Poly(dimethylsiloxane)-Based Packaging Technique for Microchip Fluorescence Detection System Applications

Kim, Young‐Hwan; Shin, Kyung Sook; Kang, Jungwon; Yang, Eungyeong; Paek, Kyeong-Kap; Seo, Dae Shik; Ju, Byeong−Kwon

doi:10.1109/jmems.2006.880355

Cited by 31 publications

(9 citation statements)

References 25 publications

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“…Highlighting the need to miniaturize their entire LoC system, Shin and Kim et al investigated a fully integrated microfluidic system with an Alq 3 OLED excitation source and a p-i-n Si PD [71,72]. The microchannel itself was etched in glass, and the OLED was deposited onto the same glass substrate.…”

Section: Organic Light Emitting Diode-integrated Lab-on-a-chip Systemsmentioning

confidence: 99%

Integration of Organic Light Emitting Diodes and Organic Photodetectors for Lab-on-a-Chip Bio-Detection Systems

2014

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The rapid development of microfluidics and lab-on-a-chip (LoC) technologies have allowed for the efficient separation and manipulation of various biomaterials, including many diagnostically relevant species. Organic electronics have similarly enjoyed a great deal of research, resulting in tiny, highly efficient, wavelength-selective organic light-emitting diodes (OLEDs) and organic photodetectors (OPDs). We consider the blend of these technologies for rapid detection and diagnosis of biological species. In the ideal system, optically active or fluorescently labelled biological species can be probed via light emission from OLEDs, and their subsequent light emission can be detected with OPDs. The relatively low cost and simple fabrication of the organic electronic devices suggests the possibility of disposable test arrays. Further, with full integration, the finalized system can be miniaturized and made simple to use. In this review, we consider the design constraints of OLEDs and OPDs required to achieve fully organic electronic optical bio-detection systems. Current approaches to integrated LoC optical sensing are first discussed. Fully realized OLED-and OPD-specific photoluminescence detection systems from literature are then examined, with a specific focus on their ultimate limits of detection. The review highlights the enormous potential in OLEDs and OPDs for integrated optical sensing, and notes the key avenues of research for cheap and powerful LoC bio-detection systems.

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Section: Organic Light Emitting Diode-integrated Lab-on-a-chip Systemsmentioning

confidence: 99%

Integration of Organic Light Emitting Diodes and Organic Photodetectors for Lab-on-a-Chip Bio-Detection Systems

2014

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“…Destandau et al (2007) have reported a simple Yshaped microfluidic channel and a simple LED and PMT detecting potassium with a LoD of 0.5 mM using calyxbodipy dye, which has fluorescence intensity sensitive to potassium concentration. Kim et al (2006) realised a highly integrated fluorescent microfluidic detection chip comprising the microfluidic channels, silicon detector with interference filter, and an integrated organic LED (OLED) deposited directly on to glass as a thin-film structure. The microchannels were etched in glass with dimensions 70 lm width and 20 lm depth, and the OLED, emitting at 530 nm, was deposited on the reverse of the substrate.…”

Section: Fluorescence Detectionmentioning

confidence: 99%

Optofluidic integration for microanalysis

Hunt

Wilkinson

2007

Microfluid Nanofluid

130

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This review describes recent research in the application of optical techniques to microfluidic systems for chemical and biochemical analysis. The ''lab-on-achip'' presents great benefits in terms of reagent and sample consumption, speed, precision, and automation of analysis, and thus cost and ease of use, resulting in rapidly escalating adoption of microfluidic approaches. The use of light for detection of particles and chemical species within these systems is widespread because of the sensitivity and specificity which can be achieved, and optical trapping, manipulation and sorting of particles show significant benefits in terms of discrimination and reconfigurability. Nonetheless, the full integration of optical functions within microfluidic chips is in its infancy, and this review aims to highlight approaches, which may contribute to further miniaturisation and integration.

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“…To realize the microchips enabling various optical measurements, the following two technologies are strongly desired to be developed; at first, miniaturization of optical components such as the light sources, lenses, waveguides, microfluidic channels, and detectors, and convenient integration methods of them on a single chip are important [4][5][6][7]. Organic optical materials such as polymer and low molecular thin films are good candidates for this purpose because of their material flexibilities and ease in fabrication of the thin film.…”

Section: Introductionmentioning

confidence: 99%

Photoinduced absorption measurement on a microchip equipped with organic dye-doped polymer waveguide

Kawaguchi

Nagai

Yamashita

2013

Optical Sensors 2013

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We have fabricated a waveguide-type optical sensing microchip and succeeded in on-chip photoinduced absorption (PIA) spectroscopy. The PIA microchip was fabricated with a conventional photolithographic technique and consisted of plastic optical waveguides and microfluidic channels. Furthermore, a serially-cascaded polymer waveguide doped with organic dyes was integrated on this microchip, which was fabricated using a self-written waveguide process. This dye-doped waveguide was pumped by a UV light-emitting diode (UV-LED) and used as a probe light source with a broad emission spectrum. At the same time, a solution of test material in the microfluidic channel was synchronously pumped by a UV-LED or UV laser diode. Since the transmission spectrum of the photo-excited test material could be measured, the PIA spectra were obtained easily. In this study, we have demonstrated the on-chip PIA measurements for two classes of test materials, rare-earth complex and chlorophyll molecules. In the measurement for the aqueous solution of Neodymium (III) acetate hydrate, PIA signals attributed to the 4f-4f transition was observed. Furthermore, by varying the modulation frequency of the pulsed optical pumping, lifetime analysis of the excited 4f states was achieved. In the measurements for the ethanol solutions of chlorophyll a and chlorophyll b, PIA signals were observed at the wavelength near the Q-band absorption peaks. These spectra were very similar to the well-known feature for the photosystem II protein complex observed in a conventional PIA system. From these results, it is expected that the onchip PIA measurement technique is applicable to the transient analyses for the material systems with photoexcited charge transfer.

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Poly(dimethylsiloxane)-Based Packaging Technique for Microchip Fluorescence Detection System Applications

Cited by 31 publications

References 25 publications

Integration of Organic Light Emitting Diodes and Organic Photodetectors for Lab-on-a-Chip Bio-Detection Systems

Integration of Organic Light Emitting Diodes and Organic Photodetectors for Lab-on-a-Chip Bio-Detection Systems

Optofluidic integration for microanalysis

Photoinduced absorption measurement on a microchip equipped with organic dye-doped polymer waveguide

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