“…Two-dimensional PBAT matrices were also fabricated by traditional electrospinning for comparison based on our previous study [25]. PBAT was first dissolved in HFIP at a concentration of 24% (w/v) and transferred into a syringe with a 21-gauge needle.…”

“…Characteristics of PBAT, HAp-PBAT and B-HAp-PBAT fibrous matrices are given in Table 2. In order to make a comparison between 2 D and 3 D fibrous matrices, characteristics of 2 D PBAT fibrous matrices fabricated in our previous study [25] are also presented in Table 2. As seen from this table, porosity of the 2 D fibrous matrices is $86% whereas that of 3 D fibrous matrices is $91%.…”

“…Recently, we have fabricated PBAT scaffolds by using conventional scaffold fabrication methods such as electrospinning, solvent casting-particulate leaching and melt moulding-particulate leaching [25]. Due to the highly porous nature, wettability properties and ECM similarity, 2 D electrospun PBAT matrices supported viability and proliferation of MC3T3-E1 cells.…”

Thrombin‐Loaded Poly(butylene succinate)‐Based Electrospun Membranes for Rapid Hemostatic Application

“…The water contact angles of PLA and PCL electrospun membranes prepared in this work are also very different from those of the corresponding nonporous films obtained by hot‐pressing (111.8° vs 84.2° and 135.7° vs 67.3°). It has also been reported that the water uptake capacity of a material is closely related to its porosity and increases when the porosity increases …”

Polypyrrole increases branching and neurite extension by Neuro2A cells on PBAT ultrathin fibers

“…PBAT is biodegradable by microorganisms and has an adjustable balance between optimal biodegradation and desirable physical-chemicalproperties (15). Thus, the use of PBAT, alone or in composite form, represents a great promise for the tissue engineering, since it presents desirable degradation rate, good thermal and mechanical properties and easy processability (16).…”