Poly(lactic acid)/Zinc/Alginate Complex Material: Preparation and Antimicrobial Properties

Abstract

The aim of this study was to investigate an antimicrobial and degradable composite material consisting of melt-blown poly(lactic acid) nonwoven fabrics, alginate, and zinc. This paper describes the method of preparation and the characterization of the physicochemical and antimicrobial properties of the new fibrous composite material. The procedure consists of fabrication of nonwoven fabric and two steps of dip-coating modification: (1) impregnation of nonwoven samples in the solution of alginic sodium salt and (2) immersion in a solution of zinc (II) chloride. The characterization and analysis of new material included scanning electron microscopy (SEM), specific surface area (SSA), and total/average pore volume (BET). The polylactide/alginate/Zn fibrous composite were subjected to microbial activity tests against colonies of Gram-positive (Staphylococcus aureus), Gram-negative (Escherichia coli) bacterial strains, and the following fungal strains: Aspergillus niger van Tieghem and Chaetomium globosum. These results lay a technical foundation for the development and potential application of new composite as an antibacterial/antifungal material in biomedical areas.

Activity in the Field of Blood Coagulation Processes of Poly(Lactide)-Zinc Fiber Composite Material Obtained by Magnetron Sputtering

“…The determination of the zinc content in the PLA-Zn composites was performed by prior sample mineralization (Figure 1), using a single-module Magnum II microwave mineralizer from Ertec (Wroclaw, Poland), in a similar way as was described previously [49][50][51][52][53][54]. The concentration of zinc in the obtained composites was determined by means of a Thermo Solar M6 (Thermo Scientific, LabWrench, Midland, ON, Canada) atomic absorption spectrometer and a Magnum II single-module microwave mineralizer (Ertec, Wroclaw, Poland).…”

“…The current study is a continuation of our research program aimed at developing antibacterial polymer-metal composites [49][50][51][52][53][54] and is focused on the PLA-Zn composites made from a matrix with hemostatic properties [35][36][37][38][39][40] (but without an inherent antibacterial effect [55]) and with an antipathogenic (antibacterial [56][57][58][59][60][61][62][63][64][65]; antiviral [66][67][68][69][70][71][72][73][74][75][76][77]; and antifungal [78][79][80][81][82][83][84][85][86][87]), hemostatic [88][89][90]…”

Biodegradable Nonwoven Materials with Antipathogenic Layer

“…Nonwovens made of biopolymers produced in the melting technology are a good textile base for the application of various types of active layers. Antibacterial substances are usually applied to the non-woven base, e.g., fosfonomycin [46], copper silicate [47], Ag nanoparticle [48], heterocyclic Nhalamine acetate homopolymer [49], zinc [50]. Due to the SARS-CoV-2 pandemic, biodegradable nonwovens with antiviral properties are also currently under research [51][52][53][54].…”

Degradable Poly(butylene-co-divanillyl adipate) with Intrinsic Free Radical Scavenging and Antibacterial Performance

“…coli) and had good biocompatibility with neat chitosan. However, with the slow release and migration of antibacterial agents, the antibacterial ability of the material decreases or even disappears over time, and it does not have long-term antibacterial ability. − Meanwhile, inorganic antibacterial agents have a certain biological toxicity, which limits their application fields …”