Poly(lactic acid)-coated mesoporous silica nanosphere for controlled release of venlafaxine

Tang, Jing; Slowing, Igor I.; Huang, Yangen; Trewyn, Brian G.; Hu, Jun; Liu, Honglai; Lin, Victor S.‐Y.

doi:10.1016/j.jcis.2011.05.027

Cited by 43 publications

(17 citation statements)

References 34 publications

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“…Biodegradable aliphatic polyester (PLA) coating is incorporated as a gatekeeping layer that can control the release of drug. These PLA coatings have been used in the past under intestinal conditions to delay the release of venlafaxine from the mesoporous silica nanospheres . Additionally, it has been observed that ROS can hasten the degradation of such PLA coatings, that is why Shen at al used PLA as a ROS‐responsive gate keeper for MSNs to secure effective drug release in high oxidative stress conditions .…”

Section: Applications Of Msnsmentioning

confidence: 99%

Multidisciplinary Role of Mesoporous Silica Nanoparticles in Brain Regeneration and Cancers: From Crossing the Blood–Brain Barrier to Treatment

Mendiratta

Hussein

Nasser

et al. 2019

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that by 2040, neurodegenerative diseases will surpass cancer as the second reason of death after cardiovascular diseases in such aged populations. [1,2] As per a 2017 report, neurological diseases cost the United States of America about $800 billion annually and this number is expected to increase even further over the coming years as the percentage of aged citizens increases. [3] Unlike most other major diseases, the pace of drug development and delivery in case of neurodegenerative diseases has been stationary, partially due to lack of biomarkers that can diagnose such diseases long before the neurological symptoms arise and the challenges associated with identification of targets for drugs that can terminate or minimize neurodegeneration. Most importantly, delivering new cerebral therapeutic agents is impeded by the extensive and robust blood-brain barrier (BBB) which prevents the vast majority of drugs from crossing to the brain after systemic administration. During brain infections, intracerebral hemorrhage, or in neurodegenerative disorders, the BBB is altered in such a way that it allows easy access of inflammatory inducing molecules that may cause adverse neuronal damage. [4] Given the importance of early diagnosis and treatment of neurodegenerative diseases, new drug delivery technologies have appeared in the last decade.As shown in Scheme 1, unique nanomaterials have been reported and several nanosized drug delivery systems including liposomes, dendrimers, carbon nanotubes (CNTs), inorganic and hybrid nanoparticles, and polymeric micelles have gained attention and have been tested for targeted drug delivery not only for neurodegenerative diseases but also for several other ailments. [5][6][7][8][9][10] The discovery of MCM-41 was recognized as a major breakthrough in materials science and since then mesoporous silica nanoparticles (MSNs), thanks to their superior physiochemical properties such as large porosity, high surface areas, low toxicity, controllable sizes, and wide range of morphologies compared to conventional nanoparticles (NPs) have emerged as favorable tools in biomedical applications as nanocarriers for encapsulation and delivery of therapeutic medicines. [11][12][13][14] Designing biocompatible MSNs and their multifunctional derivatives for drug transport as well as theranostics is one of the hottest areas of research in the field of nanobiotechnology and nanomedicine. [15][16][17][18][19] High loading capacity, acceptable biocompatibility, and limitless possibilities of surface functionalization for specific cellular recognition Mesoporous silica nanoparticles (MSNs) have gained wide attention for their role in biomedicine and as drug delivery vehicles. Their structural tunability, high surface area, and easy functionalization impart significant advantages over conventional materials. In this Review, recent advances in the synthesis, drug delivery, and therapeutic roles of MSNs in the treatment of various neurodegenerative and neuroinflammatory diseases are presented. The intention is to...

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Section: Applications Of Msnsmentioning

confidence: 99%

Multidisciplinary Role of Mesoporous Silica Nanoparticles in Brain Regeneration and Cancers: From Crossing the Blood–Brain Barrier to Treatment

Mendiratta

Hussein

Nasser

et al. 2019

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“…The polymer shells can provide colloidal stability, handle for chemoligation (targeting moieties) and improve the blood circulation lifetimes, which are crucial for efficient in vivo drug delivery. Various polymers have been reported as coating shells poly(L-lysine) (PLL), 22 poly(N-isopropylacrylamide), 23 poly (lactic acid) (PLA) 24 either in their native forms or as conjugates. However, the applicability of these functionalized MSNs is largely restricted to their compositions and the coating materials, whereby the loading efficiency is usually not high enough for a practical usage and the polymer shell also limits both drug loading and release from MSNs.…”

Section: Introductionmentioning

confidence: 99%

Chondroitin sulfate functionalized mesostructured silica nanoparticles as biocompatible carriers for drug delivery

Qin²,

Fan³

2012

IJN

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Mesoporous silica nanoparticles (MSNs) have garnered a great deal of attention as potential carriers for therapeutic payloads. Here, we report a pH-responsive drug-carrier based on chondroitin sulfate functionalized mesostructured silica nanoparticles (NMChS-MSNs) ie, the amidation between NMChS macromer and amino group functionalized MSNs. The prepared nanoparticles were characterized using dynamic light scattering, fourier transform infrared spectroscopy and transmission electron microscopy. The resultant NMChS-MSNs were uniform spherical nanoparticles with a mean diameter of approximately 74 nm. Due to the covalent graft of hydrophilic and pH responsive NMChS, the NMChS-MSNs could be well dispersed in aqueous solution, which is favorable to being utilized as drug carriers to construct a pH-responsive controlled drug delivery system. Doxorubicin hydrochloride (DOX), a well-known anticancer drug, could be effectively loaded into the channels of NMChS-MSNs through electrostatic interactions between drug and matrix. The drug release rate of DOX@NMChS-MSNs was pH dependent and increased with the decrease of pH. The in vitro cytotoxicity test indicated that NMChS-MSNs were highly biocompatible and suitable to use as drug carriers. Our results imply that chondroitin sulfate functionalized nanoparticles are promising platforms to construct the pH-responsive controlled drug delivery systems for cancer therapy.

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“…When the unmodified silica‐based materials are used, the appearance of initial burst release of the drug is quite obvious, and in some cases, an irregular and unexpected pattern of drug release is also observed 5, 11, 34, 35. The silica‐based materials modified by the biopolymers or surfactants showed some degree of control in their initial burst release of the drugs with controllable release pattern in an extended period of time 5, 16, 26, 36–39.…”

Section: Future Perspectivesmentioning

confidence: 99%

The Silica‐based Formulations for Drug Delivery, Bone Treatment, and Bone Regeneration

Chowdhury

2016

ChemBioEng Reviews

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The utilization of the silica-based materials in biomedical applications is evolving at a rapid pace with attentions mostly devoted to the ordered mesoporous silica nanoparticles (MSNs). However, apart from the ordered-MSNs, a range of other silicabased materials have been extensively applied in the controlled release (CR) of drugs, bone treatments, and bone regeneration, but have gained less attention. This article presents an overview on the recent research advancements of the silica-based materials, i.e., silica xerogels, silica microspheres, silica hybrids, silica microcapsule particles, silica ceramics, silica bioactive glasses, and silica beads which are mainly used in CR of drugs, bone disease treatments, and bone regeneration. The in vitro and in vivo biological evaluations on these silica-based materials for antibacterial properties, osteoblast cell activities, osteogenetic performances, cell adhesion and proliferation, bio-mineralization, and material degradation are discussed. The effect of morphology or surface modifications and addition of bone morphogenetic proteins to the silica-based formulations are illustrated.

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Poly(lactic acid)-coated mesoporous silica nanosphere for controlled release of venlafaxine

Cited by 43 publications

References 34 publications

Multidisciplinary Role of Mesoporous Silica Nanoparticles in Brain Regeneration and Cancers: From Crossing the Blood–Brain Barrier to Treatment

Multidisciplinary Role of Mesoporous Silica Nanoparticles in Brain Regeneration and Cancers: From Crossing the Blood–Brain Barrier to Treatment

Chondroitin sulfate functionalized mesostructured silica nanoparticles as biocompatible carriers for drug delivery

The Silica‐based Formulations for Drug Delivery, Bone Treatment, and Bone Regeneration

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