Poly(caprolactone-co-trimethylenecarbonate) urethane acrylate resins for digital light processing of bioresorbable tissue engineering implants

Kuhnt, Tobias; García, Ramiro Marroquín; Camarero‐Espinosa, Sandra; Dias, Aylvin A.; Cate, A. Tessa ten; Blitterswijk, Clemens A. van; Moroni, Lorenzo; Baker, Matthew B.

doi:10.1039/c9bm01042d

Cited by 35 publications

(40 citation statements)

References 33 publications

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“…Owing to the amorphous nature of the attached random copolymer chains, both polymers were liquid at room temperature, with Tg of -33.7 °C and -26.5 °C, respectively (Figure 1a). This is consistent with previous reports [51][52] and our recent work [53] on random copolymers. The light absorption of the BAPO polymers was measured in THF (0.1 mM) and compared to the commercial BAPO photoinitiator (Omnicure 819, with previous trade name Irgacure 819).…”

supporting

confidence: 94%

Solvent-Free Digital Light 3D Printing using Biodegradable Polymeric Photoinitiators

sandmeier¹,

paunovic²,

Conti³

et al. 2020

Preprint

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Vat photopolymerization 3D printing provides newopportunities for the fabrication of tissue scaffolds and medicaldevices. However, it usually requires the use of organic solvents ordiluents to dissolve the solid photoinitators, making this processenvironmentally unfriendly, and not optimal for biomedicalapplications. Here, we report biodegradable liquid polymericphotoinitiators for solvent-free 3D printing of biodegradable polymericmaterials by digital light processing. These photoinitiators enablesystematic investigation of structure-property relationship of 3Dprinting polymeric materials without the interference from the reactivediluents and offer new perspectives for the solvent-free 3D additivemanufacturing of bioresorbable medical implants as well as otherfunctional devices.

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supporting

confidence: 94%

Solvent-Free Digital Light 3D Printing using Biodegradable Polymeric Photoinitiators

sandmeier¹,

paunovic²,

Conti³

et al. 2020

Preprint

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show abstract

“…Notably, few hydrogels are widely bioprintable, thus hydrogel ink and bioink formulations are becoming extremely active areas of research. 114 Within hydrogels, novel cross-linking strategies and materials formulations including supramolecular ( Figure 4 c and 4 d), 105 , 112 , 120 dynamic covalent ( Figure 4 a and 4 b), 103 , 111 jammed microgels, 52 and gel-in-gel 51 have emerged as promising areas of research, often imparting improved printabilty and dynamic responsiveness of the gels ( Figure 4 ). DLP printing suffers from a lack of biodegradable and biocompatible resins for bioprinting; this gap is starting to be addressed by several research groups 115 , 116 and promises to be an active area of research in the near future.…”

Section: Biomaterials Biomaterials Inks and Bioinksmentioning

confidence: 99%

Bioprinting: From Tissue and Organ Development to in Vitro Models

et al. 2020

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Bioprinting techniques have been flourishing in the field of biofabrication with pronounced and exponential developments in the past years. Novel biomaterial inks used for the formation of bioinks have been developed, allowing the manufacturing of in vitro models and implants tested preclinically with a certain degree of success. Furthermore, incredible advances in cell biology, namely, in pluripotent stem cells, have also contributed to the latest milestones where more relevant tissues or organ-like constructs with a certain degree of functionality can already be obtained. These incredible strides have been possible with a multitude of multidisciplinary teams around the world, working to make bioprinted tissues and organs more relevant and functional. Yet, there is still a long way to go until these biofabricated constructs will be able to reach the clinics. In this review, we summarize the main bioprinting activities linking them to tissue and organ development and physiology. Most bioprinting approaches focus on mimicking fully matured tissues. Future bioprinting strategies might pursue earlier developmental stages of tissues and organs. The continuous convergence of the experts in the fields of material sciences, cell biology, engineering, and many other disciplines will gradually allow us to overcome the barriers identified on the demanding path toward manufacturing and adoption of tissue and organ replacements.

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“…Kuhnt et al. [ 72 ] synthesized PCL/PTMC copolymers with different monomer ratios using tri(ethylene glycol) (TEG) as an initiator. The resulting copolymers were functionalized with urethane acrylates and applied in DLP to fabricate films, which were subjected to accelerated degradation studies under alkaline conditions during 30 days.…”

Section: (Bio)degradable Photopolymersmentioning

confidence: 99%

Sustainable Photopolymers in 3D Printing: A Review on Biobased, Biodegradable, and Recyclable Alternatives

Voet

Guit

Loos

2020

Macromol. Rapid Commun.

165

131

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The global market for 3D printing materials has grown exponentially in the last decade. Today, photopolymers claim almost half of the material sales worldwide. The lack of sustainable resins, applicable in vat photopolymerization that can compete with commercial materials, however, limits the widespread adoption of this technology. The development of “green” alternatives is of great importance in order to reduce the environmental impact of additive manufacturing. This paper reviews the recent evolutions in the field of sustainable photopolymers for 3D printing. It highlights the synthesis and application of biobased resin components, such as photocurable monomers and oligomers, as well as reinforcing agents derived from natural resources. In addition, the design of biologically degradable and recyclable thermoset products in vat photopolymerization is discussed. Together, those strategies will promote the accurate and waste‐free production of a new generation of 3D materials for a sustainable plastics economy in the near future.

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Poly(caprolactone-co-trimethylenecarbonate) urethane acrylate resins for digital light processing of bioresorbable tissue engineering implants

Abstract: Biodegradable polyester urethane acrylate oligomers were created to address the scarcity of resins for Digital Light Processing (DLP). Cell adhesion was heavily influenced by copolymer composition.

Cited by 35 publications

References 33 publications

Solvent-Free Digital Light 3D Printing using Biodegradable Polymeric Photoinitiators

Solvent-Free Digital Light 3D Printing using Biodegradable Polymeric Photoinitiators

Bioprinting: From Tissue and Organ Development to in Vitro Models

Sustainable Photopolymers in 3D Printing: A Review on Biobased, Biodegradable, and Recyclable Alternatives

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