Poly(lactic-<i>co</i>-glycolic acid) encapsulated platinum nanoparticles for cancer treatment

Ruiz, Aida López; Arribas, Evaristo Villaseco; McEnnis, Kathleen

doi:10.1039/d1ma01155c

Cited by 7 publications

(3 citation statements)

References 66 publications

(86 reference statements)

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“…Encouraged by the results and previous experience, we further tested whether the partial platinum coating would influence cell viability and microrobot uptake in cells . Furthermore, based on previously published studies, it was expected that fueled microrobots would be more likely to target, enter, and accumulate within the cells in comparison to static microparticles. , Prior to these studies, possible limitations were considered.…”

Section: Resultsmentioning

confidence: 99%

Hydrogen Bonding Nanoarchitectonics of Organic Pigment-Based Janus Microrobots with Entering Capability into Cancer Cells

et al. 2022

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Autonomous microrobots are at the forefront of biomedical research as they are expected to be applied for specific tasks at the intracellular level such as cargo delivery, sensing, molecular manipulation, among others. Here, we report on a preparation of microrobots based on quinacridone and indigo, which are members of the organic hydrogen-bonded pigment family. The microrobots were fabricated by asymmetric platinum deposition on corresponding quinacridone and indigo microparticles that possessed a homogeneous size and shape distribution. The microrobots exhibited autonomous locomotion in the presence of hydrogen peroxide, which was further supported by UV irradiation. The organic pigment-based microrobots were studied in the presence of mouse colorectal carcinoma cells, and it was observed that they were internalized into the cells. Internalization was visualized using confocal laser scanning microscopy. This study reveals the possibility of fabricating hydrogen-bonded organic pigment-based microrobots for biomedical applications by employing the principles of nanoarchitectonics.

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Section: Resultsmentioning

confidence: 99%

Hydrogen Bonding Nanoarchitectonics of Organic Pigment-Based Janus Microrobots with Entering Capability into Cancer Cells

et al. 2022

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“…Again, biofabricated platinum NPs are biocompatible and have catalytic and anticancer activity [ 167 , 300 ]. In another study, researchers found that poly(lactic- co -glycolic acid) and polyethylene glycol-modified platinum NPs loaded with anti-EGFR showed better efficacy in triple-negative breast cancer [ 302 ]. Furthermore, porous Au–Pt NPs loaded with doxorubicin modified with c-RGD exhibit better drug release patterns and enhanced anticancer properties via photo-induced and photothermal processes.…”

Section: Novel Nanocarriers Based Treatment Approachmentioning

confidence: 99%

Adjuvant Novel Nanocarrier-Based Targeted Therapy for Lung Cancer

Sarma,

Akther,

Ahmad

et al. 2024

Molecules

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Lung cancer has the lowest survival rate due to its late-stage diagnosis, poor prognosis, and intra-tumoral heterogeneity. These factors decrease the effectiveness of treatment. They release chemokines and cytokines from the tumor microenvironment (TME). To improve the effectiveness of treatment, researchers emphasize personalized adjuvant therapies along with conventional ones. Targeted chemotherapeutic drug delivery systems and specific pathway-blocking agents using nanocarriers are a few of them. This study explored the nanocarrier roles and strategies to improve the treatment profile’s effectiveness by striving for TME. A biofunctionalized nanocarrier stimulates biosystem interaction, cellular uptake, immune system escape, and vascular changes for penetration into the TME. Inorganic metal compounds scavenge reactive oxygen species (ROS) through their photothermal effect. Stroma, hypoxia, pH, and immunity-modulating agents conjugated or modified nanocarriers co-administered with pathway-blocking or condition-modulating agents can regulate extracellular matrix (ECM), Cancer-associated fibroblasts (CAF),Tyro3, Axl, and Mertk receptors (TAM) regulation, regulatory T-cell (Treg) inhibition, and myeloid-derived suppressor cells (MDSC) inhibition. Again, biomimetic conjugation or the surface modification of nanocarriers using ligands can enhance active targeting efficacy by bypassing the TME. A carrier system with biofunctionalized inorganic metal compounds and organic compound complex-loaded drugs is convenient for NSCLC-targeted therapy.

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“…Metal nanoparticles (NPs) have been extensively studied due to their distinct and diverse electronic, optical, catalytic, and magnetic properties as compared to their bulk counterparts, which has led to a broad range of applications. , For example, platinum (Pt) NPs have attracted considerable attention in areas of electrocatalysis in fuel cells, , sensing, cancer treatment, chemical recycling of plastics, and catalysis for the chemical vapor deposition growth of semiconductor nanowires . The properties and activity of functional metal NPs depend strongly on their size and shape. , The effect of NP size and shape on the localized surface plasmon resonance (LSPR) of noble metal NPs such as Au , and Ag , is well documented.…”

Section: Introductionmentioning

confidence: 99%

Fabrication of Platinum Nanoparticles with Different Morphologies by Thermal Dewetting in the Presence of Residual Oxygen and Their Optical Properties

Ly,

Burns,

Cordoba

et al. 2023

J. Phys. Chem. C

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Poly(lactic-co-glycolic acid) encapsulated platinum nanoparticles for cancer treatment

Abstract: Metal nanoparticles have been of interest to the field of nanomedicine due to their potential for cancer treatment, diagnosis, and antimicrobial activity. Particularly, platinum nanoparticles (PtNPs) have been reported to...

Cited by 7 publications

References 66 publications

Hydrogen Bonding Nanoarchitectonics of Organic Pigment-Based Janus Microrobots with Entering Capability into Cancer Cells

Hydrogen Bonding Nanoarchitectonics of Organic Pigment-Based Janus Microrobots with Entering Capability into Cancer Cells

Adjuvant Novel Nanocarrier-Based Targeted Therapy for Lung Cancer

Fabrication of Platinum Nanoparticles with Different Morphologies by Thermal Dewetting in the Presence of Residual Oxygen and Their Optical Properties

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