Poly(ε-caprolactone) (PCL) Hollow Nanoparticles with Surface Sealability and On-Demand Pore Generability for Easy Loading and NIR Light-Triggered Release of Drug

Park, Ju Hyang; Kim, Da In; Hong, Sang Gi; Seo, Hojun; Kim, Jong-Bok; Moon, Geon Dae; Hyun, Dong Choon

doi:10.3390/pharmaceutics11100528

Cited by 8 publications

(2 citation statements)

References 40 publications

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“…A similar approach was taken by Park et al, where PCL fibers were loaded with surface openings containing biocompatible photothermal agent. Even though this agent could be used for imaging purposes, in this case it was adapted to be used for triggered release of the drug through NIR Light [ 97 ].…”

Section: Local and Systemic Drug Delivery Systemsmentioning

confidence: 99%

Localized Therapeutic Approaches Based on Micro/Nanofibers for Cancer Treatment

et al. 2023

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Cancer remains one of the most challenging health problems worldwide, and localized therapeutic approaches based on micro/nanofibers have shown potential for its treatment. Micro/nanofibers offer several advantages as a drug delivery system, such as high surface area, tunable pore size, and sustained release properties, which can improve drug efficacy and reduce side effects. In addition, functionalization of these fibers with nanoparticles can enhance their targeting and therapeutic capabilities. Localized delivery of drugs and/or other therapeutic agents via micro/nanofibers can also help to overcome the limitations of systemic administration, such as poor bioavailability and off-target effects. Several studies have shown promising results in preclinical models of cancer, including inhibition of tumor growth and improved survival rates. However, more research is needed to overcome technical and regulatory challenges to bring these approaches to clinical use. Localized therapeutic approaches based on micro/nanofibers hold great promise for the future of cancer treatment, providing a targeted, effective, and minimally invasive alternative to traditional treatments. The main focus of this review is to explore the current treatments utilizing micro/nanofibers, as well as localized drug delivery systems that rely on fibrous structures to deliver and release drugs for the treatment of cancer in a specific area.

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Section: Local and Systemic Drug Delivery Systemsmentioning

confidence: 99%

Localized Therapeutic Approaches Based on Micro/Nanofibers for Cancer Treatment

et al. 2023

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“…As one of the successful ways, researchers have paid attention on designing yolk-shell nanostructure to place active anode materials in hollow protecting layers [17][18][19][20]. Various research has already been done on the yolk-shell nanostructures for applications of drug delivery, sensor, and catalyst [21][22][23][24]. Different from core-shell structure in dense contact, yolk-shell nanostructures create movable space inside the protecting shell, which enables anode to expand without fragmentation or dendrite formation during a chemical reaction.…”

Section: Introductionmentioning

confidence: 99%

Yolk–Shell Nanostructures: Syntheses and Applications for Lithium-Ion Battery Anodes

Moon

2020

Nanomaterials

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Yolk–shell nanostructures have attracted tremendous research interest due to their physicochemical properties and unique morphological features stemming from a movable core within a hollow shell. The structural potential for tuning inner space is the focal point of the yolk–shell nanostructures in a way that they can solve the long-lasted problem such as volume expansion and deterioration of lithium-ion battery electrodes. This review gives a comprehensive overview of the design, synthesis, and battery anode applications of yolk–shell nanostructures. The synthetic strategies for yolk–shell nanostructures consist of two categories: templating and self-templating methods. While the templating approach is straightforward in a way that the inner void is formed by removing the sacrificial layer, the self-templating methods cover various different strategies including galvanic replacement, Kirkendall effect, Ostwald ripening, partial removal of core, core injection, core contraction, and surface-protected etching. The battery anode applications of yolk–shell nanostructures are discussed by dividing into alloying and conversion types with details on the synthetic strategies. A successful design of yolk–shell nanostructures battery anodes achieved the improved reversible capacity compared to their bare morphologies (e.g., no capacity retention in 300 cycles for Si@C yolk–shell vs. capacity fading in 10 cycles for Si@C core–shell). This review ends with a summary and concluding remark yolk–shell nanostructures.

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Polycaprolactone-based nanoparticles for advanced therapeutic applications

Aminu¹,

Audu²

2023

Polymeric Nanosystems

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Poly(ε-caprolactone) (PCL) Hollow Nanoparticles with Surface Sealability and On-Demand Pore Generability for Easy Loading and NIR Light-Triggered Release of Drug

Cited by 8 publications

References 40 publications

Localized Therapeutic Approaches Based on Micro/Nanofibers for Cancer Treatment

Localized Therapeutic Approaches Based on Micro/Nanofibers for Cancer Treatment

Yolk–Shell Nanostructures: Syntheses and Applications for Lithium-Ion Battery Anodes

Polycaprolactone-based nanoparticles for advanced therapeutic applications

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