Poly(N-isopropylacrylamide-co-acrylic acid) nanogels for tracing and delivering genes to human mesenchymal stem cells

Thermo-responsive polymeric nanoparticles for enhancing neuronal differentiation of human induced pluripotent stem cells

“…ACCEPTED MANUSCRIPT 20 phase transition induced a deswelling of PCANs (Figure 1D), leading to RA release from PCANs in a temperature-dependent manner ( Figure 1E). neural stem cells.…”

“…For instance, the self-assembled PNIPAM-co-acrylic acid (AA) nanogel has been used as a gene delivery carrier for human mesenchymal stem cells. 20 PNIPAM-co-AA nanogel encapsulated with PEI was internalized into human mesenchymal stem cells to release plasmid DNA within the cytosol, 20 suggesting that it could efficiently deliver specific genes into stem cells. 27,28 It has also been reported that thermo-responsive PNIPAMbased delivery systems can control the release of several growth factors.…”

“…Poly(N-isopropylacrylamide) (PNIPAM), one of the representative thermoresponsive polymers, has been applied in various forms of nanogels, injectable hydrogels, particles, and surface coating films for regulating stem cell differentiation and expansion. [20][21][22][23][24][25][26] Given its thermo-responsive properties, PNIPAM-based biomaterials could be especially useful as delivery platforms to direct stem cell fate. For instance, the self-assembled PNIPAM-co-acrylic acid (AA) nanogel has been used as a gene delivery carrier for human mesenchymal stem cells.…”

‘Smart’ nanoparticles as drug delivery systems for applications in tumor therapy

“…Such volume changes usually result from hydrogen bonds and hydrophobic interactions in response to temperature changes [22]. PNIPAM and its derivatives are one sort of the most widely applicative temperatureresponsive polymers with dramatic volume changes at the LCST ( Figure 2) [12,23].…”

Hydrogel-Based Controlled Delivery Systems for Articular Cartilage Repair

“…Local gene delivery via hydrogel scaffolds has been studied through the encapsulation of naked DNA during hydrogel formation [66, 67] using synthetic polymers such as PLGA [66] or pNIPAAm [67]. Although naked DNA achieved gene expression and guided repair in vivo [76], its low gene transfer efficiency and rapid diffusion of the DNA from the hydrogel network urged searching for alternative gene delivery systems like those based on the controlled release of DNA complexed in lipoplexes or polyplexes [74].…”