Poly-phosphocholination of liposomes leads to highly-extended retention time in mice joints

Lin, Weifeng; Goldberg, Ronit; Klein, Jacob

doi:10.1039/d1tb02346b

Cited by 25 publications

(15 citation statements)

References 69 publications

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“…For example, Lipotalon® (Merckle, Germany) is the first used liposome formulation in Germany to clinically treat OA by IA delivery, 43 containing dexamethasone palmitate as active ingredient, preferentially taken up by synovial macrophages after IA injection and transformed to its active form by intracellular esterases, thus preventing the side effects of free dexamethasone (synovitis and tissue irritation). 99 , 100 …”

Section: Different Drug-delivery Systems For Intra-articular Injectio...mentioning

confidence: 99%

Knee Osteoarthritis Therapy: Recent Advances in Intra-Articular Drug Delivery Systems

Ma¹,

Zheng²,

Li³

et al. 2022

DDDT

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Drug delivery for osteoarthritis (OA) treatment is a continuous challenge because of their poor bioavailability and rapid clearance in joints. Intra-articular (IA) drug delivery is a common strategy and its therapeutic effects depend mainly on the efficacy of the drug-delivery system used for OA therapy. Different types of IA drug-delivery systems, such as microspheres, nanoparticles, and hydrogels, have been rapidly developed over the past decade to improve their therapeutic effects. With the continuous advancement in OA mechanism research, new drugs targeting specific cell/signaling pathways in OA are rapidly evolving and effective drug delivery is critical for treating OA. In this review, recent advances in various IA drug-delivery systems for OA treatment, OA targeted strategies, and related signaling pathways in OA treatment are summarized and analyzed based on current publications.

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Section: Different Drug-delivery Systems For Intra-articular Injectio...mentioning

confidence: 99%

Knee Osteoarthritis Therapy: Recent Advances in Intra-Articular Drug Delivery Systems

Ma¹,

Zheng²,

Li³

et al. 2022

DDDT

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“…Although liposomes offer several advantages over other carrier systems, such as the ability to carry both hydrophobic and hydrophilic compounds, high encapsulation efficiency, biocompatibility, and transport ability through cell membranes, they are thermodynamically unstable systems prone to aggregation, fusion, degradation, or hydrolyzation, resulting in leakage of the entrapped compounds. The main limitations of liposome application in drug delivery systems are their physical and chemical instability [ 20 , 21 ] and their retention time after both systemic and local application [ 22 ]. Hydrophobic interactions are responsible for their physical instability, while degradative lipid oxidation determines their chemical instability.…”

Section: Introductionmentioning

confidence: 99%

Biopolymer Lipid Hybrid Microcarrier for Transmembrane Inner Ear Delivery of Dexamethasone

Dindelegan

Paşcalău

Suciu

et al. 2022

Gels

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Dexamethasone is one of the most often used corticosteroid drugs for sensorineural hearing loss treatment, and is used either by intratympanic injection or through systemic delivery. In this study, a biopolymer lipid hybrid microcarrier was investigated for enhanced local drug delivery and sustained release at the round window membrane level of the middle ear for the treatment of sensorineural hearing loss (SNHL). Dexamethasone-loaded and dexamethasone-free microparticles were prepared using biopolymers (polysaccharide and protein, pectin and bovine serum albumin, respectively) combined with lipid components (phosphatidylcholine and Dimethyldioctadecylammonium bromide) in order to obtain a biopolymer–liposome hybrid system, with a complex structure combining to enhance performance in terms of physical and chemical stability. The structure of the microparticles was evaluated by FTIR, XRD, thermal analysis, optical microscopy, and scanning electron microscopy (SEM). The encapsulation efficiency determination and the in vitro Dexamethasone release study were performed using UV-Vis spectroscopy. The high value of encapsulation efficiency and the results of the release study indicated six days of sustained release, encouraging us to evaluate the in vitro cytotoxicity of Dexamethasone-loaded microparticles and their influence on the cytotoxicity induced by Cisplatin on auditory HEI-OC1 cells. The results show that the new particles are able to protect the inner ear sensory cells.

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“…It was also found that such PMPCylated liposomes intra-articularly (IA) injected into mice joints showed a significant increase in retention half-life compared with PEGylated liposomes. [44] In order to reduce friction between surfaces, the liposomes must adsorb on the substrate to form boundary layers. Non-functionalized PC liposomes adsorb on negatively charged surfaces via dipole-charge interactions between the phosphocholine zwitterions and the negative surface charges.…”

Section: Introductionmentioning

confidence: 99%

Neutral polyphosphocholine-modified liposomes as boundary superlubricants

Lin

Kampf

Klein

2022

Colloids and Surfaces A: Physicochemical and Engineering Aspect

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Poly-phosphocholination of liposomes leads to highly-extended retention time in mice joints

Abstract: Surface-attached layers of phosphatidylcholine (PC) lipid vesicles (liposomes) may reduce the friction coefficient μ (= force-to-slide/load) between the sliding surfaces down to μ ≈ 10-3 – 10-4 up to tens...

Cited by 25 publications

References 69 publications

Knee Osteoarthritis Therapy: Recent Advances in Intra-Articular Drug Delivery Systems

Knee Osteoarthritis Therapy: Recent Advances in Intra-Articular Drug Delivery Systems

Biopolymer Lipid Hybrid Microcarrier for Transmembrane Inner Ear Delivery of Dexamethasone

Neutral polyphosphocholine-modified liposomes as boundary superlubricants

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