Poly(ester amide)s derived from 1,4-butanediol, adipic acid and 6-aminohexanoic acid

Lozano, Miguel González; Franco, Lourdes; Rodríguez‐Galán, Alfonso; Puiggalı́, Jordi

doi:10.1016/j.polymdegradstab.2003.11.018

Cited by 12 publications

(1 citation statement)

References 10 publications

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“…These PEAs as potential biodegradable materials became fundamental for the extension of further biomedical applications. There also emerged many more derivatives from diacids, diamines, or diols being used into the PEA polymerization as shown in Figure . − …”

Section: Synthesis Of Poly(ester Amide)smentioning

confidence: 99%

Recent Advances of Poly(ester amide)s-Based Biomaterials

Han

2022

Biomacromolecules

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Biodegradable and biocompatible biomaterials have offered much more opportunities from an engineering standpoint for treating diseases and maintaining health. Poly(ester amide)s (PEAs), as an outstanding family among such biomaterials, have risen overwhelmingly in the past decades. These synthetic polymers have easily and widely available raw materials and a diversity of synthetic approaches, which have attracted considerable attention. More importantly, combining the superiorities of polyamides and polyesters, PEAs have emerged with better functions. They could have improved biodegradability, biocompatibility, and cell− material interactions. The PEAs derived from α-amino acids even allow the introduction of pendant sites for further modification or functionalization. Meanwhile, it is gradually recognized that the chemical structures are closely related to the physiochemical and biological properties of PEAs so that their properties can be precisely controlled. PEAs therefore become significant materials in the biomedical fields. This review will attempt to summarize the recent progress in the development of PEAs with respect to the preparation materials and methods, structure−property relationships along with their latest biomedical accomplishments, especially for drug delivery and tissue engineering.

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Section: Synthesis Of Poly(ester Amide)smentioning

confidence: 99%

Recent Advances of Poly(ester amide)s-Based Biomaterials

Han

2022

Biomacromolecules

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Synthesis of poly(ester amide)s by the melt polycondensation of semiaromatic polyesters with ethanolamine and their characterization

Harashina

Nakane²,

Itoh

2007

J. Polym. Sci. A Polym. Chem.

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Semiaromatic poly(ester amide)s (PEAs) were synthesized by the melt polycondensation of ethanolamine (EA) derivatives with dimethyl terephthalate and ethylene glycol in the presence of tetrabutyl titanate as a catalyst, and their crystallization and thermal properties were investigated. The introduction of an amide group into a semiaromatic polyester such as poly(ethylene terephthalate) (PET) produced PEAs (EA-modified PET polymers) with an increase in the melting point. However, these PEAs were found to decompose at a lower temperature than PET on the basis of TGA. Moreover, direct pyrolysis/mass spectrometry measurements suggested that an initial step of the thermal decomposition was a b-CH hydrogen-transfer reaction via a six-member ring transition state at the ester-ethylene-amide unit, at which carbonoxygen bond scission took place to yield carboxyl and N-vinylamide end groups. Furthermore, molecular orbital calculations using trimer models bis [2-[[4-(methoxycarbonyl)benzoyl]oxy]ethyl]terephthalate, N-[2-[[4-(methoxycarbonyl)benzoyl]oxy]ethyl]-4-[2-[[4-(methoxycarbonyl)benzoyl]oxy]ethyloxycarbonyl]benzamide, and N,N 0 -bis[2-[[4-(methoxycarbonyl)benzoyl]oxy]ethyl]terephthalamide strongly supported the idea that the b-CH hydrogen-transfer reaction in the thermal decomposition of PEAs might occur more easily at the methylene group next to the amide group in an ester-ethylene-amide unit rather than at the methylene group next to the ester group in an ester-ethylene-ester unit.

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Properties and applications

Rudnik¹

2019

Compostable Polymer Materials

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Poly(ester amide)s derived from 1,4-butanediol, adipic acid and 6-aminohexanoic acid

Cited by 12 publications

References 10 publications

Recent Advances of Poly(ester amide)s-Based Biomaterials

Recent Advances of Poly(ester amide)s-Based Biomaterials

Synthesis of poly(ester amide)s by the melt polycondensation of semiaromatic polyesters with ethanolamine and their characterization

Properties and applications

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