Poly(N-isopropylacrylamide-co-methacrylic acid) pH/thermo-responsive porous hydrogels as self-regulated drug delivery system

Constantin, Marieta; Bucatariu, Sanda; Harabagiu, Valeria; Popescu, Irina; Ascenzi, Paolo; Fundueanu, Gheorghe

doi:10.1016/j.ejps.2014.05.005

Cited by 64 publications

(30 citation statements)

References 29 publications

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“…9 achieved better release of both MB and MO at 37 °C, which is more suitable for drug release in the human intestinal environment. Relative to some other temperature-or pH-sensitive hydrogel products, it achieved equivalent temperature sensitivity (Xu et al 2013), more excellent pH response (Xu et al 2007), and greater biodegradability (Constantin et al 2014) for the loading and release of drugs. These results suggest that the synthesized temperature/pH sensitive hydrogel No.…”

Section: Loading and Release Of Model Drugsmentioning

confidence: 99%

Temperature/pH Sensitive Cellulose-based Hydrogel: Synthesis, Characterization, Loading, and Release of Model Drugs for Potential Oral Drug Delivery

Zhou¹,

Zhu²,

Yang³

et al. 2014

BioResources

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Due to their unique physical and chemical properties, hygrogels have been applied in various industrial and agricultural fields. Biomedicine is another high value-added and attractive area for the application of hydrogels. For this reason, a novel temperature/pH sensitive cellulose based hydrogel was synthesized based on the cellulose from Phyllostachys heterocycla. Its synthesis conditions were optimized, and its loading and release capabilities for model drugs were investigated in detail. The resultant data showed that the synthesized hydrogel exhibited the highest swelling ratio at 37 °C and pH 7.4, corresponding to the temperature and pH of the human intestinal environment. The hydrogel held excellent load performance for model drug MB and an obvious temperature dependence at 37 °C (body temperature of human) when the model drug was released from it. These positive results suggest that the synthesized temperature/pH sensitive cellulose-based hydrogel has a great potential for oral drug delivery applications.

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Section: Loading and Release Of Model Drugsmentioning

confidence: 99%

Temperature/pH Sensitive Cellulose-based Hydrogel: Synthesis, Characterization, Loading, and Release of Model Drugs for Potential Oral Drug Delivery

Zhou¹,

Zhu²,

Yang³

et al. 2014

BioResources

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“…In fact, in these conditions they are stabilised by hydrogen interactions between the NIPAAm and acrylic acid blocks. NIPAAm copolymers with methacrylic acid have also been synthesized and studied for double pH and thermo-sensitive drug delivery system development [16]. The copolymer loses thermosensitivity at physiological pH and temperature and regains them when interacting with some positively charged drugs.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Investigation of Double Stimuli-Responsive Behavior ofN-Isopropylacrylamide and Maleic Acid Copolymer in Solutions

Филиппов

Тарабукина

Simonova

et al. 2015

Journal of Macromolecular Science, Part B

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Poly(N-isopropylacrylamide-co-maleic acid) (poly(NIPAAm-co-MA)) linear copolymer with comonomer molar ratio NIPAAm : MA = 94 : 6 was synthesized by free radical copolymerization. The molar mass, M sD = 28000 Da, of poly(NIPAAm-co-MA) was determined using hydrodynamic methods. The self-assembly of poly(NIPAAm-co-MA) in aqueous solution at a concentration of 0.015 g cm -3 within the pH interval from 1.8 to 10.6 and the temperature interval from 22 to 60 °C was investigated by static and dynamic light scattering. The copolymer showed a double temperature and pH responsiveness. Three types of particles, namely, macromolecules (or unimers), micellar-like structures, and loose aggregates existed in the Downloaded by [New York University] at 23:31 11 June 2015 ACCEPTED MANUSCRIPT ACCEPTED MANUSCRIPT 2 poly(NIPAAm-co-MA) aqueous solutions. The fraction of dissolved entities and the hydrodynamic radii of the micellar-like structures and loose aggregates depended considerably on temperature and pH. The temperature of the phase separation and the width of the phase separation interval increased with pH. An influence of pH on kinetic processes in poly(NIPAAm-co-MA) solutions was observed.

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“…Due to its chemical functionalities (ionizable NH 2 groups), CHIT confers pH responsivity when inserted into hydrogel networks . On the other hand, the simultaneous employment of functional monomers (e.g., N ‐isopropylacrylamide (NIPAAm)) was proved to be a valuable strategy to introduce thermoresponsivity to the whole system, with the obtainment of dual‐sensitive materials …”

Section: Introductionmentioning

confidence: 99%

Chitosan–Quercetin Bioconjugate as Multi‐Functional Component of Antioxidants and Dual‐Responsive Hydrogel Networks

Cirillo

Curcio

Spizzirri

et al. 2019

Macro Materials & Eng

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Multifunctional hydrogels based on chitosan–quercetin (CHITQ) conjugate are prepared by a thermo‐induced radical procedure in the presence of N‐isopropylacrylamide (NIPAAm), acrylamide (AAm), and N,N′‐methylenebis(acrylamide) (MEBA). At first, quercetin (Q) is grafted onto chitosan backbone with a functionalization degree of 275 mg of Q per gram of conjugate, as calculated by 1H‐NMR analyses to impart antioxidant properties to the polysaccharide. Then, a pH and temperature sensitive hydrogel was obtained by involving CHITQ and NIPAAm in the polymerization reaction. The accessibility of phenolic moieties is modified in response to the hydrogel swelling/deswelling, as confirmed by antioxidant tests performed at different temperatures. Dual stimuli‐responsive hydrogels are proposed for the delivery of caffeine as model drug. The release profiles of caffeine depict a system particularly performing as on/off device at acidic pH with excellent applicability prospects.

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Poly(N-isopropylacrylamide-co-methacrylic acid) pH/thermo-responsive porous hydrogels as self-regulated drug delivery system

Cited by 64 publications

References 29 publications

Temperature/pH Sensitive Cellulose-based Hydrogel: Synthesis, Characterization, Loading, and Release of Model Drugs for Potential Oral Drug Delivery

Temperature/pH Sensitive Cellulose-based Hydrogel: Synthesis, Characterization, Loading, and Release of Model Drugs for Potential Oral Drug Delivery

Synthesis and Investigation of Double Stimuli-Responsive Behavior ofN-Isopropylacrylamide and Maleic Acid Copolymer in Solutions

Chitosan–Quercetin Bioconjugate as Multi‐Functional Component of Antioxidants and Dual‐Responsive Hydrogel Networks

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