Poly(ethylene glycol) based nanotubes for tuneable drug delivery to glioblastoma multiforme

Abstract

Glioblastoma multiforme (GBM) is the most aggressive type of malignant brain tumour, which is associated with a poor two-year survival rate and a high rate of fatal recurrence near the...

Photocurable Acrylic-Resin-Based Tubular Micromotors with Smart External Surfaces

“…of 284 ± 26 nm (Figure C, S1B). The apparently rigid structure is consistent with the findings reported earlier. , The W.T. slightly increased compared with the value before the LbL deposition (260 → 284 nm).…”

“…The use of photocurable acrylic resins as wall materials opens avenues for designing diverse polymer tubes with desired physicochemical properties, thereby expanding their range of applications. Newland et al demonstrated the synthesis of poly­(ethylene glycol) (PEG)-based nanotubes through the photopolymerization of PEG-diacrylate in an anodized aluminum oxide (AAO) membrane. , The resulting soft and flexible PEG tubes exhibited good cytocompatibility and the ability to load the anticancer agent doxorubicin in the wall. However, dissolution of the hard AAO template using aqueous NaOH partially destroyed (hydrolyzed) the polymer tubes.…”

“…First, the introduction of cross-linking was implemented to mitigate the risk of tube damage during template etching in organic solvent, typically N , N -dimethylformamide (DMF). Newland et al demonstrated that the use of a shorter chain length of bis­[2-(methacryloyloxy)­ethyl]­phosphate (BMP) monomer resulted in a higher cross-linking density and a more robust structure. , Second, the negative charges of the phosphate polymer facilitate the electrostatic binding of functional molecules on the curved surfaces. Here, we present a distinctive synthesis of photocurable acrylic-resin-based tubular micromotors featuring a PtNP engine layer as an internal wall and a distinct smart layer as an external wall [8 μm outer diameter (O.D.…”

Well-Defined Polyethylene Glycol Microscale Hydrogel Blocks Containing Gold Nanorods for Dual Photothermal and Chemotherapeutic Therapy

“…At 4 h and then 1, 2, 3, 6 and 7 days, PBS was removed and stored (−80 °C) and replaced with fresh PBS. Then, 100 µL of the samples was analyzed by absorbance at 482 nm (Spark ® plate reader (Tecan Trading AG, Männedorf, Switzerland) in comparison to a standard curve as reported previously [ 25 ]. Four replicates were undertaken, and a mean value was used.…”

Bottom‐Up versus Top‐Down Strategies for Morphology Control in Polymer‐Based Biomedical Materials

“…Templating lithographic methods have been extensively used for patterning in electronics, and in soft lithography for microfluidic chip preparation, [91] but were adapted to be used as micrometer and submicrometer particle fabrication techniques around 2005. [92] In general, templatebased methods involve preparation of a master template from silica with etching (or other porous inorganic materials), [93,94] and secondary templates formed from either polydimethylsiloxane (PDMS) or water-soluble sacrificial polyvinylalcohol templates, with particles being fabricated directly in the template pattern and subsequently collected. [95,96] The particle replication in nonwetting templates (PRINT) methodology was developed by the DeSimone and co-workers, and has allowed synthesis of polymeric nanoparticles of well-defined geometries from tens of nanometers to micrometers.…”