Poly((D,L)lactic-glycolic)acid&amp;ndash;star glucose nanoparticles for glucose transporter and hypoglycemia-mediated tumor targeting

Park, Ju-Hwan; Cho, Hyun‐Jong; Kim, Dae‐Duk

doi:10.2147/ijn.s147668

Cited by 24 publications

(22 citation statements)

References 45 publications

(55 reference statements)

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“…24 Many studies have revealed that biomaterials designed for controlling cellular activities could regulate glucose metabolism by harnessing the expression of glucose transporters or glycolytic enzymes. 25,26 Besides, ATP produced by glucose metabolism can meet energy demands for many cellular activities, such as enzyme reaction, and electron transfer. 27 However, cellular metabolism not only provides the source of energy but also involves the inflammatory response.…”

Section: Introductionmentioning

confidence: 99%

Improved Immunoregulation of Ultra-Low-Dose Silver Nanoparticle-Loaded TiO2 Nanotubes via M2 Macrophage Polarization by Regulating GLUT1 and Autophagy

Chen¹,

Guan²,

Ren³

et al. 2020

IJN

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Introduction: The bone regeneration of endosseous implanted biomaterials is often impaired by the host immune response, especially macrophage-related inflammation which plays an important role in the bone healing process. Thus, it is a promising strategy to design an osteo-immunomodulatory biomaterial to take advantage of the macrophage-related immune response and improve the osseointegration performance of the implant. Methods: In this study, we developed an antibacterial silver nanoparticle-loaded TiO 2 nanotubes (Ag@TiO 2-NTs) using an electrochemical anodization method to make the surface modification and investigated the influences of Ag@TiO 2-NTs on the macrophage polarization, osteo-immune microenvironment as well as its potential molecular mechanisms in vitro and in vivo. Results: The results showed that Ag@TiO 2-NTs with controlled releasing of ultra-low-dose Ag + ions had the excellent ability to induce the macrophage polarization towards the M2 phenotype and create a suitable osteo-immune microenvironment in vitro, via inhibiting PI3K/Akt, suppressing the downstream effector GLUT1, and activating autophagy. Moreover, Ag@TiO 2-NTs surface could improve bone formation, suppress inflammation, and promote osteo-immune microenvironment compared to the TiO 2-NTs and polished Ti surfaces in vivo. These findings suggested that Ag@TiO 2-NTs with controlled releasing of ultra-low-dose Ag + ions could not only inhibit the inflammation process but also promote the bone healing by inducing healing-associated M2 polarization. Discussion: Using this surface modification strategy to modulate the macrophage-related immune response, rather than prevent the host response, maybe a promising strategy for implant surgeries in the future.

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Section: Introductionmentioning

confidence: 99%

Improved Immunoregulation of Ultra-Low-Dose Silver Nanoparticle-Loaded TiO2 Nanotubes via M2 Macrophage Polarization by Regulating GLUT1 and Autophagy

Chen¹,

Guan²,

Ren³

et al. 2020

IJN

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“…For fluorescence detection of designed NP structures, 1,1′-dioctadecyl-3,3,3′,3′-tetramethylindocarbocyanine perchlorate (Dil) was encapsulated in PLGA NPs as a fluorescence dye. Dil was successfully entrapped in PLGA NPs and the intracellular movement of NPs can be estimated from the fluorescence signals of Dil as reported 41,[48][49][50][51] . In current testing conditions, Dil group exhibited much higher fluorescence intensity compared to DOX group in both A549 and NIH3T3 cells ( Fig.…”

Section: Cellular Internalization and Localization Enhanced Cellularmentioning

confidence: 99%

“…NPs mainly composed of PLGA were fabricated by an emulsification-evaporation method as reported 3,29,41,48,51,58,61 . PLGA (40 mg) dissolved in dichloromethane (1.6 ml) was mixed with dimethyl sulfoxide (DMSO, 0.4 ml).…”

Section: Preparation Of Npsmentioning

confidence: 99%

Possible contribution of sialic acid to the enhanced tumor targeting efficiency of nanoparticles engineered with doxorubicin

Lee

Nam

Koo

et al. 2020

Sci Rep

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Doxorubicin (DOX)-engineered poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) including phloretin (PHL) were designed and the feasible contribution of sialic acid (SA) to the improved tumor targeting and penetration capabilities was elucidated in lung adenocarcinoma models. DOX has been clinically used as liposomal formulations after its introduction to the inner side of vehicles, however DOX is anchored in the outer surface of PLGA NPs for improved tumor penetration by interactions with SA in this study. DOX (positively charged at physiological pH) was adsorbed onto the negatively charged PLGA NPs via electrostatic interactions and consequent binding of SA (negatively charged at physiological pH) to DOX located in NPs was also elucidated. DOX layer in DOX@PLGA NPs rendered improved endocytosis and partial contribution of SA (expressed in cancer cells) to that endocytosis was demonstrated. DOX@PLGA/PHL NPs provided enhanced antiproliferation potentials in A549 cells rather than single agent (DOX or PHL)-installed NPs. In addition, DOX-SA interactions seemed to play critical roles in tumor infiltration and accumulation of DOX@PLGA NPs in A549 tumor-xenografted mouse model. All these findings support the novel use of DOX which is used for the surface engineering of NPs for improved tumor targeting and penetration.

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“…Due to the wide overexpression of various transporters on tumor cell membranes, various transporter-mediated tumor-homing nano-DDS have been developed, including the glucose transporter 83. , 84. , 85.…”

Section: Transporter-mediated Tumor-homing Drug Deliverymentioning

confidence: 99%

“…Among them, glucose transporter-targeted anticancer drug delivery strategies have been attracting increased attention, and several nano-DDS has been developed for efficient cancer therapy, including polymeric nanoparticles and nanomicelles 83. , 84. , 85.…”

Section: Transporter-mediated Tumor-homing Drug Deliverymentioning

confidence: 99%

Emerging transporter-targeted nanoparticulate drug delivery systems

Wang

Liu

et al. 2019

Acta Pharmaceutica Sinica B

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Transporter-targeted nanoparticulate drug delivery systems (nano-DDS) have emerged as promising nanoplatforms for efficient drug delivery. Recently, great progress in transporter-targeted strategies has been made, especially with the rapid developments in nanotherapeutics. In this review, we outline the recent advances in transporter-targeted nano-DDS. First, the emerging transporter-targeted nano-DDS developed to facilitate oral drug delivery are reviewed. These include improvements in the oral absorption of protein and peptide drugs, facilitating the intravenous-to-oral switch in cancer chemotherapy. Secondly, the recent advances in transporter-assisted brain-targeting nano-DDS are discussed, focusing on the specific transporter-based targeting strategies. Recent developments in transporter-mediated tumor-targeting drug delivery are also discussed. Finally, the possible transport mechanisms involved in transporter-mediated endocytosis are highlighted, with special attention to the latest findings of the interactions between membrane transporters and nano-DDS.

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Poly((D,L)lactic-glycolic)acid–star glucose nanoparticles for glucose transporter and hypoglycemia-mediated tumor targeting

Cited by 24 publications

References 45 publications

<p>Improved Immunoregulation of Ultra-Low-Dose Silver Nanoparticle-Loaded TiO<sub>2</sub> Nanotubes via M2 Macrophage Polarization by Regulating GLUT1 and Autophagy</p>

<p>Improved Immunoregulation of Ultra-Low-Dose Silver Nanoparticle-Loaded TiO<sub>2</sub> Nanotubes via M2 Macrophage Polarization by Regulating GLUT1 and Autophagy</p>

Possible contribution of sialic acid to the enhanced tumor targeting efficiency of nanoparticles engineered with doxorubicin

Emerging transporter-targeted nanoparticulate drug delivery systems

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