“…This finding indicates that the PLGA/Ti 3 C 2 hybrid coating would have a larger hole due to the free volume expansion of PLGA when the temperature exceeded 48.5 °C [ 44 ]. Moreover, the increase in intermolecular gap weakened the anti-electrolyte permeability property of the coating [ 47 ]. Fig.…”
Section: Resultsmentioning
confidence: 99%
“…With the NIR laser irradiation at 808 nm, the temperature of the hybrid coating exceeded the T g of PLGA. At this point, the increased movement of the polymer chains increased the free volume expansion of the PLGA/Ti 3 C 2 coating [ 47 ]. This phenomenon loosened the stacked Ti 3 C 2 nanosheets in the PLGA, and it increased the permeability of the coating to electrolytes.…”
A PLGA/Ti
3
C
2
hybrid coating was successfully deposited on the surface of magnesium-strontium (Mg-Sr) alloys. Compared with the corrosion current density (
i
corr
) of the Mg-Sr alloy (7.13 × 10
−5
A/cm
2
), the modified samples (Mg/PLGA/Ti
3
C
2
) was lower by approximately four orders of magnitude (7.65 × 10
−9
A/cm
2
). After near infrared 808 nm laser irradiation, the
i
corr
of the modified samples increased to 3.48 × 10
−7
A/cm
2
. The mechanism is that the local hyperthermia induced the free volume expansion of PLGA, and the increase in intermolecular gap enhanced the penetration of electrolytes. Meanwhile, the cytotoxicity study showed that the hybrid coating endowed the Mg-Sr alloy with enhanced biocompatibility.
“…This finding indicates that the PLGA/Ti 3 C 2 hybrid coating would have a larger hole due to the free volume expansion of PLGA when the temperature exceeded 48.5 °C [ 44 ]. Moreover, the increase in intermolecular gap weakened the anti-electrolyte permeability property of the coating [ 47 ]. Fig.…”
Section: Resultsmentioning
confidence: 99%
“…With the NIR laser irradiation at 808 nm, the temperature of the hybrid coating exceeded the T g of PLGA. At this point, the increased movement of the polymer chains increased the free volume expansion of the PLGA/Ti 3 C 2 coating [ 47 ]. This phenomenon loosened the stacked Ti 3 C 2 nanosheets in the PLGA, and it increased the permeability of the coating to electrolytes.…”
A PLGA/Ti
3
C
2
hybrid coating was successfully deposited on the surface of magnesium-strontium (Mg-Sr) alloys. Compared with the corrosion current density (
i
corr
) of the Mg-Sr alloy (7.13 × 10
−5
A/cm
2
), the modified samples (Mg/PLGA/Ti
3
C
2
) was lower by approximately four orders of magnitude (7.65 × 10
−9
A/cm
2
). After near infrared 808 nm laser irradiation, the
i
corr
of the modified samples increased to 3.48 × 10
−7
A/cm
2
. The mechanism is that the local hyperthermia induced the free volume expansion of PLGA, and the increase in intermolecular gap enhanced the penetration of electrolytes. Meanwhile, the cytotoxicity study showed that the hybrid coating endowed the Mg-Sr alloy with enhanced biocompatibility.
“…In a similar way, we determined the amount of loaded ICG from the UV-Vis absorbance at 780 nm using a calibration curve obtained from a series of ICG solutions in TFE. The amount of encapsulated FITC-BSA was indirectly derived from that of the not encapsulated portion, which was determined by centrifuging the hollow NPs after the encapsulation process and collecting 1 mL of the colloid-free solution, as reported in a previous literature [22].…”
A new system for the easy loading and NIR light-triggered release of drugs is introduced. It consists of poly(ε-caprolactone) (PCL) hollow nanoparticles with surface openings containing a biodegradable fatty acid with phase-change ability and a biocompatible photothermal agent. These openings, which can enhance the connectivity between the interior and the exterior, enable the easy loading of drug molecules into the interior voids, and their successive sealing ensures a stable encapsulation of the drug. Upon exposure to an external NIR light irradiation, the photothermal agent generates heat that raises the local temperature of the hollow particles above the melting point of the fatty acid, leading to the formation of nanopores on their shells, and consequently, the instant release of the encapsulated drug molecules through the pores. The synergistic activity of the hyperthermia effect from the photothermal agent and the NIR-triggered release of the drug molecules results in noticeable anticancer efficacy.
Streszczenie: Nanowłókna polimerowe wzbudzają obecnie ogromne zainteresowanie ze względu na ich potencjalne wykorzystanie w różnych procesach technologicznych, np. w produkcji tkanin lub wy twarzaniu membran. Włókna te wykazują wyjątkowe właściwości, takie jak: duży stosunek powierzch ni do objętości oraz duża porowatość. Znanych jest kilka metod wytwarzania nanowłókien, jednak ze względu na prostotę, powtarzalność i niewielkie koszty, najpowszechniej stosowane jest przędzenie elektrostatyczne. Przedstawiono przegląd najnowszych osiągnięć w zakresie zastosowań nanowłókien polimerowych w medycynie, obejmujący zagadnienia materiałów opatrunkowych, uwalniania sub stancji aktywnych oraz inżynierii tkankowej.Słowa kluczowe: elektroprzędzenie, nanowłókna, zastosowania medyczne.Abstract: Polymer nanofibers are currently of great interest in terms of their potential use in various technological processes, e.g. in the manufacture of textiles or membranes. These fibers are characterized by extraordinary properties such as high surface to volume ratio and high porosity. There are several methods of manufacturing nanofibers, but for reasons of simplicity, repeatability and low cost, elec trostatic spinning is the most common. The article presents a review of the latest developments in the application of polymer nanofibers in medicine, including such issues as bandage materials, release of active substances and tissue engineering.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
