Poly(ε-caprolactone) (PCL) fibers incorporated with phase-changeable fatty acid and indocyanine green for NIR light-triggered, localized anti-cancer drug release

Park, Ju Hyang; Choi, Ji Hyun; Son, Jun‐Hyeok; Hwang, Se Jeong; Seo, Hojun; Kang, Inn‐Kyu; Park, Minwoo; Kim, Jong-Bok; Hyun, Dong Choon

doi:10.1016/j.polymer.2017.12.026

Cited by 15 publications

(16 citation statements)

References 32 publications

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“…Similarly, Ducray et al prepared ICG-encapsulated silica-PCL nanocomposites for laser tissue soldering, in which the exposure of ICG-encapsulated nanoparticles had significantly affected the mitochondrial function [ 125 ]. In another study, Park et al fabricated ICG sheath incorporated PCL fibers, which exhibited excellent NIR absorption efficiency, acceleration of the ICG release, and the substantial enhancement of the anticancer activity in conjunction with the hyperthermia effect [ 126 ]. On the other hand, ICG self-assembly into the PCL-lipid nanocomposites had significantly enriched the combinational therapy based on realizing a faster photothermal-induced release and effectively restraining the tumor growth or metastasis [ 127 ].…”

Section: Icg-encapsulated Polymeric Compositesmentioning

confidence: 99%

Leveraging Engineering of Indocyanine Green-Encapsulated Polymeric Nanocomposites for Biomedical Applications

et al. 2018

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In recent times, photo-induced therapeutics have attracted enormous interest from researchers due to such attractive properties as preferential localization, excellent tissue penetration, high therapeutic efficacy, and minimal invasiveness, among others. Numerous photosensitizers have been considered in combination with light to realize significant progress in therapeutics. Along this line, indocyanine green (ICG), a Food and Drug Administration (FDA)-approved near-infrared (NIR, >750 nm) fluorescent dye, has been utilized in various biomedical applications such as drug delivery, imaging, and diagnosis, due to its attractive physicochemical properties, high sensitivity, and better imaging view field. However, ICG still suffers from certain limitations for its utilization as a molecular imaging probe in vivo, such as concentration-dependent aggregation, poor in vitro aqueous stability and photodegradation due to various physicochemical attributes. To overcome these limitations, much research has been dedicated to engineering numerous multifunctional polymeric composites for potential biomedical applications. In this review, we aim to discuss ICG-encapsulated polymeric nanoconstructs, which are of particular interest in various biomedical applications. First, we emphasize some attractive properties of ICG (including physicochemical characteristics, optical properties, metabolic features, and other aspects) and some of its current limitations. Next, we aim to provide a comprehensive overview highlighting recent reports on various polymeric nanoparticles that carry ICG for light-induced therapeutics with a set of examples. Finally, we summarize with perspectives highlighting the significant outcome, and current challenges of these nanocomposites.

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Section: Icg-encapsulated Polymeric Compositesmentioning

confidence: 99%

Leveraging Engineering of Indocyanine Green-Encapsulated Polymeric Nanocomposites for Biomedical Applications

et al. 2018

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“…In order to provide the hollow NPs with a responsiveness to NIR light, we added them with ICG, which is a NIR light absorbing photothermal agent [21]. Its inclusion was accomplished through a series of processes involving the formation of a composite layer consisting of the FA mixture, PCL, and hydrophobic ICG-tetrabutylamine, the generation of corresponding composite rings, their conversion into hollow particles with openings on the shells, and the sealing of the openings.…”

Section: Resultsmentioning

confidence: 99%

“…After removing the supernatant, the sample was stored in vacuum for 24 h to completely remove residual water. The amounts of loaded ICG and DOX were checked by dissolving 10 mg of the NPs loaded with them in 2 mL of TFE, followed by analyzing 1 mL of the solution via ultraviolet–visible (UV-Vis) spectrophotometry (T60, PG Instrument, Leicestershire, UK), as previously reported [21]. The amount of loaded DOX was determined from the UV-Vis absorbance at 490 nm using a calibration curve constructed from a series of drug solutions in TFE.…”

Section: Methodsmentioning

confidence: 99%

“…At different time intervals, the suspension was centrifuged (12,000 rpm, 10 min), followed by taking out 1 mL of the colloid-free solution and then adding 1 mL of fresh buffer under mechanical agitation to re-suspend the NPs without any aggregation. The amount of released DOX was determined from the UV-Vis absorbance at 478 nm using a calibration curve constructed from a series of DOX solutions in PBS buffer, as previously reported [21]. The amount of released FITC-BSA was evaluated from a calibration curve of the fluorescence intensity for solutions with known concentrations of FITC-BSA obtained using a microplate reader (EL800, BIO-TEK, Winooski, VT, USA), as reported in previous literature [22].…”

Section: Methodsmentioning

confidence: 99%

“…The viabilities of SK-BR3 and NHDF cells against the hydrophobic ICG-tetrabutylamine and the NIR light irradiation were evaluated using the WST-1 assay, as previously reported [21]. Briefly, each type of the cells was seeded at a density of 20,000 cells/well in a 24-well cell culture plate for 24 h. In order to investigate the cytotoxicity of the hydrophobic ICG to the cells, the medium was replaced with 1 mL of fresh medium, followed by introducing a hydrophobic ICG solution (10 μL) in dimethyl sulfoxide with a certain concentration.…”

Section: Methodsmentioning

confidence: 99%

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Poly(ε-caprolactone) (PCL) Hollow Nanoparticles with Surface Sealability and On-Demand Pore Generability for Easy Loading and NIR Light-Triggered Release of Drug

et al. 2019

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A new system for the easy loading and NIR light-triggered release of drugs is introduced. It consists of poly(ε-caprolactone) (PCL) hollow nanoparticles with surface openings containing a biodegradable fatty acid with phase-change ability and a biocompatible photothermal agent. These openings, which can enhance the connectivity between the interior and the exterior, enable the easy loading of drug molecules into the interior voids, and their successive sealing ensures a stable encapsulation of the drug. Upon exposure to an external NIR light irradiation, the photothermal agent generates heat that raises the local temperature of the hollow particles above the melting point of the fatty acid, leading to the formation of nanopores on their shells, and consequently, the instant release of the encapsulated drug molecules through the pores. The synergistic activity of the hyperthermia effect from the photothermal agent and the NIR-triggered release of the drug molecules results in noticeable anticancer efficacy.

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Large‐Sized Hydrogel Sheet Incorporated with Dual Physical Crosslinkers for Enhanced Mechanical and Adhesive Properties

Nam,

Park,

Kim

et al. 2024

Adv Materials Inter

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This work reports the fabrication of a large‐sized hydrogel sheet with enhanced mechanical and adhesive properties. The fabrication involves the introduction of carboxymethyl‐modified cellulose nanofibers (m‐CNFs) and solid silica nanoparticles (SSNs) as physical cross‐linkers into acrylic acid monomer (AA), followed by bar coating and photopolymerization. The addition of the nanomaterials to the monomer solution renders it viscous, enabling the fabrication of A4‐sized hydrogel sheets with uniform thickness and enhanced mechanical and adhesive properties. Interestingly, the combined incorporation of both the nanomaterials generates a synergistic effect to improve the properties much more, which results from the hierarchical rupture of the multiple hydrogen‐bonded interactions among the poly(acrylic acid) (PAA) matrix, m‐CNFs, and SSNs. Under optimal conditions, the hydrogel sheet incorporated with the dual crosslinkers exhibits a sevenfold higher toughness and a sixfold increased peel strength than plain PAA, together with good biocompatibility. Furthermore, when mesoporous silica nanoparticles (MSNs) with active agent loading into their pores are incorporated instead of SSNs, the active agent can be released from the hydrogel sheet in a sustained or temperature‐sensitive manner, indicating that the system is potentially applicable to transdermal drug delivery system with no additional adhesive.

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Poly(ε-caprolactone) (PCL) fibers incorporated with phase-changeable fatty acid and indocyanine green for NIR light-triggered, localized anti-cancer drug release

Cited by 15 publications

References 32 publications

Leveraging Engineering of Indocyanine Green-Encapsulated Polymeric Nanocomposites for Biomedical Applications

Leveraging Engineering of Indocyanine Green-Encapsulated Polymeric Nanocomposites for Biomedical Applications

Poly(ε-caprolactone) (PCL) Hollow Nanoparticles with Surface Sealability and On-Demand Pore Generability for Easy Loading and NIR Light-Triggered Release of Drug

Large‐Sized Hydrogel Sheet Incorporated with Dual Physical Crosslinkers for Enhanced Mechanical and Adhesive Properties

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