Temperature/pH Sensitive Cellulose-based Hydrogel: Synthesis, Characterization, Loading, and Release of Model Drugs for Potential Oral Drug Delivery

Zhou, Huifang; Zhu, Hangcheng; Yang, Xiaogang; Zhang, Yong; Zhang, Xiumei; Cui, Kecong; Shao, Lan; Yao, Juming

doi:10.15376/biores.10.1.760-771

Cited by 15 publications

(11 citation statements)

References 21 publications

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“…Zhou et al synthesized cellulose based temperature/pH sensitive hydrogels for controlled oral drug delivery of model drug, methylene blue/methylene orange. The as-prepared hydrogels exhibited excellent pH sensitivity and showed swelling at pH 7.4 [ 90 ].…”

Section: Base Materials For Ph Sensitive Hydrogelsmentioning

confidence: 99%

pH Sensitive Hydrogels in Drug Delivery: Brief History, Properties, Swelling, and Release Mechanism, Material Selection and Applications

et al. 2017

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Improving the safety efficacy ratio of existing drugs is a current challenge to be addressed rather than the development of novel drugs which involve much expense and time. The efficacy of drugs is affected by a number of factors such as their low aqueous solubility, unequal absorption along the gastrointestinal (GI) tract, risk of degradation in the acidic milieu of the stomach, low permeation of the drugs in the upper GI tract, systematic side effects, etc. This review aims to enlighten readers on the role of pH sensitive hydrogels in drug delivery, their mechanism of action, swelling, and drug release as a function of pH change along the GI tract. The basis for the selection of materials, their structural features, physical and chemical properties, the presence of ionic pendant groups, and the influence of their pK a and pK b values on the ionization, consequent swelling, and targeted drug release are also highlighted.

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Section: Base Materials For Ph Sensitive Hydrogelsmentioning

confidence: 99%

pH Sensitive Hydrogels in Drug Delivery: Brief History, Properties, Swelling, and Release Mechanism, Material Selection and Applications

et al. 2017

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“…The release of a model molecule (dimethyl methylene blue) showed that these systems are promising smart materials for drug delivery [329]. In addition, to being thermoresponsive, NIPAAm/cellulose showed pH-responsiveness as these hydrogels showed higher water uptake capacities at alkaline pHs than at acidic pHs [330]. Bajpai et al developed a polyacrylic acid, and carboxymethyl cellulose semi interpenetrated polymer network for the controlled release of ciprofloxacine [331].…”

Section: Cellulose-based Hydrogels For Drug Deliverymentioning

confidence: 99%

Status and future scope of plant-based green hydrogels in biomedical engineering

Mohammadinejad

Maleki

Larrañeta

et al. 2019

Applied Materials Today

189

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Hydrogels are the most iconic class of soft materials and since their first report in the literature has attracted the attention of uncountable researchers. Over the past two decades, hydrogels become smart and sophisticated materials with plenty of applications possibilities. The biomedical research area has demonstrated a particular interest in hydrogels since they can be engineered from different polymers and due to their tunable properties. Moreover, hydrogels engineered from polymers extracted from biorenewable sources have been popularized in biomedical usages, as they are low-toxic, eco-friendly, biocompatible, easily accessible, and inexpensive at the same time. However, the multifaceted challenge is to find an ideal plant green hydrogel in the tissue engineering that can mimic critical properties of human tissues in terms of structure, function, and performance. In addition, these natural polymers are also idealized to be conveniently functionalized so that their chemical and physical behaviour can be manipulated for drug delivery and stem cell-guided tissue regeneration. Here, the most recent advances in the synthesis, fabrication and application of plant green hydrogels in biomedical engineering are reviewed. It covers essential and updated information about plant as green sources of biopolymers to be used in hydrogel synthesis, general aspects of hydrogels and plant green hydrogels and a substantive discussion regarding the use of such hydrogels in the biomedical engineering area. Furthermore, this review addresses and detail the present status of the field and, also, answer several important questions about the potential use of plant green hydrogels in advanced biomedical applications including therapeutic, tissue engineering, wound dressing, diagnostic, etc.

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“…Zhou et al found that cellulose extracted from bamboo (Phyllostachys heterocycla) shows high swelling rates at human body temperature and intestinal pH. Thus, hydrogels based on this cellulose exhibit an immense potential as an oral drug model [159]. According to Sannino et al, edema problems can also be treated using cellulose-based hydrogels as these systems have improved water absorbing and holding capacity [160].…”

Section: Hydrogels In Biomedicinementioning

confidence: 99%

From Cellulose Dissolution and Regeneration to Added Value Applications — Synergism Between Molecular Understanding and Material Development

Singh¹,

Duarte²,

Alves³

et al. 2015

Cellulose - Fundamental Aspects and Current Trends

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Modern society is now demanding greener materials due to depleting fossil fuels and increasing environmental awareness. In the near future, industries will need to become more resource-conscious by making greater use of available renewable and sustainable raw materials. In this context, agro-forestry and related industries can indeed contribute to solve many resource challenges for society and suppliers in the near future. Thus, cellulose can be predicted to become an important resource for materials due to its abundance and versatility as a biopolymer. Cellulose is found in many different forms and applications. However, the dissolution and regeneration of cellulose are key and challenging aspects in many potential applications. This chapter is divided into two parts i achievements in the field of dissolution and regeneration of cellulose including solvents and underlying mechanisms of dissolution and ii state-of-the-art production of value-added materials and their applications including manmade textile fibers, hydrogels, aerogels, and all-cellulose composites, where the latter is given special attention.Keywords: Cellulose, dissolution and regeneration, fiber, hydrogels, all-cellulose composites . IntroductionCellulose was isolated for the first time by the French chemist "nselme Payen in [ ], who extracted it from green plants and reported its elemental composition four years later [ ].Cellulose is the main component of the cell wall in higher plants, typically combined with © 2015 The Author(s). Licensee InTech. This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.lignin, hemicelluloses, pectins, proteins, and water. "part from higher plants, cellulose can be synthesized by bacteria or be found in algae and tunicates. This readily available and renewable biopolymer is widely used in many applications such as paper, textiles, membranes, or packaging [ ]. Cellulose is the most abundant and studied biorenewable material with an estimated annual production of . x t [ ]. "fter more than years of research into the sugar of the plant cell wall , consumers, industries, and governments are increasingly demanding products from renewable and sustainable resources that are biodegradable, nonpetroleum based, carbon neutral, and, at the same time, generating low environmental, animal/ human health and safety risks [ ].Regarding its basic structure, cellulose is a linear syndiotactic homopolymer composed of D-anhydroglucopyranose units "GU , that are connected by -glycosidic bonds Figure [ ]. The size of the cellulose molecules can be defined by the average degree of polymerization DP . The average molecular weight is estimated from the product of the DP and the molecular mass of a single "GU. Each "GU bears three hydroxyl groups one primary and two secondary moieties that represent more than % by weight , with t...

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Temperature/pH Sensitive Cellulose-based Hydrogel: Synthesis, Characterization, Loading, and Release of Model Drugs for Potential Oral Drug Delivery

Cited by 15 publications

References 21 publications

pH Sensitive Hydrogels in Drug Delivery: Brief History, Properties, Swelling, and Release Mechanism, Material Selection and Applications

pH Sensitive Hydrogels in Drug Delivery: Brief History, Properties, Swelling, and Release Mechanism, Material Selection and Applications

Status and future scope of plant-based green hydrogels in biomedical engineering

From Cellulose Dissolution and Regeneration to Added Value Applications — Synergism Between Molecular Understanding and Material Development

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