Poly (d/l) lactide/polycaprolactone/bioactive glasss nanocomposites materials for anterior cruciate ligament reconstruction screws: The effect of glass surface functionalization on mechanical properties and cell behaviors

Esmaeilzadeh, Javad; Hesaraki, Saeed; Hadavi, Seyed Mohammad-Mehdi; Ebrahimzadeh, Mohammad Ali; Esfandeh, Masoud

doi:10.1016/j.msec.2017.03.134

Cited by 21 publications

(19 citation statements)

References 30 publications

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“…Degradation behavior plays an important role in the success of resorbable implants for use in load-bearing applications. In addition to the effects on mechanical performance, the degradation mode can have a substantial effect on long-term clinical benefits [35]; fragmentation degradation of pure polylactide has been shown to result in late complications [36] and rapid delamination of phosphate glass fibers (PGFs) can lead to a mismatch with the rate of bone ingrowth [37,38].…”

Section: Discussionmentioning

confidence: 99%

Polylactide Composite Pins Reinforced with Bioresorbable Continuous Glass Fibers Demonstrating Bone-like Apatite Formation and Spiral Delamination Degradation

Cao

Tian²,

Dong³

et al. 2019

Polymers

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The emergence of polylactide composites reinforced with bioresorbable silicate glass fibers has allowed for the long-term success of biodegradable polymers in load-bearing orthopedic applications. However, few studies have reported on the degradation behavior and bioactivity of such biocomposites. The aim of this work was to investigate the degradation behavior and in vitro bioactivity of a novel biocomposite pin composed of bioresorbable continuous glass fibers and poly-L-D-lactide in simulated body fluid for 78 weeks. As the materials degraded, periodic spiral delamination formed microtubes and funnel-shaped structures in the biocomposite pins. It was speculated that the direction of degradation, from both ends towards the middle of the fibers and from the surface through to the bulk of the polymer matrix, could facilitate bone healing. Following immersion in simulated body fluid, a bone-like apatite layer formed on the biocomposite pins which had a similar composition and structure to natural bone. The sheet- and needle-like apatite nanostructure was doped with sodium, magnesium, and carbonate ions, which acted to lower the Ca/P atomic ratio to less than the stoichiometric apatite and presented a calcium-deficient apatite with low crystallinity. These findings demonstrated the bioactivity of the new biocomposite pins in vitro and their excellent potential for load-bearing applications.

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Section: Discussionmentioning

confidence: 99%

Polylactide Composite Pins Reinforced with Bioresorbable Continuous Glass Fibers Demonstrating Bone-like Apatite Formation and Spiral Delamination Degradation

Cao

Tian²,

Dong³

et al. 2019

Polymers

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“…Additionally, the peaks at 796 cm −1 and 475 cm −1 are assigned, respectively, to symmetric stretching and bending vibrations of Si-O. The band appeared at around 1508 cm −1 is ascribed to N-H bending vibration and the wide peak at 3446 cm −1 is related to overlapped stretching mode of O-H and N-H vibrations (Esmaeilzadeh et al 2017). Figure 2 shows the ATR-FTIR spectra of PCL, PCL-Col-Chit, BG-0.1 and GHK-Cu samples after disinfection and sterilization.…”

Section: Ftir and Atr-ftirmentioning

confidence: 98%

Enhanced biological properties of collagen/chitosan-coated poly(ε-caprolactone) scaffold by surface modification with GHK-Cu peptide and 58S bioglass

et al. 2020

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Bioactive glasses and peptides have shown promising results in improving wound healing and skin repair. The present study explores the effectiveness of surface modification of collagen/chitosan-coated electrospun poly(ε-caprolactone) scaffold with 58S bioactive glass or GHK-Cu peptide. To coat scaffolds with the bioactive glass, we prepared suspensions of silanized bioactive glass powder with three different concentrations and the scaffolds were pipetted with suspensions. Similarly, GHK-Cu-coated scaffolds were prepared by pipetting adequate amount of 1-mM solution of peptide (in milli-Q) on the surface of scaffolds. ATR-FTIR spectroscopy indicated the successful modification of collagen/chitosan-coated electrospun poly(εcaprolactone) scaffold with bioactive glass and GHK-Cu. Microstructural investigations and in vitro studies such as cell adhesion, cell viability and antibacterial assay were performed. All samples demonstrated desirable cell attachment. Compared to poly(ε-caprolactone)/collagen/chitosan, the cell proliferation of GHK-Cu and bioactive glass-coated (concentrations of 0.01 and 0.1) scaffolds increased significantly at days 3 and 7, respectively. Poly(ε-caprolactone)/collagen/chitosan-uncoated scaffold and scaffolds coated with GHK-Cu and bioactive glass revealed desirable antibacterial properties but the antibacterial activity of GHK-Cu-coated sample turned out to be superior. These findings indicated that biological properties of collagen/ chitosan-coated synthetic polymer could be improved by GHK-Cu and bioactive glass.

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“…Accordingly, PLA with a lower degradation rate is used. PLA takes about 5 years to be completely degraded [3,8]. Some companies use lactic acid and glycolic acid copolymer (PLGA) to reduce the rate of degradation and adapt it to the bone reconstruction rate up to 1 year [9].…”

Section: Introductionmentioning

confidence: 99%

“…Some companies use lactic acid and glycolic acid copolymer (PLGA) to reduce the rate of degradation and adapt it to the bone reconstruction rate up to 1 year [9]. Moreover, Esmaeilzadeh et al used the PLA/polycaprolactone blend to improve the toughness of PLA so that the screw comprising this material would show less fracture during application [8]. However, polymers have also some disadvantages; for example, these polymers do not induce bone formation and cannot make good connections with the bone.…”

Section: Introductionmentioning

confidence: 99%

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“Polylactic acid-polyethylene glycol-hydroxyapatite composite” an efficient composition for interference screws

2020

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Interference screws are commonly used for the treatment of ruptured ligaments. The interference screws are often constructed from polylactic acid (PLA). In this study, a melt blend of PLA, polyethylene glycol (PEG) and hydroxyapatite (HA) was investigated for use in interference screws. For this purpose, mechanical properties, differential scanning calorimetry (DSC), degradation rate, pH change, water contact angle, morphology, cytotoxicity, and cell adhesion on the specimens were investigated. According to the tensile test results, by mixing various levels of PLA, PEG, and HA, mechanical properties of the resulting composite can be kept constant or even improved in comparison with pure PLA. DSC proved the miscibility of components and provided a softer product after adding PEG to the mixture. The weight loss of samples was investigated over a period of 7 months and the results indicated an increase in the degradation rate by increasing PEG level. pH changes were also investigated indicating no significant change in pH. The contact angle test showed an increase in the hydrophilic nature of all specimens with increasing PEG and HA levels. Surface morphology was studied by scanning electron microscope (SEM) and the results showed an increase in toughness with increasing PEG level. 2 mm HA particles and HA agglomeration in some areas were clearly observed in the SEM micrographs. According to the MTT test, none of the samples caused cell death, and results also showed good and spread cell adhesion to the specimens.

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Poly (d/l) lactide/polycaprolactone/bioactive glasss nanocomposites materials for anterior cruciate ligament reconstruction screws: The effect of glass surface functionalization on mechanical properties and cell behaviors

Cited by 21 publications

References 30 publications

Polylactide Composite Pins Reinforced with Bioresorbable Continuous Glass Fibers Demonstrating Bone-like Apatite Formation and Spiral Delamination Degradation

Polylactide Composite Pins Reinforced with Bioresorbable Continuous Glass Fibers Demonstrating Bone-like Apatite Formation and Spiral Delamination Degradation

Enhanced biological properties of collagen/chitosan-coated poly(ε-caprolactone) scaffold by surface modification with GHK-Cu peptide and 58S bioglass

“Polylactic acid-polyethylene glycol-hydroxyapatite composite” an efficient composition for interference screws

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