Poly(methylmethacrylate)‐poly(vinyl pyrrolidone) microspheres as drug delivery systems: Indomethacin/cefadroxil loading and in vitro release study

Abstract

Poly(methylmethacrylate)-poly(vinyl pyrrolidone) (PMMA-PVP) microspheres loaded with cefadroxil (water-soluble) and indomethacin (water-insoluble) drugs have been prepared by the dispersion polymerization technique using PVP as a steric stabilizer. Microspheres have been characterized by differential scanning calorimetry (DSC), scanning electron microscopy (SEM) and X-ray diffraction (X-RD) studies. DSC studies indicated coating of PVP onto PMMA microspheres. SEM suggested the formation of microspheres in the size of around 5 mm. X-RD confirmed that drug has been highly dispersed in polymer particles. Higher encapsulation efficiency of up to 84% was achieved for hydrophobic drug, indomethacin than for hydrophilic cefadroxil. In vitro release studies performed in pH 7.4 phosphate buffer saline indicated that release of indomethacin was controlled up to 12 h, whereas cefadroxil was released in a controlled manner up to 10 h. During in vitro release, properties of both the drugs remained unaltered.

Material encapsulation in poly(methyl methacrylate) shell: A review

“…In some research studies, the effect of PMMA hydrophilicity on drug release from the capsules has been studied. It is found that the increasing of polymer hydrophilicity by formulating PMMA with hydrophilic polymers, improves the drug release …”

Novel pH-sensitive blend microspheres for controlled release of nifedipine – An antihypertensive drug

“…DSC thermograms of graft copolymers, plain NFD, placebo microspheres, NFD-loaded microspheres and NaAlg coated microspheres were all recorded on a Rheometric Scientific, Model DSC-SP, UK in the temperature range of 25-400 • C at the heating rate of 10 • C/min under an inert nitrogen atmosphere [21].…”

Controlled surface trap state photoluminescence from CdS QDs impregnated in poly(methyl methacrylate)

“…50 The intensity and bandwidth of CdS fluorescent bands are related to the size and the nature of carrier trap states located at the surface of the nanocrystals. 21 An emission band broadening may be considered as an effect of the change of surface environment and the change in particle size when CdS nanocrystallites are embedded in PMMA matrix. 21 In our present experimental conditions we observed the wide yellow emission profile of all samples centered at around 540-610 nm and can be considered as surface trapped induced emission, 24 i.e.…”

“…17 Poly (methyl methacrylate) [PMMA] is an important polymer which has exhibited the property of biocompatibility 18,19 and it has been used for drug delivery. 20,21 We have reported the size-selective photoluminescence 22 and anomalous photocurrent behaviour 23 for PMMA-Ag nanocrystals. To study the optical and electrical properties, in our laboratory a program was taken for the preparation of CdS QDs with different capping agents, 4,[24][25][26] QDs-polymer nanocomposites 22,23 and organic-inorganic nanocomposites for application in photodetectors.…”