Poly(norepinephrine)-coated FeOOH nanoparticles as carriers of artemisinin for cancer photothermal-chemical combination therapy

Zi, He; Shen, Yuqing; Shi, Wei; Liu, Xin; Liu, Yang; Zhang, Fuhui; Zhang, Yansheng; Sun, Yanan; Ge, Dongtao

doi:10.1039/c9ra01289c

Cited by 18 publications

(8 citation statements)

References 58 publications

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“…A number of reports have demonstrated the advantages of PNE coating techniques over PDA coating, in terms of coating uniformity. Compared to that with PDA, the PNE coating provides a more uniform and well-defined nanolevel coating on the surfaces. ,, Hence, it is often recommended as a more preferable chemical approach for material surface coatings. ,, It is expected that the surface of the resulting PNE-coated nanomaterials may exhibit more reproducible and consistent characteristics in forming dynamic covalent bonds with the polymeric networks.…”

Section: Chemical Strategies: Nanocomposite Hydrogelsmentioning

confidence: 99%

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Physical and Chemical Factors Influencing the Printability of Hydrogel-based Extrusion Bioinks

et al. 2020

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Bioprinting researchers agree that “printability” is a key characteristic for bioink development, but neither the meaning of the term nor the best way to experimentally measure it has been established. Furthermore, little is known with respect to the underlying mechanisms which determine a bioink’s printability. A thorough understanding of these mechanisms is key to the intentional design of new bioinks. For the purposes of this review, the domain of printability is defined as the bioink requirements which are unique to bioprinting and occur during the printing process. Within this domain, the different aspects of printability and the factors which influence them are reviewed. The extrudability, filament classification, shape fidelity, and printing accuracy of bioinks are examined in detail with respect to their rheological properties, chemical structure, and printing parameters. These relationships are discussed and areas where further research is needed, are identified. This review serves to aid the bioink development process, which will continue to play a major role in the successes and failures of bioprinting, tissue engineering, and regenerative medicine going forward.

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Section: Chemical Strategies: Nanocomposite Hydrogelsmentioning

confidence: 99%

“…374,377,378 Hence, it is often recommended as a more preferable chemical approach for material surface coatings. 375,379,380 It is expected that the surface of the resulting PNE-coated nanomaterials may exhibit more reproducible and consistent characteristics in forming dynamic covalent bonds with the polymeric networks.…”

Section: Nanocarbon-based Hydrogelsmentioning

confidence: 99%

Physical and Chemical Factors Influencing the Printability of Hydrogel-based Extrusion Bioinks

et al. 2020

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“…For example, the pH-responsive DHA-GO-TF and TF-8arm-PEG-DHA delivery systems both showed higher solubility, enhanced tumor delivery specificity, minimal side-effects, and superior tumor growth restrained ability in vivo [184,185]. Third, the release of metal ions by polymer-based nanoparticles was shown to enhance ART or ART derivative-induced tumor inhibition [187][188][189].…”

Section: Polymer-based Art-loaded Nanoparticlesmentioning

confidence: 99%

Artemisinin-Type Drugs in Tumor Cell Death: Mechanisms, Combination Treatment with Biologics and Nanoparticle Delivery

et al. 2022

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Artemisinin, the most famous anti-malaria drug initially extracted from Artemisia annua L., also exhibits anti-tumor properties in vivo and in vitro. To improve its solubility and bioavailability, multiple derivatives have been synthesized. However, to reveal the anti-tumor mechanism and improve the efficacy of these artemisinin-type drugs, studies have been conducted in recent years. In this review, we first provide an overview of the effect of artemisinin-type drugs on the regulated cell death pathways, which may uncover novel therapeutic approaches. Then, to overcome the shortcomings of artemisinin-type drugs, we summarize the recent advances in two different therapeutic approaches, namely the combination therapy with biologics influencing regulated cell death, and the use of nanocarriers as drug delivery systems. For the former approach, we discuss the superiority of combination treatments compared to monotherapy in tumor cells based on their effects on regulated cell death. For the latter approach, we give a systematic overview of nanocarrier design principles used to deliver artemisinin-type drugs, including inorganic-based nanoparticles, liposomes, micelles, polymer-based nanoparticles, carbon-based nanoparticles, nanostructured lipid carriers and niosomes. Both approaches have yielded promising findings in vitro and in vivo, providing a strong scientific basis for further study and upcoming clinical trials.

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“…In vivo evidence showed that the anticancer efficacy of DHA@HPDA-Fe was 3.05 times higher compared with free DHA (Dong et al, 2019). Besides, some other biocompatible polyphenolic compounds such as tannic acid have similar binding and releasing futures toward Fe 2+ and Fe 3+ (Kell, 2009;Du et al, 2019;He et al, 2019). These polymers could also be considered for construction of ART's nanotherapeutics, but the related research is still rare.…”

Section: Iron-containing Soft Matters For Arts Delivery and Activationmentioning

confidence: 99%

Recent Progresses in Cancer Nanotherapeutics Design Using Artemisinins as Free Radical Precursors

Zeng

et al. 2020

Front. Chem.

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Artemisinin and its derivatives (ARTs) are sort of important antimalarials, which exhibit a wide range of biological activities including anticancer effect. To solve the issues regarding poor solubility and limited bioavailability of ARTs, nanoformulation of ARTs has thus emerged as a promising strategy for cancer treatment. A common consideration on nanoARTs design lies on ARTs' delivery and controlled release, where ARTs are commonly regarded as hydrophobic drugs. Based on the mechanism that ARTs' activation relies on ferrous ions (Fe 2+ ) or Fe 2+ -bonded complexes, new designs to enhance ARTs' activation have thus attracted great interests for advanced cancer nanotherapy. Among these developments, the design of a nanoparticle that can accelerate ARTs' activation has become the major consideration, where ARTs have been regarded as radical precursors. This review mainly focused on the most recent developments of ARTs nanotherapeutics on the basis of advanced drug activation. The basic principles in those designs will be summarized, and a few excellent cases will be also discussed in detail.

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Poly(norepinephrine)-coated FeOOH nanoparticles as carriers of artemisinin for cancer photothermal-chemical combination therapy

Abstract: Tumor-specific FeOOH@PNE-Art nanoparticles were fabricated that showed high efficacy of photothermal-chemical combination therapy and low toxicity to normal tissue.

Cited by 18 publications

References 58 publications

Physical and Chemical Factors Influencing the Printability of Hydrogel-based Extrusion Bioinks

Physical and Chemical Factors Influencing the Printability of Hydrogel-based Extrusion Bioinks

Artemisinin-Type Drugs in Tumor Cell Death: Mechanisms, Combination Treatment with Biologics and Nanoparticle Delivery

Recent Progresses in Cancer Nanotherapeutics Design Using Artemisinins as Free Radical Precursors

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