Poly(N-Vinylpyrrolidone)

Sandler, Stanley R.; Karo, Wolf

doi:10.1016/b978-0-08-092555-4.50012-8

Cited by 5 publications

(2 citation statements)

References 48 publications

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“…N ‐vinyl pyrrolidone (NVP) is the monomer being used to prepare homopolymer poly(vinyl pyrrolidone) (PVP) and copolymers with different vinyl monomers. NVP is amphiphilic in nature and can be polymerized by a variety of techniques such as free radical and solution polymerizations 1. PVP has long history of use in controlled drug delivery due to its biocompatibility, chemical stability, and excellent aqueous solubility 2, 3.…”

Section: Introductionmentioning

confidence: 99%

Release of dexamethasone from poly(N‐vinyl pyrrolidone‐co‐n‐hexyl methacrylate) copolymers of controlled hydrophilicity

Huma

Akhter

Zafar-uz-Zaman

et al. 2012

J of Applied Polymer Sci

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A copolymer system with controlled hydrophilicity has been prepared through copolymerization technique and its capability as controlled drug release carrier is investigated. The effect of copolymer composition on water uptake, thermal properties, and morphology is reported. The water uptake increases with increasing N-vinyl pyrrolidone content and diffusion of water molecules appears to be non-Fickian. Dexamethasone has been selected as model drug and its controlled release from selected water stable copolymers follows for more than 1 month. Initial burst release of more than 50% occurs in 7 days. The remaining drug is released in a sustained way upto 37 days. Initial 10 h drug release pattern involves first-order kinetics (NH73) and zero-order kinetics (NH55), whereas initial 60% drug release mechanism appears to be non-Fickian for NH73 (n ¼ 0.71) and Case II transport (n ¼ 1.24) for NH55.

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Section: Introductionmentioning

confidence: 99%

Release of dexamethasone from poly(N‐vinyl pyrrolidone‐co‐n‐hexyl methacrylate) copolymers of controlled hydrophilicity

Huma

Akhter

Zafar-uz-Zaman

et al. 2012

J of Applied Polymer Sci

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“…NVP can be polymerized by a variety of techniques such as free radical and solution polymerizations that are relevant to drug delivery and other applications. [1] In its linear form, the polymer PVP is highly soluble in water; as a crosslinked network, it is capable of imbibing very large amounts of water and is therefore quite effective as a hydrogel. A downside of the hydrophilicity of PVP is that the high absorbency of the material leads to fragile structures.…”

Section: Introductionmentioning

confidence: 99%

Molecular Structure of Physiologically‐Responsive Hydrogels Controls Diffusive Behavior

Carr

Peppas

2009

Macromolecular Bioscience

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SummaryPolymeric networks and the ensuing hydrogels of methacrylic acid and N-vinyl pyrrolidone were successfully synthesized using a UV-initiated free radical polymerization and characterized to assess their applicability as carriers for directed drug delivery. FT-IR spectroscopy revealed shifts in peak absorbances that indicated the presence of hydrogen bonding complexes between functional groups, while SEM imaging showed that the different comonomers affect the surface morphology of the microparticles. Dynamic pH swelling studies demonstrated the pH responsiveness of the carriers in gastric and intestinal conditions and revealed that systems containing higher concentrations of methacrylic acid experienced the highest degree of hydrogen bonding complexation in gastric conditions. The presence of NVP in the systems enhanced swelling. Equilibrium swelling studies revealed that the mesh size was sufficiently large to allow drug diffusion across the networks.

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Conventional Free Radical Polymerization ofN‐VinylPyrrolidone Homopolymers

Tallon¹,

Musa²

2021

Handbook of Pyrrolidone and Caprolactam Based Materials

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This chapter focuses on the synthesis of polyvinyl pyrrolidone (PVP) in a variety of forms, and describes methodologies to produce soluble, branched, and crosslinked versions. It explains critical factors involved in the conventional free‐radical polymerization processes employing thermal initiators to manufacture PVP. PVP is soluble in water and polar solvents, insoluble in esters, ethers, and hydrocarbons. There are generally two types of free‐radical initiator used commercially. These are peroxide‐based, or azo‐based. Molecular weight control over the polyvinyl pyrrolidone polymer is affected by both the initiator concentration as well as the monomer concentration. The use of a water soluble azo‐initiator in the polymerization of N‐vinyl pyrrolidone was performed using Vazo‐50 initiator. Azo‐mediated N‐vinyl pyrrolidone homopolymerization in water can be initiated by sparingly soluble to freely‐soluble azo‐initiators. A number of different approaches to reduce residual monomer levels have been applied in the production of free‐radical polymers.

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Poly(N-Vinylpyrrolidone)

Cited by 5 publications

References 48 publications

Release of dexamethasone from poly(N‐vinyl pyrrolidone‐co‐n‐hexyl methacrylate) copolymers of controlled hydrophilicity

Release of dexamethasone from poly(N‐vinyl pyrrolidone‐co‐n‐hexyl methacrylate) copolymers of controlled hydrophilicity

Molecular Structure of Physiologically‐Responsive Hydrogels Controls Diffusive Behavior

Conventional Free Radical Polymerization ofN‐VinylPyrrolidone Homopolymers

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