Poly(d,l-lactide-ran-ε-caprolactone)-poly(ethylene glycol)-poly(d,l-lactide-ran-ε-caprolactone) as parenteral drug-delivery systems

Cho, Hanjin; Chung, Dongjun; An, Jia

doi:10.1016/j.biomaterials.2003.09.106

Cited by 40 publications

(21 citation statements)

References 24 publications

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“…Since 5-FU is hydrophilic it may possibly have partitioned more in the hydrophilic domains than into the hydrophobic domains. Similar results were obtained by Cho et al (2004). The group reported the preparation of long circulating nanoparticles of poly (d,l-lactide-ran-ε-caprolactone)-poly(ethylene glycol) poly (d,l-lactide-ran-ε-caprolactone) as parenteral drug-delivery systems for 5-FU delivery.…”

Section: Entrapment Efficiencysupporting

confidence: 74%

Development and characterization of hyaluronic acid decorated PLGA nanoparticles for delivery of 5-fluorouracil

et al. 2010

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Section: Entrapment Efficiencysupporting

confidence: 74%

Development and characterization of hyaluronic acid decorated PLGA nanoparticles for delivery of 5-fluorouracil

et al. 2010

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“…[16][17][18][19][20] Recently, new biodegradable copolymer which is based on the both of aforementioned approach, that is random copolymerization of PLA and PCL and introduction of PEG onto aliphatic polyester, has been reported by us and other workers. [21][22][23][24][25] Because the crystallinity which affects the rate of degradation of this kind of biodegradable poly(esterether) can be controlled by adjusting the weight ratio of L-lactide and ε-caprolactone segments and sequence distribution of segment, 26,27 not only composition of the copolymer but chemical microstructure is important for the taylormade application of new polymer.…”

Section: Introductionmentioning

confidence: 99%

Effect of composition and synthetic route on the microstructure of biodegradable diblock copolymer, poly(ε-caprolactone-co-L-lactide)-b-poly(ethylene glycol)

et al. 2008

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Biodegradable poly(ε-caprolactone-co-L-lactide)-b-poly(ethylene glycol) (PCLA-b-PEG) copolymers were synthesized via solution polymerization by varying the feed composition of ε-caprolactone (ε-CL) and L-lactide (LLA) (ε-CL: LLA=10:0, 7:3, 5:5, 3:7, 0:10). The feed ratio based on weight is in accordance with the copolymer composition except for the case of ε-CL: LLA=3:7 (C3L7), which was verified by 1 H-NMR. Two different approaches were used for the exceptional case, which is an extension of the reaction time or the sequential introduction of the monomer. A copolymer composition of ε-CL: LLA=3:7 could be obtained in either case. The chemical microstructure of PCLA-b-PEG was determined using the 1 3 C-NMR spectra and the effect of the sequential structure on the thermal properties and crystallinity were examined. Despite the same composition ratio of the copolymer, the microstructure can differ according to the reaction conditions.

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“…[7][8][9] Therefore, a number of studies have focused on the applications of the polymeric self-aggregates into drug delivery systems. [10][11][12][13][14][15] As polymeric materials for the self-aggregate, amphiphilic block copolymers, hydrophobically modified water-soluble polymers, and hydrophobized polysaccharides have been extensively studies. [16][17][18][19][20] Poly(ethylene glycol) (PEG), the hydrophilic corona, endowed the polymeric micelles with escape from nonspecific uptake by reticuloendothelial systems (RES).…”

Section: Introductionmentioning

confidence: 99%

Preparation and characterization of nanoparticles using poly(N-isopropylacrylamide)-poly(ε-caprolactone) and poly(ethylene glycol)-poly(ε-caprolactone) block copolymers with thermosensitive function

2007

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Thermosensitive nanoparticles were prepared via the self-assembly of two different poly(ε-caprolactone)-based block copolymers of poly(N-isopropylacrylamide)-b-poly(ε-caprolactone) (PNPCL) and poly(ethylene glycol)-b-poly(ε-caprolactone) (PEGCL). The self-aggregation and thermosensitive behaviors of the mixed nanoparticles were investigated using 1 H-NMR, turbidimetry, differential scanning microcalorimetry (micro-DSC), dynamic light scattering (DLS), and fluorescence spectroscopy. The copolymer mixtures (mixed nanoparticles, M1-M5, with different PNPCL content) formed nano-sized self-aggregates in an aqueous environment via the intra-and/ or intermolecular association of hydrophobic PCL chains. The microscopic investigation of the mixed nanoparticles showed that the critical aggregation concentration (cac), the partition equilibrium constants (K v ) of pyrene, and the aggregation number of PCL chains per one hydrophobic microdomain varied in accordance with the compositions of the mixed nanoparticles. Furthermore, the PNPCL harboring mixed nanoparticles evidenced phase transition behavior, originated by coil to the globule transition of PNiPAAm block upon heating, thereby resulting in the turbidity change, endothermic heat exchange, and particle size reduction upon heating. The drug release tests showed that the formation of the thermosensitive hydrogel layer enhanced the sustained drug release patterns by functioning as an additional diffusion barrier.

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Poly(d,l-lactide-ran-ε-caprolactone)-poly(ethylene glycol)-poly(d,l-lactide-ran-ε-caprolactone) as parenteral drug-delivery systems

Cited by 40 publications

References 24 publications

Development and characterization of hyaluronic acid decorated PLGA nanoparticles for delivery of 5-fluorouracil

Development and characterization of hyaluronic acid decorated PLGA nanoparticles for delivery of 5-fluorouracil

Effect of composition and synthetic route on the microstructure of biodegradable diblock copolymer, poly(ε-caprolactone-co-L-lactide)-b-poly(ethylene glycol)

Preparation and characterization of nanoparticles using poly(N-isopropylacrylamide)-poly(ε-caprolactone) and poly(ethylene glycol)-poly(ε-caprolactone) block copolymers with thermosensitive function

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