Poly(lactic acid) porous scaffold with calcium phosphate mineralized surface and bone marrow mesenchymal stem cell growth and differentiation

Optimization of poly(ε‐caprolactone) surface properties for apatite formation and improved osteogenic stimulation

“…These materials have been used clinically as important bone‐repairing materials, and the presence of crystalline apatite or its components appear to be highly beneficial for bone tissues to bond to artificial materials 8–10. Therefore, biodegradable polymer such as PCL, coated with a bone‐like apatite layer on its surface has great potential to be used as a bone‐repairing materials since it exhibits not only improved mechanical properties but also enhanced bioactivity 10–16. In addition, the acidic effects of the degradation products of the polymers would tend to be neutralized by the presence of the apatite particles 17.…”

Effect of calcium phosphate coating and rhBMP-2 on bone regeneration in rabbit calvaria using poly(propylene fumarate) scaffolds

“…33 The aim of this study was to evaluate the role of calcium phosphate coating and simultaneous delivery 34 of recombinant human bone morphogenetic protein-2 (rhBMP-2) on the in vivo bone regeneration capa- 35 city of biodegradable, porous poly(propylene fumarate) (PPF) scaffolds. PPF scaffolds were coated with 36 three different calcium phosphate formulations: magnesium-substituted b-tricalcium phosphate 37 (b-TCMP), carbonated hydroxyapatite (synthetic bone mineral, SBM) and biphasic calcium phosphate 38 (BCP).…”

Providing osteogenesis conditions to mesenchymal stem cells using bioactive nanocomposite bone scaffolds

“…In terms of the scaffold fabrication, the involvement of the bioactive nanocomponent within PLA matrix was shown to maintain the 3D porous scaffold morphology in a fashion similar to that of the pure PLA scaffold through the freeze-drying and salt impregnation-and-leaching processes [22]. This was primarily possible due to the nanofibrous component of the glass being soaked easily in the solvents used to dissolve the PLA, which facilitated the intermixing of the PLA polymer phase within the interspaced microporous channels of the nanofibrous network without being phase-separated (Fig.…”