Poly (vinyl alcohol) functionalized by monosuccinate groups. Coupling of bioactive amino compounds

Low-Molecular-Weight Polymer–Drug Conjugates for Synergistic Anticancer Activity of Camptothecin and Doxorubicin Combinations

“…The conjugation of CPT and DOX to a low-molecular-weight 10 kDa polymer was first studied in a characteristic nonbiodegradable polymer, poly(vinyl alcohol) (PVA) with one of the most commonly-used hydrolyzable tethers, Figure 1, which resulted in 0.39 mol% CPT or 0.16 mol% DOX relative to PVA. These conjugation efficiencies are expected, since both reaction steps in Figure 1, the succinic anhydride modification of PVA and the esterification of succinic acid, are known to be thermodynamically limited [30,31]. It has been previously shown that higher CPT conjugation efficiencies, as high as 30 mol%, can be achieved if synthesis does not require prior polymer modifications and if CPT is modified to contain a more reactive amine functionality [32].…”

Bioactive and degradable organic–inorganic hybrids

“…Actually, PVAL has been widely proposed for controlled release systems due to its biodegradablity. [7][8] As far as we know, previous to our studies only one article reported the synthesis of bioactive hybrids based on PVAL-modified gel glasses, but the goal was to obtain bioactive coatings. 9 The study of this family of hybrids as monolithic pieces, seemed promising for novel clinical applications.…”

Grafting of copolymer styrene maleic anhydride on poly(ethylene terephthalate) film by chemical reaction and by plasma method

“…The efficiency of these catalysts were mentioned by Sanchez et al [20] for poly(vinyl alcohol) functionalization by monosuccinate groups. The experimental conditions of these two ways explained above are those used in the Hadamard experimental design described in Section 3.2 and shown in Table 1.…”