Poly(ester amides) (PEAs) – Scaffold for tissue engineering applications

Ghosal, Kajal; Latha, M S; Thomas, Sabu

doi:10.1016/j.eurpolymj.2014.08.006

Cited by 67 publications

(47 citation statements)

References 86 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The lower drying rate and the higher temperature of SD process provide sufficient time and mobility for nucleation of a readily crystallizing API (such as caffeine). In contrast, the drying and solidification processes are extremely rapid when fibers of large specific surface area is formed by ES method [1], furthermore, the diffusion, required for nucleation, is limited in the formed fibers owing to the partially oriented polymer chains and the excellent diffusion barrier properties of the fiber-air interfaces. Thus, even strongly crystallizing active substances can be kept in amorphous form.…”

Section: Xrdmentioning

confidence: 97%

“…The methods assigned for this purpose should be gentle and productive enough allowing efficient manufacturing on industrial scale. Although both the well-known spray drying (SD) and the recently introduced electrospinning (ES) techniques have been already used for forming controlled release formulations [1][2][3][4][5], these were, surprisingly, not yet tested with the same formulation comparing their capability.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Preparation and comparison of spray dried and electrospun bioresorbable drug delivery systems

Sóti

Nagy

Serneels³

et al. 2015

European Polymer Journal

View full text Add to dashboard Cite

a b s t r a c tTwo continuous processes, the spray drying method, producing microparticles in presence of hot gas flow, and the electrospinning technology, producing continuous polymer nanofibers at low temperature under high electric fields, were investigated and compared the first time. Both techniques were used to prepare slow release caffeine (as a model of rapidly water-soluble drug) using water-insoluble, biocompatible and bioresorbable PLGA and PLA as polymeric matrix. The structural characterization of the obtained samples was performed using SEM, XRD, DSC and at-line Raman mapping, while in vitro dissolution was detected by UV spectrophotometer. We found that the release profile of a highly water soluble drug can be adjusted to the requirements through the investigated continuous technologies. Solid molecular dispersion of caffeine at colloidal level could be prepared in PLA matrix using electrostatic spinning. Furthermore the continuous nonwoven structure of ultrafine fibers, produced this way, allows easer handling than that of independent fine particle's. On the other hand continuous production of drug loaded microspheres with slightly less performance can be performed with the conventional technology of spray drying which is well known in the pharmaceutical industry.

show abstract

Section: Xrdmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Preparation and comparison of spray dried and electrospun bioresorbable drug delivery systems

Sóti

Nagy

Serneels³

et al. 2015

European Polymer Journal

View full text Add to dashboard Cite

show abstract

“…Applications of porous electrospun fibres can range from sorbent materials for oil spill clean-up [4] to moisture wicking materials for sportwear [5]. Biomedical applications of these materials include scaffolds for tissue engineering [6][7] and carriers for drug delivery [8]. In tissue engineering, the porous fibres can mimic the native extracellular matrix (ECM) and the surface pores facilitate cell attachment, which is important for the restoration and regeneration of damaged tissue and organs [9].…”

Section: Introductionmentioning

confidence: 99%

Fabricating porous poly(lactic acid) fibres via electrospinning

Huang

Thomas

2018

European Polymer Journal

161

115

View full text Add to dashboard Cite

In this paper, amorphous poly(lactic acid) (PLA), a biodegradable polymer with excellent biocompatibility, is successfully electrospun into micron-sized fibres with controlled surface and internal morphologies. By careful solvent selection, either surface porosity or internal porosity can be achieved through different mechanisms. Use of chloroform as the solvent gives rise to circular pores of 100 nm diameter confined to the surface. These are obtained in humid conditions by the so-called 'Breath Figure' mechanism. It is found that combining chloroform with a water-miscible non-solvent yields either surface porosity (wrinkled effect) using a low boiling point liquid, e.g. ethanol, or internal porosity using a high boiling point liquid, e.g. dimethyl sulphoxide (DMSO). Both these microstructures are obtained through a non-solvent induced phase separation (NIPS) mechanism. Finally, it is found possible to produce both surface and internal porosity using DMSO by a vapour induced phase separation (VIPS) mechanism. The porous electrospun PLA mats were shown to exhibit significantly increased oil absorption capacity compared with the non-porous fibre mats.

show abstract

“…For example, polycaprolactone, often used in tissue engineering, is known for its excellent biocompatibility, but also for its poor thermal and mechanical properties [9]. Polymers, such as polyamides, overcome these drawbacks through blending or incorporation into copolymers, or by modification of their side-chains to introduce the desired physical properties [10][11][12][13]. Polyethylene glycol (PEG) has also proven to be a synthetic polymer with excellent biocompatibility for use in many biomedical applications [14,15].…”

Section: Introductionmentioning

confidence: 99%