Poly(styrenesulfonate)-Modified Ni–Ti Layered Double Hydroxide Film: A Smart Drug-Eluting Platform

Abstract

Drug-eluting stents (DESs) are widely used in the palliative treatment of many kinds of cancers. However, the covered polymers used in DESs are usually associated with stent migration and acute cholecystitis. Therefore, developing noncovered drug-loading layers on metal stents is of great importance. In this work, Ni-Ti layered double hydroxide (Ni-Ti LDH) films were prepared on the surface of nitinol via hydrothermal treatment, and the LDH films were further modified by poly(styrenesulfonate) (PSS). The anticancer drug doxorubicin could be effectively loaded onto the modified films, and drug release could be smartly controlled by the pH. Besides, the drug absorption amounts of cancer cells cultured on the films could be effectively improved. These results indicate that the PSS-modified LDH film may become a promising drug-loading platform that can be used in the design of DESs.

Effect of Polyelectrolyte Mono- and Bilayer Formation on the Colloidal Stability of Layered Double Hydroxide Nanoparticles

“…Polymer-modified LDH-PSS multilayered films showed excellent oxygen barrier performance with self-healing ability [30]. LDH films were prepared in a hydrothermal process and modified with PSS to achieve higher drug loading ability [31]. The drug release could be smartly controlled from the obtained hybrid materials.…”

NIR‐Triggered Crystal Phase Transformation of NiTi‐Layered Double Hydroxides Films for Localized Chemothermal Tumor Therapy

“…Recently, layered double hydroxides (LDHs) are widely investigated as drug carriers owning to their high biocompatibility and ion exchange capacities . In addition, LDHs films can be easily grown on many kinds of biomedical metals, such as magnesium and its alloys, titanium and nitinol, making them suitable for surface drug‐loading layers construction on biomedical implants . However, few studies focus on the temperature sensitivities of LDHs materials, which may be used in the preparation of stimuli‐responsive drug‐eluting platforms.…”

Layered double hydroxide-based nanomaterials for biomedical applications

“…To further improve the DOX absorption ability of cancer cells, Ge et al prepared electronegative poly(styrenesulfonate) (PSS)-modified NiTi-LDH to load DOX by physical mixing at 37 1C. 248 DOX could be internalized by cancer cells through endocytosis rather than passive diffusion with the assistance of PSS, thereby enhancing drug absorption. Li et al designed a hyaluronidase (HAase)-modified MgAl-LDH nanoplatform to physically load DOX (DOX/LDH-HAase) for enhanced tumor penetration and augmented chemotherapy (Fig.…”