2017
DOI: 10.1016/j.ijpharm.2016.10.069
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Poly vinyl acetate and ammonio methacrylate copolymer as unconventional polymer blends increase the mechanical robustness of HPMC matrix tablets

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Cited by 14 publications
(6 citation statements)
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“…Eventually, this thorough diffusion led to swelling of the polymer layer forming a high viscosity gel matrix. The presence of HPMC K4M in the swellable layer led to an increased hydration, which in turns resulted in higher swelling degree and erosion [27]. The innermost coating layer adjacent to the bilayer tablet was made of OpadryII®.…”
Section: Resultsmentioning
confidence: 99%
“…Eventually, this thorough diffusion led to swelling of the polymer layer forming a high viscosity gel matrix. The presence of HPMC K4M in the swellable layer led to an increased hydration, which in turns resulted in higher swelling degree and erosion [27]. The innermost coating layer adjacent to the bilayer tablet was made of OpadryII®.…”
Section: Resultsmentioning
confidence: 99%
“…Hydrophilic matrix tablets offer an interesting potential for oral controlled drug delivery [1,2,3,4,5,6,7]. Hydroxypropyl methylcellulose (HPMC) is frequently used for this purpose [8,9,10,11,12,13,14]. Upon administration, water penetrates into the system and dissolves the drug [15,16,17].…”
Section: Introductionmentioning
confidence: 99%
“…Polymer blends offer an interesting potential for controlled drug delivery systems [1,2,3,4,5,6], both as matrix formers [7,8,9,10] and as coating materials [11,12,13,14,15]. By simply varying the polymer:polymer blend ratio, the resulting key properties of the systems can be effectively varied, allowing to provide large spectra of possible drug release kinetics [16,17,18].…”
Section: Introductionmentioning
confidence: 99%