Poly(triazolyl methacrylate) glycopolymers as potential targeted unimolecular nanocarriers

Abstract

The ability of poly(triazolyl methacrylate) glycopolymers to function as unimolecular targeted carriers for hydrophobic guest molecules was investigated using a combination of experimental and computational techniques.

CO2-Switchable Single-Chain Polymeric Nanoparticles Enable Gas-Controllable Reaction Separation for Asymmetric Catalysis in Water

“…Fluorescence dye of Nile red was used as the hydrophobic probe to assess the presence of hydrophobic interiors in the formed PD x (IS) y -based SCPNs. 42 The original typical PD 202 (IS) 4 copolymer and Nile red dye are solid and completely insoluble in water. Upon CO 2 bubbling, the aqueous system becomes homogenous, accompanied by the increasing fluorescence emission intensity of Nile red (see the corresponding fluorescence spectroscopy spectra in Figure S7).…”

Hyaluronan (HA)-inspired glycopolymers as molecular tools for studying HA functions

“…Similar glycopolymer systems have shown to aggregate at low concentration due to collapse of the hydrophobic polymer backbone. 35 To assess the aggregation behaviour of the glycopolymers in water, fluorescence measurements were conducted using Nile red as a fluorescent reporter. Nile red is a sovatochromic dye that has very weak fluorescence intensity in pure water, with an emission maximum at around 660 nm, but when encapsulated in a hydrophobic environment, it emits strong fluorescence at around 620 nm (blue shift).…”

Starch/Poly(glycerol-adipate) Nanocomposites: A Novel Oral Drug Delivery Device

“…All atom molecular dynamics (MD) simulations are attracting attention in the polymer-based drug delivery field as a tool to enlighten the interactions taking place at an atomistic level [43][44][45]. Our 10 ns MD simulations for the interactions between the dimers of PGA and the two drugs were used to evaluate the distance between the moieties and the possible formation of hydrogen bonds.…”