Poly-L-lysine designed magnetic nanoparticles for combined hyperthermia, magnetic resonance imaging and cancer cell detection

Kubovčíková, Martina; Koneracká, M.; Štrbák, Oliver; Molčan, Matúš; Závišová, V.; Antal, Iryna; Khmara, Iryna; Lucanska, Dasa; Tomčo, L.; Baráthová, Monika; Zaťovičová, Miriam; Dobrota, Dušan; Pastoreková, Silvia; Kopčanský, P.

doi:10.1016/j.jmmm.2018.11.027

Cited by 33 publications

(20 citation statements)

References 19 publications

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“…Heparin is a commonly used anticoagulant in clinic and it mediates the ATIII inhibition of blood coagulation (Park, ), it also can bind to biological factors at specific binding sites and protect the activity of the factors simultaneously. PLL, a cationic polyelectrolyte, has been used for transfection and gene loading frequently (Kubovcikova et al, ; Zhou et al, ). In a previous study conducted by our team, negatively charged heparin and positively charged PLL were used to create nanoparticles by strongly electrostatic interaction.…”

Section: Discussionmentioning

confidence: 99%

Heparin/poly‐l‐lysine nanoplatform with growth factor delivery for surface modification of cardiovascular stents: The influence of vascular endothelial growth factor loading

Tan

Cui

Zeng

et al. 2020

J Biomedical Materials Res

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The rapid re‐endothelialization of the vascular stent surface is desirable for preventing thrombosis or reducing restenosis. Many biological factors that promote the biological behavior of endothelial cells have been used for the surface modification of stents. Vascular endothelial growth factor (VEGF), which plays an important role in angiogenesis, induces strong vascular growth. In this study, we investigated different VEGF concentrations (50 to 500 ng/ml) to determine the optimum concentration for biocompatibility. First, VEGF‐loaded heparin/poly‐l‐lysine (Hep‐PLL) nanoparticles were created by electrostatic interactions. Then, the VEGF‐loaded nanoparticles were immobilized on dopamine‐coated 316 L stainless steel (SS) surfaces. The physical and chemical properties of the modified surface were characterized and the biocompatibility was evaluated in vitro. The results indicated that the VEGF‐loaded nanoparticles were immobilized successfully on the 316LSS surface, as evidenced by the results of Alcian Blue staining and water contact angle (WCA) measurements. The low platelet adhesion and activation indicated that the modified surfaces had good blood compatibility. The modified surfaces showed a good inhibitory effect on smooth muscle cells, indicating that they inhibited tissue hyperplasia. In addition, the modified surfaces significantly promoted endothelial cell adhesion, proliferation, migration, and biological activity, especially VEGF concentration was 350 ng/ml (NPV350). The optical VEGF concentration of the surface modified Hep‐PLL nanoparticles was 350 ng/ml. The proposed method shows promise for potential applications for cardiovascular devices.

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Section: Discussionmentioning

confidence: 99%

Heparin/poly‐l‐lysine nanoplatform with growth factor delivery for surface modification of cardiovascular stents: The influence of vascular endothelial growth factor loading

Tan

Cui

Zeng

et al. 2020

J Biomedical Materials Res

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“…MRI is related to nuclear magnetic resonance of hydrogen atoms and it usually requires the use of contrast agents for enhanced imaging. MNPs can be used as contrast agents only if they exhibit high saturation magnetization and after functionalization with compounds that increase the hydrophilicity around the Fe 2 O 4 core [83].…”

Section: Cancer Treatment Using Magnetic Nanoparticlesmentioning

confidence: 99%

“…This strategy offers greatly improved survival rates among oncological patient's response to therapy. A first approach presents MNPs based on Fe 3 O 4 , having the core diameter of about 10 nm functionalized with poly-L-lysine (PLL) [83]. This complex strategy increases the stability and biocompatibility of MNPs and allows their use for combined detection, diagnosis through MRI and cancer therapy through magnetic hyperthermia.…”

Section: Cancer Treatment Using Magnetic Nanoparticlesmentioning

confidence: 99%

“…However, magnetic hyperthermia using MNPs brings significant advantages in comparison with other hyperthermia treatments as it is possible to adjust the proper amount of MNPs and these can be delivered in the proper location [93]. During magnetic hyperthermia treatment, the MNPs are firstly injected directly into the tumor, followed by the application of a high-frequency alternating magnetic field, a process that causes local heating and finally thermal destruction of the tumor [83]. The strength and frequency of the magnetic field, the size and amount of MNPs are some important parameters that determine the efficiency of heat generation for successful cancer therapy [3].…”

Section: Hyperthermiamentioning

confidence: 99%

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Implication of Magnetic Nanoparticles in Cancer Detection, Screening and Treatment

2019

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During the last few decades, magnetic nanoparticles have been evaluated as promising materials in the field of cancer detection, screening, and treatment. Early diagnosis and screening of cancer may be achieved using magnetic nanoparticles either within the magnetic resonance imaging technique and/or sensing systems. These sensors are designed to selectively detect specific biomarkers, compounds that can be related to the onset or evolution of cancer, during and after the treatment of this widespread disease. Some of the particular properties of magnetic nanoparticles are extensively exploited in cancer therapy as drug delivery agents to selectively target the envisaged location by tailored in vivo manipulation using an external magnetic field. Furthermore, individualized treatment with antineoplastic drugs may be combined with magnetic resonance imaging to achieve an efficient therapy. This review summarizes the studies about the implications of magnetic nanoparticles in cancer diagnosis, treatment and drug delivery as well as prospects for future development and challenges of magnetic nanoparticles in the field of oncology.

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“…Furthermore, biomedical applications require high magnetization values and sizes typically smaller than 100 nm with a narrow distribution, which is possible to achieve with iron oxide nanoparticles [12][13][14][15][16]. An important aspect is also the use of an appropriate biocompatible coating; hydrophilic coatings are commonly based on polysaccharides and polypeptides, while hydrophobic coatings are commonly based on surfactants [16][17][18]. Particle size reduction may affect the ratio between the thermal energy and the product of magnetic anisotropy and particle volume, such that the superparamagnetic limit can be crossed, which strongly determines the magnetic behavior of the particle.…”

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confidence: 99%

Hydrophobically Coated Superparamagnetic Iron Oxides Nanoparticles Incorporated into Polymer-Based Nanocapsules Dispersed in Water

et al. 2020

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This paper reports the characterization of iron oxide magnetic nanoparticles obtained via the thermal decomposition of an organometallic precursor, which were then loaded into nanocapsules prepared via the emulsification process in the presence of an amphiphilic derivative of chitosan. The applied synthetic method led to the formation of a hydrophobic layer on the surface of nanoparticles that enabled their loading in the hydrophobic liquid inside of the polymer-based capsules. The average diameter of nanoparticles was determined to be equal to 15 nm, and they were thoroughly characterized using X-ray diffraction (XRD), magnetometry, and Mössbauer spectroscopy. A core-shell structure consisting of a wüstite core and maghemite-like shell was revealed, resulting in an exchange bias effect and a considerable magnetocrystalline anisotropy at low temperatures and a superparamagnetic behavior at room temperature. Importantly, superparamagnetic behavior was observed for the aqueous dispersion of the nanocapsules loaded with the superparamagnetic nanoparticles, and the dispersion was shown to be very stable (at least 48 weeks). The results were analyzed and discussed with respect to the potential future applications of these nanoparticles and nanocapsules based on biopolymers as platforms designed for the magnetically navigated transport of encapsulated hydrophobic substances.

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Poly-L-lysine designed magnetic nanoparticles for combined hyperthermia, magnetic resonance imaging and cancer cell detection

Cited by 33 publications

References 19 publications

Heparin/poly‐l‐lysine nanoplatform with growth factor delivery for surface modification of cardiovascular stents: The influence of vascular endothelial growth factor loading

Heparin/poly‐l‐lysine nanoplatform with growth factor delivery for surface modification of cardiovascular stents: The influence of vascular endothelial growth factor loading

Implication of Magnetic Nanoparticles in Cancer Detection, Screening and Treatment

Hydrophobically Coated Superparamagnetic Iron Oxides Nanoparticles Incorporated into Polymer-Based Nanocapsules Dispersed in Water

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