Poly{dl‐lactide‐b‐[oligo(ethylene glycol) methyl ether (meth)acrylate)]} block copolymers. Synthesis, characterization, micellization behavior in aqueous solutions and encapsulation of model hydrophobic compounds

Abstract

A series of well-defined poly{DL-lactide-b-[oligo(ethylene glycol) methyl ether (meth)acrylate)]} (PDLLA-b-POEG[M]A) functional amphiphilic diblock copolymers was synthesized by employing a multistep procedure involving: (a) ring-opening polymerization of DL-lactide using n-decanol and stannous octoate as the initiating system, (b) esterification reaction of the PDLLA hydroxyl end groups with 2-bromoisobutyryl bromide, (c) atom transfer radical polymerization of OEG(M)A with the newly created bromoisobutyryl initiating site, and (d) incorporation of biotin or folic acid at the POEGA chain ends

Nano-Assemblies from Amphiphilic PnBA-b-POEGA Copolymers as Drug Nanocarriers

“…To date, several scientific works have utilized POEG[M]A blocks for the formation of micelles from AmBCs [ 15 , 16 , 17 ]. Moreover, the OEG fragment endows polymeric systems with “stealth” properties, preventing their recognition by the immune system [ 18 , 19 ].…”

Novel degradable amphiphilic 4-arm star PLA-b-POEOA and PLGA-b-POEOA block copolymers: synthesis, characterization and self-assembly

“…To the best of our knowledge there is only one report dealing with the synthesis of well-defined linear PLA- b -POEOA BCPs with M n = 8100 and M n = 20 300 using high concentration of metal catalyst. 28 The authors incorporated folic acid and biotin into the hydrophilic POEOA blocks to introduce functional biomolecules into the periphery of the micelles formed by the PLA- b -POEOA copolymer. However, the degradation and cytocompatibility of the polymers were not investigated.…”

Micellar drug delivery vehicles formed from amphiphilic block copolymers bearing photo-cross-linkable cyclopentenone side groups

“…Both compounds are incompatible with the aqueous environment and are commonly used to probe micellar loading efficiency. [52][53][54] The solvent exchange method results in optically clear liquids for the pyrene loaded micelles, and in the case of Nile red encapsulated micelles, the liquid turned red (Fig. S11 †).…”